II.4 ライフシステム部門

現代の科学技術の進歩において，物質，生命に関する基礎理論とその応用技術の進歩が果たす役割は大きい．ライフシステム部門は，こうした物質，生命に関する研究分野を担っており，化学応用工学分野の物質変換化学，物質機能化学の2大講座および生物工学分野の生命システム工学，生命情報工学，生命機能工学の3大講座の計5大講座からなる． 化学応用工学分野の物質変換化学大講座では，物質合成の基礎となる合成法の開発・構造解析・反応機構解明とそれらを応用した高付加価値物質・高機能材料の合成とその手法に関する研究を行っている．有機合成・高分子合成・材料合成の3研究グループで機能性有機分子および生理活性分子の合成と反応機構，新しい重合反応の開発と重合機構，高機能性材料の開発とその物性などを研究している．他方，物質機能化学大講座では，分析化学，物理化学，電気化学などの手法を用いて「もの」の性質とその本質をより深く研究し，それを新しい技術に活かす教育・研究を実施している．新規化学センサーやバイオセンサーの開発，層状化合物の合成，環境中の微量元素の分析，高圧力下の生物化学反応，超臨界流体の化学，タンパクの結晶成長，原子レベルの電極設計など多様な最先端研究テーマに取り組んでいる．これらが相互に協力して物質の分子設計から機能設計にわたって，化学の諸分野の教育・研究を行い，産業界の要請に応えうる人材養成をめざしている． 生物工学分野では，近年目覚ましい分子生物学等のライフサイエンス技術の進歩を踏まえ，生命現象を織りなす生物の様々な機能の発現機構を分子レベルで明らかにして，その生物機能に学んでそれを超える技術の開発を行っている．例えば，生物学研究の中で開発・発展してきた遺伝子組換え，細胞培養，酵素固定化，バイオインフォマティクス，タンパク質加工等の手法を工学に取り入れ，有用物質や医薬品の生産，エネルギー産生，環境保全，情報処理等の工学的利用を目指している．これらの取り組みは，現在人類が直面しているエネルギー，環境，医療，食糧，情報等に関連する様々な問題解決に資するものである．このような生命現象の分子レベルでの解明を進める基礎的研究とそれに根ざした新規のバイオテクノロジーの開発研究を推進するため，生命機能工学，生命情報工学，生命システム工学の3大講座が協力し合い，社会の要請に応え得る有能な人材の育成を行っている．

II.4.1 物質変換化学

当大講座では，反応中間体および炭素豊富化合物の構造と反応性，新規立体選択的反応開発と生理活性物質合成への応用，ラジカル重合・縮合反応による精密高分子合成，環境に調和した有機合成手法の開発, レオロジー機能材料開発等に関する研究を実施している．

II.4.1.1 教員組織

(1) 氏名，(2) メールアドレス，(3) 職名・学位，(4) 専門分野，(5) 所属学会（役職名），(6) 社会活動（役職名），(7) 主要研究テーマ，(8) キーワード，(9) 共同研究可能テーマ

(1) 河村 保彦, Yasuhiko Kawamura, (2) kāwāmūŗā (@) ċhėm ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 教授・理学博士, (4) 有機化学, (5) 社団法人 有機合成化学協会 (中国四国支部幹事)・アメリカ化学会・光化学協会・日本コンピュータ化学会・第24回有機合成化学セミナー・若手研究者のためのセミナー 第24回若手化学者のための化学道場(徳島2008)・2011年日本化学会西日本大会・中国四国化学と工業懇話会・技術者教育に関する分野別の到達目標に関する調査研究 (化学バイオ分野委員)・社団法人 有機合成化学協会 (評議員)・社団法人 日本化学会・2012年度第3回(第10回)プロセス化学東四国フォーラムセミナー・第30回有機合成セミナー (実行委員), (6) 社団法人 有機合成化学協会 (中国四国支部幹事, 評議員)・文部科学省科学技術政策研究所 科学技術動向研究センター (専門調査員)・徳島大学テクノクラスター (班員)・徳島大学工業会 (理事)・徳島大学生活協同組合 (理事)・社団法人 日本化学会 (支部幹事)・大学院ソシオテクノサイエンス研究部 (専門調査員)・阿南工業高等専門学校 (寄附講座評価委員会委員長)・阿南工業高等専門学校 (参与)・火力原子力発電技術協会 四国支部 (参与)・四国生産性本部理事 (理事)・徳島市中小企業振興対策委員会 (委員)・徳島ニュービジネス協議会 (理事)・財団法人 阿波銀行学術·文化振興財団 (評議員), (7) 複素小員環イオンラジカルの構造と反応性に関する研究, 新規有機光化学反応の開発, 芳香族化合物の合成と反応, (8) イオンラジカル, 複素環化合物, 光化学反応, 反応性中間体, フラーレン, (9) 光と物質との相互作用に関する研究, 複素環化合物の合成に関する研究, 反応中間体に関する研究

(1) 右手 浩一, Koichi Ute, (2) ūtė (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 教授・工学博士, (4) 高分子特性解析, 高分子合成化学, 高分子の構造と基礎物性, (5) 社団法人 高分子学会 (中国四国支部幹事, 代議員, 「高分子」編集委員会支部委員)・社団法人 日本化学会 (中国四国支部幹事, 代表正会員)・社団法人 日本分析化学会 高分子分析研究懇談会・社団法人 日本接着学会 (評議員)・社団法人 有機合成化学協会・社団法人 近畿化学協会・アメリカ化学会・International Journal of Polymer Analysis and Characterization (Editorial Board), (6) 独立行政法人 産業技術総合研究所 超臨界流体研究センター・独立行政法人日本学術振興会 (特別研究員等審査会専門委員および国際事業委員会書面審査員)・独立行政法人 新エネルギー·産業技術総合開発機構 (テーマ公募型事業ピアレビュア)・大学連携研究設備ネットワーク(旧・化学系設備有効活用ネットワーク) (協議会委員), (7) 核磁気共鳴分光法(NMR)とクロマトグラフィーによる高分子キャラクタリゼーション, ビニルモノマーの共重合における組成・連鎖分布の規制, 均一ポリマーの合成および分離精製と構造化学, (8) パルス磁場勾配NMR, LC-NMR, 臨界吸着クロマトグラフィー, 精密重合, 高分子材料設計, 超臨界流体クロマトグラフィー, 単結晶X線結晶構造解析, 質量分析, 熱分析, (9) (@.collaborate)

(1) 今田 泰嗣, Yasushi Imada, (2) īmāđā (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 教授・博士(工学), (4) 有機合成化学, 有機金属化学, (5) 公益社団法人 有機合成化学協会・一般社団法人 近畿化学協会 (会誌編集委員会 委員, 会誌編集委員会 委員長, 代議員, 有機金属部会幹事)・公益社団法人 日本化学会 (中国四国支部 副支部長, 中国四国支部 支部長)・アメリカ化学会・公益社団法人 高分子学会, (6) , (7) 有機分子触媒による酸化反応, 遷移金属錯体触媒による効率的分子変換反応, (8) 有機分子触媒, 酸化, 環境調和型分子変換, 触媒的分子変換, 遷移金属錯体触媒, 立体選択的反応, (9) 有機分子触媒による環境調和型物質変換反応の開発, 遷移金属錯体触媒による高効率分子変換反応の開発

(1) 南川 慶二, Keiji Minagawa, (2) mīņāġāwā (@) ċhėm ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 准教授・博士(理学), (4) 有機材料化学, (5) 社団法人 高分子学会・日本レオロジー学会 (エレクトロレオロジー研究会幹事)・社団法人 日本化学会・プラスチック成形加工学会・日本エネルギー環境教育学会, (6) 徳島県 徳島県教育委員会 (徳島科学技術高等学校SSH運営指導委員会委員), (7) エレクトロレオロジー流体材料の合成, 溶液内高分子の構造変化と分子運動の解析, 超音波重合, (8) 高分子材料, ER流体, エレクトロレオロジー, ソノケミストリ, (9) レオロジー可変材料の合成と物性評価

(1) 平野 朋広, Tomohiro Hirano, (2) hīŗāņō (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 准教授・博士(理学), (4) 高分子合成化学, (5) 社団法人 高分子学会 (中国四国支部若手研究会運営委員, NMR研究会運営委員)・社団法人 日本化学会・アメリカ化学会・高分子分析研究懇談会, (6) , (7) ラジカルおよびアニオン重合による立体規則性ポリマーの合成およびキャラクタリゼーション, (8) アニオン重合, ラジカル重合, 立体規則性ポリマー, (9) 高分子合成, NMRによるキャラクタリゼーション

(1) 西内 優騎, Masaki Nishiuchi, (2) ņīśhīūċh (@) ċhėm ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 講師・博士(工学), (4) 有機化学, (5) 社団法人 日本化学会・社団法人 有機合成化学協会, (6) , (7) 立体選択的複素環化合物の合成研究, (8) 双極性環状付加反応, (9) (@.collaborate)

(1) 押村 美幸, Miyuki Oshimura, (2) ōśhīmūŗā (@) ċhėm ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 助教・博士, (4) 高分子合成化学, (5) 社団法人 高分子学会, (6) 高分子分析研究懇談会 (運営委員), (7) 開環重合によるポスエステル合成, (8) 開環重合, 脂肪族ポリエステル, (9) (@.collaborate)

(1) 荒川 幸弘, Yukihiro Arakawa, (2) āŗākāwā ₍.₎ yūkīhīŗō (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 助教・博士(工学), (4) 有機合成化学, (5) 社団法人 日本化学会・アメリカ化学会・社団法人 高分子学会, (6) , (7) 有機分子触媒による不斉分子変換法, 高分子固定化触媒による環境調和型有機合成, (8) 有機分子触媒, 不斉反応, 環境調和型分子変換, 固定化触媒, (9) 有機分子触媒による環境調和型物質変換反応の開発

(1) 八木下 史敏, Fumitoshi Yagishita, (2) yāġīśhītāf (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 助教・博士(工学), (4) 有機化学, (5) 社団法人 日本化学会・有機結晶部会・光化学協会, (6) , (7) (@.theme), (8) (@.keyword), (9) (@.collaborate)

II.4.1.2 研究業績

【著　　書】

1. 右手 浩一 : 大谷肇・寶崎達也編「合成高分子クロマトグラフィー」, --- 3-2-9節「LC/NMR，SEC/NMR」 ---, 株式会社 オーム社, 東京, 2013年7月.

2. Tomohiro Hirano and Takehiro Kitaura : Stereospecific polymerization, In "Encyclopedia of Polymeric Nanomaterials", Springer-Verlag, Heidelberg, July 2015.

【学術論文】

1. Ishiuchi Kan'ichiro, Nakazawa Takehito, Fumitoshi Yagishita, Mino Takashi, Noguchi Hiroshi, Hotta Kinya and Watanabe Kenji : Combinatorial Generation of Complexity by Redox Enzymes in the Chaetoglobosin A Biosynthesis, Journal of the American Chemical Society, Vol.135, No.19, pp.7371-7377, 2013.

2. Fumitoshi Kaneko, Aurel Radulescu and Koichi Ute : Time-resolved SANS studies on guest exchange processes in co-crystals of syndiotactic polystyrene, Polymer, Vol.54, No.13, pp.3145-3149, 2013.

3. Yasushi Imada, Itoko Tonomura, Naruyoshi Komiya and Takeshi Naota : Aerobic Oxidation of Sulfides with Vitamin B2-derived Organocatalyst, Synlett, Vol.24, No.13, pp.1679-1682, 2013.

4. Yasushi Imada, Masamitsu Takagishi, Naruyoshi Komiya and Takeshi Naota : Oxidation of Sulfides with Hydrogen Peroxide Catalyzed by Vitamin B2 Derivatives, Synthetic Communications, Vol.43, No.22, pp.3064-3071, 2013.

5. Fumitoshi Yagishita, Okamoto Kazuma, Kamataki Norifumi, Kanno Shota, Mino Takashi, Kasashima Yoshio and Sakamoto Masami : Chiral Symmetry Breaking of Axially Chiral Nicotinamide by Crystallization from the Melt, Chemistry Letters, Vol.42, No.12, pp.1508-1510, 2013.

6. Tomohiro Hirano, Akiko Ono, Hiroaki Yamamoto, Takeshi Mori, Yasushi Maeda, Miyuki Oshimura and Koichi Ute : Effect of composition and stereoregularity on phase-transition behavior of aqueous N-ethylacrylamide/N-n-propylacrylamide copolymer solutions, Polymer, Vol.54, No.21, pp.5601-5608, 2013.

7. Yasushi Imada, Yudai Kugimiya, Shotaro Iwata, Naruyoshi Komiya and Takeshi Naota : Non-Covalently Dendronized Flavins as Organocatalysts for Aerobic Reduction of Olefins, Tetrahedron, Vol.69, No.40, pp.8572-8578, 2013.

8. Yusuke Murata, Masaki Takahashi, Fumitoshi Yagishita, Masami Sakamoto, Tetsuya Sengoku and Hidemi Yoda : Construction of Spiro-Fused 2-Oxindole/α-Methylene- γ-Butyrolactone Systems with Extremely High Enantioselectivity via Indium-Catalyzed Amide Allylation of N-Methyl Isatin, Organic Letters, Vol.15, No.24, pp.6182-6185, 2013.

9. Fumitoshi Yagishita, Kamataki Norifumi, Okamoto Kazuma, Kanno Shota, Mino Takashi, Masu Hyuma and Sakamoto Masami : Deracemization of Axially Chiral Nicotinamides by Dynamic Salt Formation with Enantiopure Dibenzoyltartaric Acid (DBTA), Molecules, Vol.18, No.11, pp.14430-14447, 2013.

10. Mohamed Reda Berber, Inas Hazzaa Hafez, Keiji Minagawa and Takeshi Mori : A sustained controlled release formulation of soil nitrogen based on nitrate-layered double hydroxide nanoparticle material, Journal of Soils and Sediments, Vol.14, No.1, pp.60-66, 2014.

11. Yasushi Imada, Takahiro Kitagawa, Shotaro Iwata, Naruyoshi Komiya and Takeshi Naota : Oxidation of sulfides with hydrogen peroxide catalyzed by synthetic flavin adducts with dendritic bis(acylamino)pyridines, Tetrahedron, Vol.70, No.2, pp.495-501, 2014.

12. Fumitoshi Kaneko, Radulescu Aurel and Koichi Ute : Time-resolved small-angle neutron scattering study on guest-exchange processes in co-crystals of syndiotactic polystyrene, Journal of Applied Crystallography, Vol.47, pp.6-13, 2014.

13. 曽我部 啓介, 右手 浩一 : 誘導体化ポリ乳酸の末端基及び鎖延長したポリ乳酸の接合部位のDOSYによる分析, 分析化学, Vol.63, No.2, 93-99頁, 2014年.

14. Takayoshi Saruwatari, Fumitoshi Yagishita, Takashi Mino, Hiroshi Noguchi, Kinya Hotta and Kenji Watanabe : Cytochrome P450 as Dimerization Catalyst in Diketopiperazine Alkaloid Biosynthesis, ChemBioChem, Vol.15, No.5, pp.656-659, 2014.

15. Shoko Ueta, Kazuo Hida, Masaki Nishiuchi and Yasuhiko Kawamura : Regioisomeric Allene Dimer Formation by the Reaction of Tetraarylbutatrienes with Tetracyanoethene, Organic & Biomolecular Chemistry, Vol.12, No.17, pp.2784-2791, 2014.

16. Yukihiro Arakawa, P Sven Fritz and Helma Wennemers : Organocatalytic stereoselective synthesis of acyclic -nitrothioesters with all-carbon quaternary stereogenic centers., The Journal of Organic Chemistry, Vol.79, No.9, pp.3937-3945, 2014.

17. Taichi Abe, Takashi Mino, Kohei Watanabe, Fumitoshi Yagishita and Masami Sakamoto : Suzuki Miyaura Coupling of Aryl Sulfonates with Arylboronic Acids Using a Morpholine Pd(OAc)₂ Catalyst System, European Journal of Organic Chemistry, Vol.2014, No.18, pp.3909-3916, 2014.

18. 今田 泰嗣 : フラビン触媒を用いた酸素酸化システムの開発, 化学と工業, Vol.67, No.6, 480-482頁, 2014年.

19. Tetsuya Sengoku, Kosuke Suzuki, Ken Nakayama, Fumitoshi Yagishita, Masami Sakamoto, Masaki Takahashi and Hidemi Yoda : Novel chiral tetramic acid-derived diols: organocatalytic facile synthesis and unique structural properties, RSC Advances, Vol.4, No.58, pp.30775-30779, 2014.

20. Masaki Takahashi, Yusuke Murata, Fumitoshi Yagishita, Masami Sakamoto, Tetsuya Sengoku and Hidemi Yoda : Catalytic Enantioselective Amide Allylation of Isatins and Its Application in the Synthesis of 2-Oxindole Derivatives Spiro-Fused to the α-Methylene-γ-Butyrolactone Functionality, Chemistry - A European Journal, Vol.20, No.35, pp.11091-11100, 2014.

21. Masaki Takahashi, Yusuke Murata, Masahiro Ishida, Fumitoshi Yagishita, Masami Sakamoto, Tetsuya Sengoku and Hidemi Yoda : Catalytic amide allylation of α-ketoesters: extremely high enantioselective synthesis of ester functionalised α-methylene-γ-butyrolactones, Organic & Biomolecular Chemistry, Vol.12, No.39, pp.7686-7689, 2014.

22. Yasushi Imada, Chiaki Okita, Hiroki Maeda, Masayuki Kishimoto, Yoshinori Sugano, Hiroyuki Kaneshiro, Yuri Nishida, Soichiro Kawamorita, Naruyoshi Komiya and Takeshi Naota : Ring-expanding Metathesis Oligomerization of Cyclic Nitrones, European Journal of Organic Chemistry, Vol.2014, No.26, pp.5670-5674, 2014.

23. Fumitoshi Yagishita, Naoya Takagishi, Hiroki Ishikawa, Yoshio Kasashima, Takashi Mino and Masami Sakamoto : Deracemization of Quinolonecarboxamides by Dynamic Crystalline Salt Formation and Asymmetric Photoreaction by Using the Frozen Chirality, European Journal of Organic Chemistry, Vol.2014, No.29, pp.6366-6370, 2014.

24. Tomohiro Hirano, Yuya Miyamoto, Shinya Amano, Kazuya Tatsumi, Takuya Anmoto, Hiroshi Kimura, Ken Yoshida, Miyuki Oshimura and Koichi Ute : Hydrogen-bond-assisted isotactic-specific radical polymerization of N-vinyl-2-pyrrolidone with tartrate additives in toluene at low temperatures: high-resolution 1H NMR analysis, RSC Advances, Vol.4, No.95, pp.53079-53089, 2014.

25. Fumitoshi Yagishita, Nozomi Baba, Yuki Ueda, Satoshi Katabira, Yoshio Kasashima, Takashi Mino and Masami Sakamoto : Diastereoselective Photodimerization Reactions of Chromone-2- carboxamides to Construct a C2-Chiral Scaffold, Organic & Biomolecular Chemistry, Vol.12, No.47, pp.9644-9649, 2014.

26. Miyuki Oshimura, Ryo Okazaki, Tomohiro Hirano and Koichi Ute : Ring-opening polymerization of epsilon-caprolactone with dilithium tetra-tert-butylzincate under mild conditions, Polymer Journal, Vol.46, No.12, pp.866-872, 2014.

27. Kim Youngwoong, Tokuda Takuya, Fumitoshi Yagishita, Masu Hyuma, Kubo Minako, Murashiro Katsuyuki and Hoshino Katsuyoshi : Preparation and Characterization of Oligo(9,9'-di-p-tolyl-3,3'-bicarbazyl) and Its Application to Transparent Conducting Materials, Chemistry Letters, Vol.43, No.1, pp.89-91, 2014.

28. Yasuike Nobuo, Fumitoshi Yagishita, Sunaoshi Kazushi, Hasegawa Yasuhiro, Mino Takashi and Sakamoto Masami : Reversible changes of axial chirality of naphthamide by photochemical and thermal reactions, Journal of Photochemistry and Photobiology A: Chemistry, 2015.

29. Yasushi Imada, Motonari Osaki, Mikiko Noguchi, Takatoshi Maeda, Misa Fujiki, Soichiro Kawamorita, Naruyoshi Komiya and Takeshi Naota : Flavin-Functionalized Gold Nanoparticles as an Efficient Catalyst for Aerobic Organic Transformations, ChemCatChem, Vol.7, No.1, pp.99-106, 2015.

30. Tomohiro Hirano, Tatsuya Saito, Yoshitaka Kurano, Yohei Miwa, Miyuki Oshimura and Koichi Ute : Dual role for alkali metal cations in enhancing the low-temperature radical polymerization of N,N-dimethylacrylamide, Polymer Chemistry, Vol.6, No.11, pp.2054-2064, 2015.

31. Fumitoshi Kaneko, Naoki Seto, Shuma Sato, Aurel Radulescu, Maria Maddalena Schiavone, Jürgen Allgaier and Koichi Ute : Development of a Simultaneous SANS/FTIR Measuring System, Chemistry Letters, Vol.44, No.4, pp.497-499, 2015.

32. Keiji Minagawa, Genki Shiizaki, Yukihiro Arakawa, Yasushi Imada and Masami Tanaka : Controlled Physical Gelation of Thermoresponsive Poly(2-propionamidoacrylic acid) Aqueous Solution, Advanced Materials Research, Vol.1110, pp.96-99, 2015.

33. Haruka Suzuki, Ryo Inoue, Soichiro Kawamorita, Naruyoshi Komiya, Yasushi Imada and Takeshi Naota : Highly Fluorescent Flavins: Rational Molecular Design for Quenching Protection Based on Repulsive and Attractive Control of Molecular Alignment, Chemistry - A European Journal, Vol.21, No.25, pp.9171-9178, 2015.

34. Tomohiro Hirano, Tadashi Segata, Junpei Hashimoto, Yohei Miwa, Miyuki Oshimura and Koichi Ute : Syndiotactic- and heterotactic-specific radical polymerization of N-n-propylmethacrylamide complexed with alkali metal ions, Polymer Chemistry, Vol.6, No.27, pp.4927-4939, 2015.

35. Hiroki Iida, Shun-Ichi Murahashi and Yasushi Imada : Biomimetic flavin-catalysed reactions for organic synthesis, Organic & Biomolecular Chemistry, Vol.13, No.28, pp.7599-7613, 2015.

36. Yuki Ueda, Fumitoshi Yagishita, Hiroki Ishikawa, Yuki Kaji, Nozomi Baba, Yoshio Kasashima, Takashi Mino and Masami Sakamoto : A new class of C2 chiral photodimer ligands for catalytic enantioselective diethylzinc addition to arylaldehydes, Tetrahedron, Vol.71, No.36, pp.6254-6258, 2015.

37. Masami Tanaka, Keiji Minagawa, Yukihiro Arakawa and Yasushi Imada : Analysis of Interaction between Diphenhydramine and Human Serum Albumin, IMPACT : International Journal of Research in Applied, Natural and Social Sciences, Vol.3, No.10, pp.81-88, 2015.

38. Keiji Minagawa, Mikito Yasuzawa, Yukihiro Arakawa, Yasushi Imada and Shingo Fujita : Design of Effective Chemistry Laboratory Class Based on Partnership among High School, University and Graduate School, IMPACT : International Journal of Research in Applied, Natural and Social Sciences, Vol.3, No.10, pp.121-124, 2015.

39. Sato Michio, Fumitoshi Yagishita, Mino Takashi, Uchiyama Nahoko, Patel Ashay, Chooi Yit-Heng, Goda Yukihiro, Xu Wei, Noguchi Hiroshi, Yamamoto Tsuyoshi, Hotta Kinya, Houk N. Kendall, Tang Yi and Watanabe Kenji : Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition, ChemBioChem, Vol.16, No.16, pp.2294-2298, 2015.

40. Huijun Liu, Shoko Ueta, Fumitoshi Yagishita, Masaki Nishiuchi and Yasuhiko Kawamura : One-pot synthesis of novel polysubstituted 1,1-phenylene-bipyrrole via the double [3+2] cycloaddition reaction, Tetrahedron, Vol.71, No.22, pp.3614-3618, 2015.

41. Takashi Mino, Minato Asakawa, Yamato Shima, Haruka Yamada, Fumitoshi Yagishita and Masami Sakamoto : Chiral N-(tert-butyl)-N-methylaniline type ligands: synthesis and application to palladium-catalyzed asymmetric allylic alkylation, Tetrahedron, Vol.71, No.35, pp.5985-5993, 2015.

42. Miyuki Oshimura, Yuki Oda, Keita Kondoh, Tomohiro Hirano and Koichi Ute : Efficient acylation and transesterification catalyzed by dilithium tetra-tert-butylzincate at low temperatures, Tetrahedron Letters, Vol.57, No.19, pp.2070-2073, 2016.

【総説・解説】

1. 平野 朋広 : 合成高分子のNMRスペクトルの多変量解析-オフライン二次元NMR法-, ぶんせき, Vol.2013, No.10, 631-632頁, 2013年10月.

2. 今田 泰嗣 : フラビン分子を有機フォトレドックス触媒とする分子変換反応の開発, 文部科学省科学研究費補助金「新学術研究領域」(平成23-27年度)有機分子触媒による未来型分子変換 News Letter, No.33, 1頁, 2014年9月.

3. 今田 泰嗣 : 中国四国支部の活動, 化学と工業, Vol.68, No.5, 458頁, 2015年5月.

4. 平野 朋広 : 水素結合を利用したN-アルキルアクリルアミドの立体特異性ラジカル重合, 高分子論文集, Vol.72, No.5, 218-231頁, 2015年5月.

【国際会議 Proceedings】

1. Yukihiro Arakawa and Helma Wennemers : Organocatalytic Stereoselective Synthesis of Acyclic Thioesters with an All-Carbon Quaternary Stereogenic Center, 4th UK/Japan Conference in Catalytic Asymmetric Synthesis, Sendai International Center, April 2013.

2. Fumiaki Sato, Yukihiro Arakawa, Keiji Minagawa and Yasushi Imada : Flavin Catalysts Captured in Network Polymers, Advanced Molecular Transformations by Organocatalysts 1st International Conference & 6th Symposium on Organocatalysis, Otsu, May 2013.

3. Shoko Ueta, Yasuhiko Kawamura, Tetsuya Kozai, Hirokazu Hashizume and Masaki Nishiuchi : Reactions of Tetraaryl[2-5]cumulenes: Cyclooligomerizations, Cycloadditions, and Charge-Transfer Reactions with Tetracyanoethene, 11th International Symposium on Functional pi-Electron Systems (Fpi-11), Arcachon, France, June 2013.

4. Shoko Ueta, Hirokazu Hashizume, Masaki Nishiuchi and Yasuhiko Kawamura : Regioisomeric Allene Dimer Formation by the Reaction of Tetraarylbutatriene with Tetracyanoethene, 15th International Symposium on Novel Aromatic Compounds, Taipei, Taiwan, July 2013.

5. Shinji Nishimae, Yoshihumi Isobe, Tomoki Yabutani, Toshio Takayanagi, Tomohiro Hirano and Koichi Ute : Poyion Complxes Formed between Hyper-branched Polyelectrolytes Synthesized by Ininiator-Fragment Incorporation Radical Polymerization Method, ASIANALYSIS XII The Twelfth Asian Conference on Analytical Sciences, Fukuoka, Aug. 2013.

6. Risa Yahata, Koto Suganuma, Tetsuo Asakura, Miyuki Oshimura, Tomohiro Hirano and Koichi Ute : Tacticity analysis of poly(lactic acid) by multivariate analysis of NMR spectra, IUPAC International Symposium on Ionic Polymerization 2013 (IP2013), Awaji, Sep. 2013.

7. Tomohiro Hirano, Tadashi Segata, Miyuki Oshimura and Koichi Ute : Radical polymerization of N-alkylmethacrylamides in the presence of alkali metal salts: acceleration and stereocontrol, IUPAC International Symposium on Ionic Polymerization 2013 (IP2013), Awaji, Sep. 2013.

8. Yu-Chin Hsu, Koji Funaoka, Manato Harada, Tomohiro Hirano and Koichi Ute : Multivariate analysis of C-13 NMR spectra of methacrylate copolymers prepared by copolymerization or polymer reactions, IUPAC International Symposium on Ionic Polymerization 2013 (IP2013), Awaji, Sep. 2013.

9. Miyuki Oshimura, Ryo Okazaki, Yuji Tanaka, Tomohiro Hirano and Koichi Ute : Ring-Opening Polymerization of Cyclic Esters with Lithium tert-Butylzincate under Mild Conditions, IUPAC International Symposium on Ionic Polymerization 2013 (IP2013), Awaji, Sep. 2013.

10. Yu-Chin Hsu, Koichi Ute and Chen-Chien Wang : Multivariate Analysis of Monomer Sequence of Copolymer Obtained by Partial Hydrolysis of Poly(tert-butyl methacrylate), 2013 International Symposium on Nano Science and Technology, Tainan, Nov. 2013.

11. Koichi Ute : Monomer Sequence Distribution of Methacrylate Copolymers Prepared by Copolymerization or Polymer Reactions as Studied by Multivariate Analysis of C-13 NMR Spectra, 2013 International Symposium on Nano Science and Technology, Tainan, Nov. 2013.

12. Tadashi Segata, Miyuki Oshimura, Tomohiro Hirano and Koichi Ute : Stereospecific Radical Polymerizations of N-Alkylmethacrylamides in the Presence of Alkali Metal Salts and Phase Transition Behaviors of Aqueous Solutions of the Polymers Obtained, The 13th Pacific Polymer Conference (PPC 13), Kaohsiung, Nov. 2013.

13. Miyuki Oshimura, Takahiro Hiura, Akinori Saito, Makoto Fukuoka, Yusuke Hemmi, Hikaru Momose, Tomohiro Hirano and Koichi Ute : Direct Polycondensation of Mandelic Acid Using Onium Salt Catalysts, The 13th Pacific Polymer Conference (PPC 13), Kaohsiung, Nov. 2013.

14. Tomohiro Hirano, Risa Yahata, Koto Suganuma, Tetsuo Asakura, Miyuki Oshimura and Koichi Ute : Multivariate Analysis of NMR Spectra of Poly(Lactic Acid), The 13th Pacific Polymer Conference (PPC 13), Kaohsiung, Nov. 2013.

15. Yuki Konishi, Miyuki Oshimura, Tomohiro Hirano and Koichi Ute : Sugar Modification of Polyhydroxyurethanes Synthesized by Polyaddition of Five-Membered Cyclic Dicarbonates and Diamines, The 13th Pacific Polymer Conference (PPC 13), Kaohsiung, Nov. 2013.

16. Ryo Okazaki, Yuki Oda, Miyuki Oshimura, Tomohiro Hirano and Koichi Ute : Ring-Opening Polymerization of Cyclic Esters with Lithium t-Butylzincate in the Presence of Methacrylates, The 13th Pacific Polymer Conference (PPC 13), Kaohsiung, Nov. 2013.

17. Keigo Motoyama, Hiroyuki Kitayama, Yoshihiko Ikeda, Miyuki Oshimura and Koichi Ute : Structural Determination of Novel Polyamine by Correlation Analysis of 1H NMR and Nano Assisted Laser Desorption Ionization Mass Spectra, The 13th Pacific Polymer Conference (PPC 13), Kaohsiung, Nov. 2013.

18. Yoshitaka Kurano, Tatsuya Saito, Miyuki Oshimura, Tomohiro Hirano and Koichi Ute : Effect of Alkali Metal Salts on Radical Polymerization of Acrylic Monomers, The 13th Pacific Polymer Conference (PPC 13), Kaohsiung, Nov. 2013.

19. Koichi Ute : Monomer Sequence Analysis of Methacrylate Copolymers Prepared by Copolymerization or Polymer Reactions, The 13th Pacific Polymer Conference (PPC 13), Kaohsiung, Nov. 2013.

20. Fumitoshi Yagishita, Takagishi Naoya, Mino Takashi, Masu Hyuma and Sakamoto Masami : Asymmetric Reaction Using Frozen Chirality Derived from Chiral Crystals Generated by Dynamic Deracemization, The 21st International Conference on the Chemistry of the Organic Solid State, Oxford (UK), (month)2013.

21. Keiji Minagawa, Genki Shiizaki, Yukihiro Arakawa, Yasushi Imada and Masami Tanaka : Controlled Physical Gelation of Thermoresponsive Poly(2-propionamidoacrylic acid) Aqueous Solution, 7th International Conference on Advanced Materials Development and Performance, Busan, July 2014.

22. Masami Tanaka, Keiji Minagawa, Yukihiro Arakawa and Yasushi Imada : Interaction between Drugs and Biomedical Materials. II. Binding Position of Diphenhydramine to Human Serum Albumin, 7th International Conference on Advanced Materials Development and Performance, Busan, July 2014.

23. Liu Huijun, Fumitoshi Yagishita, Masaki Nishiuchi and Yasuhiko Kawamura : Synthesis of the Novel Polysubstituted N,N'-Phenylene-bis(pyrrole-3,4-dicarboxylates) via the Double 1,3-Dipolar Cycloaddition Reactiond, 14th International Symposium on Advancing the Chemical Sciences, Vol.Vol. 14, (号), p.143, Shanghai, Aug. 2014.

24. Keiji Minagawa, Mikito Yasuzawa, Yukihiro Arakawa, Yasushi Imada and Shingo Fujita : Attractive Materials for Engineering Chemistry Education Performed under High School/University/Graduate School Partnership, Proceedings of Asian Conference on Engineering Education 2014 (ACEE2014), Kumamoto, Oct. 2014.

25. Yasushi Imada : Organocatalytic Oxidations Catalyzed by Non-covalently Dendronized Flavins, Advanved Molecular Transformations by Organocatalysts 2nd International Conference and 7th Symposium on Organocatalysis, (都市), Nov. 2014.

26. Yoshitaka Kurano, Yohei Miwa, Miyuki Oshimura, Tomohiro Hirano and Koichi Ute : Study of radical polymerization mechanism of acrylamide derivatives in the presence of Li salts, The 10th International Polymer Conference (IPC2014), Tsukuba, Dec. 2014.

27. Mingyeh Chuang, Yuchin Hsu, Chihlung Chiu, Kouji Funaoka, Tomohiro Hirano and Koichi Ute : Analysis of monomer sequence of copolymers obtained by polymer reactions of isotactic and syndiotactic poly(benzyl methacrylate)s, The 10th International Polymer Conference (IPC2014), Tsukuba, Dec. 2014.

28. Tomohiro Hirano, Yuya Miyamoto, Shinya Amano, Kazuya Tatsumi, Miyuki Oshimura and Koichi Ute : Isotactic-specific radical polymerization of N-vinyl-2-pyrrolidone, The 10th International Polymer Conference (IPC2014), Tsukuba, Dec. 2014.

29. Chihlung Chiu, Manato Harada, Tomohiro Hirano and Koichi Ute : Analysis of monomer sequence of copolymers obtained by partial hydrolysis of poly(benzyl methacrylate), The 10th International Polymer Conference (IPC2014), Tsukuba, Dec. 2014.

30. Junpei Hashimoto, Tadashi Segata, Miyuki Oshimura, Tomohiro Hirano and Koichi Ute : Stereospecific radical polymerization of methacrylamide derivatives, The 10th International Polymer Conference (IPC2014), Tsukuba, Dec. 2014.

31. Yuki Oda, Ryo Okazaki, Miyuki Oshimura, Tomohiro Hirano and Koichi Ute : Functionalization of polyesters by transesterification in the presence of dilithium tetra-tert-butylzincate, The 10th International Polymer Conference (IPC2014), Tsukuba, Dec. 2014.

32. Takahiro Hiura, Miyuki Oshimura, Akinori Saito, Makoto Fukuoka, Yusuke Hemmi, Hikaru Momose, Tomohiro Hirano and Koichi Ute : Synthesis of optically-activite poly(mandelic acid)s obtained by direct polycondensation using onium salt catalysts, The 10th International Polymer Conference (IPC2014), Tsukuba, Dec. 2014.

33. Liu Huijun, Fumitoshi Yagishita, Shoko Ueta, Masaki Nishiuchi and Yasuhiko Kawamura : Synthesis, Structures and Optical Properties of Novel Fully Sybstituted 1,1'-(1,4-Phenylene)bis(pyrrole-3,4-dicarboxylate)., International Forum on Advanced Technologies, (巻), (号), (頁), Tokushima, March 2015.

34. Miyuki Oshimura, Keigo Motoyama, Hiroyuki Kitayama, Yoshihiko Ikeda, Tomohiro Hirano and Koichi Ute : Structural Determination of Novel Polyamine by Correlation Analysis of 1H NMR and Mass Spectra, 28th International Symposium for Polymer Analysis and Characterization (ISPAC-2015), Houston, June 2015.

35. Yuchin Hsu, Mingyeh Chuang, Miyuki Oshimura, Tomohiro Hirano and Koichi Ute : Analysis of Monomer Sequence of Copolymers Prepared by Various Polymer Reactions of Poly(Benzyl Methacrylate), 28th International Symposium for Polymer Analysis and Characterization (ISPAC-2015), Houston, June 2015.

36. Yukihiro Arakawa, Takahiro Oonishi, Takahiro Kohda, Keiji Minagawa and Yasushi Imada : Novel preparation method of flavinium organocatalysts, The 39th Naito Conference of the chemistry of organocatalysts, Sapporo, Japan, July 2015.

37. Tomohiro Hirano, Takuya Teramori, Miyuki Oshimura and Koichi Ute : Study on initiation reaction of polymerization of N-isopropylacrylamide with a bulky zincate complex, IUPAC International Symposium on Ionic Polymerization 2015 (IP15), Bordeaux, July 2015.

38. Keiji Minagawa, Mikito Yasuzawa, Yukihiro Arakawa, Yasushi Imada and Shingo Fujita : Design of Effective Chemistry Laboratory Class Based on Partnership among High School, University and Graduate School, Asia-Pacific Conference on Engineering & Applied Sciences (APCEAS2015), Osaka, Aug. 2015.

39. Masami Tanaka, Keiji Minagawa, Yukihiro Arakawa and Yasushi Imada : Analysis of Interaction between Diphenhydramine and Human Serum Albumin, Asia-Pacific Conference on Engineering & Applied Sciences (APCEAS2015), Osaka, Aug. 2015.

40. Koichi Ute : Characterization of Synthetic Polymers by Solution NMR: SEC-NMR, DOSY, and Multivariate Analysis, 2015 International Symposium on Nano Science and Technology, Tainan, Oct. 2015.

41. Takahiro Oonishi, Yukihiro Arakawa, Keiji Minagawa and Yasushi Imada : Development of Facile Method for Preparing Flavinium Organocatalysts, The 13th International Kyoto Conference on New Aspects of Organic Chemistry, Kyoto, Nov. 2015.

42. Takuma Tagami, Yukihiro Arakawa, Keiji Minagawa and Yasushi Imada : Flavin Catalyzed -Oxyamination of Aldehydes under Visible Light Irradiation, The 13th International Kyoto Conference on New Aspects of Organic Chemistry, Kyoto, Nov. 2015.

43. Miyuki Oshimura, Takahiro Hiura, Hikaru Momose, Yohei Miwa, Tomohiro Hirano and Koichi Ute : Preparation and Stereocomplexation of Poly(mandelic acid)s Obtained by Direct Polycondensation, 14th Pacific Polymer Conference, Kauai, Dec. 2015.

44. Junpei Hashimoto, Miyuki Oshimura, Tomohiro Hirano, Yoshihiro Uto and Koichi Ute : Stereospecific radical polymerization of methacrylamide derivatives in the presence of lithium salts, 14th Pacific Polymer Conference, Kauai, Dec. 2015.

45. Nenji Munekane, Miyuki Oshimura, Tomohiro Hirano and Koichi Ute : Radical copolymerization of methyl methacrylate and N-methylmethacrylamide in the presence of Li salt, 14th Pacific Polymer Conference, Kauai, Dec. 2015.

46. Yuta Ogasa, Tadashi Segata, Tomohiro Hirano and Koichi Ute : Chemoselective radical polymerization of N-allylmethacrylamide in the presence of Li salts, 14th Pacific Polymer Conference, Kauai, Dec. 2015.

47. Fumiya Semba, Hideyuki Uozumi, Miyuki Oshimura, Tomohiro Hirano and Koichi Ute : Modification of methacrylate copolymers having various monomer sequence and stereoregularity with D-glucosamine, 14th Pacific Polymer Conference, Kauai, Dec. 2015.

48. Yukihiro Arakawa, Shun Ueta, Keiji Minagawa and Yasushi Imada : Nucleophilic Addition to Nitrones Using Flow Microreactors, 2015 International Chemical Congress of Pacific Basin Societies, Honolulu, Hawaii, Dec. 2015.

49. Daichi Yokota, Yuka Nakanishi, Mitsuhiro Nagahama, Tomohiro Hirano and Koichi Ute : Monomer sequence in the poly(methyl methacrylate-co-benzyl methacrylate)s prepared by stepwise esterification of isotactic poly(methacrylic acid), Pacifichem2015 (The International Chemical Congress of Pacific Basin Societies), Waikiki, Dec. 2015.

50. Yuka Nakanishi, Yuchin Hsu, Toshiki Okubo, Miyuki Oshimura, Tomohiro Hirano and Koichi Ute : Monomer sequence in the poly(methyl methacrylate-co-benzyl methacrylate)s prepared by various polymer reactions of poly(benzyl methacrylate), Pacifichem2015 (The International Chemical Congress of Pacific Basin Societies), Waikiki, Dec. 2015.

51. Koto Suganuma, H. Cheng, Miyuki Oshimura, Tomohiro Hirano, Koichi Ute and Tetsuo Asakura : Analysis of stereoregularity in poly(lactic acid) by solution NMR, Pacifichem2015 (The International Chemical Congress of Pacific Basin Societies), Waikiki, Dec. 2015.

52. Takuma Tagami, Yukihiro Arakawa, Keiji Minagawa and Yasushi Imada : Visible Light-Induced alfa-Oxyamination of Aldehydes with Flavin Organocatalysts, 2015 International Chemical Congress of Pacific Basin Societies, Honolulu, Hawaii, Dec. 2015.

53. Takahiro Oonishi, Yukihiro Arakawa, Keiji Minagawa and Yasushi Imada : Facile Preparation of Flavinium Organocatalysts Utilizing Cation-Exchange Resins, 2015 International Chemical Congress of Pacific Basin Societies, Honolulu, Hawaii, Dec. 2015.

54. Yukihiro Arakawa, Tomohiro Mihara, Keiji Minagawa and Yasushi Imada : Flavin-Catalyzed Photoinduced Thioacetalization of Aldehydes, 2015 International Chemical Congress of Pacific Basin Societies, Honolulu, Hawaii, Dec. 2015.

55. Koichi Ute : Analysis of chemical structures of synthetic polymers by solution NMR: SEC-NMR, DOSY, and multivariate analysis, Pacifichem2015 (The International Chemical Congress of Pacific Basin Societies), Waikiki, Dec. 2015.

56. Islam Nazrul, Kinouchi Takashi, Fumitoshi Yagishita and Yasuhiko Kawamura : Thermal cyclotrimerization of tetraphenyl[5]cumulene to a tricyclodecadiene derivative, The International Chemical Congress of Pacific Basin Societies 2015, (都市), Dec. 2015.

57. Liu Huijun, Nii Chiho, Shoko Ueta, Fumitoshi Yagishita and Yasuhiko Kawamura : One-pot synthesis of novel polysubstituted 1,1-phenylene-bipyrrole via the double 1,3-dipolar cycloaddition reaction, The International Chemical Congress of Pacific Basin Societies 2015, Honolulu, Dec. 2015.

58. Hashizume Hirokazu, Omotani Keisuke, Shoko Ueta, Fumitoshi Yagishita and Yasuhiko Kawamura : Synthesis of the unsymmetrically substituted [4]radialene and its photochemical conversion to the light emissive pentacyclic compound, The international Chemical Congress of Pacific Basin Societies 2015, Honolulu, Dec. 2015.

59. Mifune Kazunori, Shimokawa Sota, Fumitoshi Yagishita and Yasuhiko Kawamura : Environmentally benign synthesis of benzoylated benzoin in the presence of thiazolium salt, The International Chemical Congress of Pacific Basin Societies 2015, Honolulu, Dec. 2015.

60. Shoko Ueta, Fumitoshi Yagishita, Masaki Nishiuchi and Yasuhiko Kawamura : Synthesis and function of a DNA cleaving molecule possessing phototriggering functionality via a Norrish type II reaction, The International Chemical Congress of Pacific Basin Societies 2015, Honolulu, Dec. 2015.

61. Watanabe Kohei, Ishikawa Hiroki, Uemura Naohiro, Fumitoshi Yagishita, Mino Takashi and Sakamoto Masami : Asymmetric synthesis of isoindolinones from achiral materials without an external chiral source, The International Chemical Congress of Pacific Basin Societies 2015, Honolulu, Dec. 2015.

62. Fumitoshi Yagishita, Kunito Yui, Kasashima Yoshio, Mino Takashi and Sakamoto Masami : Asymmetric stereoisomerization of achiral 3,4-diphenylsuccinimides involving dynamic preferential crystallization, The International Chemical Congress of Pacific Basin Societies 2015, Honolulu, Dec. 2015.

63. Fumitoshi Yagishita, Kozai Natsumi, Nomura Koh, Mino Takashi, Yasuhiko Kawamura and Sakamoto Masami : Imidazopyridine-palladium catalyzed Mizoroki-Heck reaction, The international Chemical Congress of Pacific Basin Societies 2015, Honolulu, (month)2015.

64. Masami Tanaka, Hiromichi Kenmoku, Keiji Minagawa, Yukihiro Arakawa and Yasushi Imada : Binding Property of Tripelennamine to Human Serum Albumin, 2nd International Forum on Advanced Technologies, (巻), (号), Tokushima, March 2016.

65. Jem-Kun Chen, Keiji Minagawa and Yasushi Imada : Reversibly Thermoswitchable Two-Dimensional Periodic Gratings Prepared from Tethered Poly(N isopropylacrylamide) on Silicon Surfaces, 2nd International Forum on Advanced Technologies, (巻), (号), Tokushima, March 2016.

66. Yuji Toda, Keiji Minagawa, Yukihiro Arakawa, Yasushi Imada and Masami Tanaka : Preparation of Thermoresponsive Nanocomposite Gels Utilizing Various Amphiphilic Monomers and Clay, 2nd International Forum on Advanced Technologies, (巻), (号), Tokushima, March 2016.

67. Yasuhiko Kawamura, Fumitoshi Yagishita, Hirokazu Hashizume, Yoshihiko Tezuka, Shoko Ueta and Shuichi Hashimoto : Reactions of Cumulated Double Bonds: Building Higher Organinc Molecules Leading to Functionalized Materials, 2nd International Forum on Advanced Technologies, (巻), (号), pp.141-142, Tokushima, March 2016.

【特許・実用新案】

1. 平野 朋広, 右手 浩一, 佐藤 恒之, 原口 将幸, 大土井 啓祐 : 高分岐ポリマーを用いた光パターニング組成物, 特願2008-186586 (2008年7月), 特開2010-24330 (2010年2月), 特許第5473270号 (2014年2月).

2. 百瀬 陽, 右手 浩一, 平野 朋広 : 共重合体の定量方法, 特願2009-252192 (2009年11月), 特開2011-085564 (2011年4月), 特許第5531563号 (2014年5月).

3. 原口 将幸, 大土井 啓祐, 平野 朋広, 右手 浩一, 佐藤 恒之 : 高分岐ポリマー及びそれを含む組成物, 特願PCT/JP2010/061623 (2010年7月), 特開WO2011/004865 (2011年1月), 特許第5651111号 (2014年11月).

4. 平野 朋広, 右手 浩一, 佐藤 恒之, 原口 将幸, 畑中 辰也, 大土井 啓祐 : イオン性高分岐ポリマー及び炭素ナノ材料分散剤, 特願2010-161021 (2010年7月), 特開2012-21100 (2012年2月), 特許第5676170号 (2015年1月).

5. 右手 浩一, 平野 朋広, 押村 美幸, 加地 栄一 : 新規エステル交換反応用触媒およびそれを用いたエステル化合物の製造方法, 特願2014-172501 (2014年8月), 特開2016-47799 (2016年4月), (番号) ((年月日)).

6. 北尾久平 (名), 今田 泰嗣, 荒川 幸弘 : ジエポキシ化合物の製造方法, 特願2015-079601 (2015年4月), (開示), (番号) ((年月日)).

II.4.2 物質機能化学

当大講座では，新規酵素センサーおよび金属イオン計測用センサーの開発，金属錯体の電気化学的特性評価，高温高圧流体中での反応，タンパク質の結晶成長および結晶構造解析，体内埋込型マイクロバイオセンサの開発，機能性層状複水酸化物超微粒子の合成等に関する研究を実施している．

II.4.2.1 教員組織

(1) 氏名，(2) メールアドレス，(3) 職名・学位，(4) 専門分野，(5) 所属学会（役職名），(6) 社会活動（役職名），(7) 主要研究テーマ，(8) キーワード，(9) 共同研究可能テーマ

(1) 髙栁 俊夫, Toshio Takayanagi, (2) tōśhīō ₍.₎ tākāyāņāġī (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 教授・博士(工学), (4) 分析化学, (5) 日本分析化学会 (代議員, 第63年会 実行委員, 「ぶんせき」編集委員)・日本分析化学会 中国四国支部 (常任幹事)・日本分析化学会 電気泳動分析研究懇談会 (委員, 若手ワーキング, 第36回キャピラリー電気泳動シンポジウム 実行委員長)・日本分析化学会 フローインジェクション分析研究懇談会 (編集委員, 委員)・日本分析化学会 環境分析研究懇談会・社団法人 日本化学会・日本化学会 中国四国支部 (地区幹事)・クロマトグラフィー科学会 (評議員, 編集委員)・アメリカ化学会・岡山地区分析技術懇談会・フラーレン・ナノチューブ・グラフェン学会・徳島地区分析技術研究会 (委員, 事務局), (6) 阿南市水道水源保護審議会 (委員, 調査研究部会委員)・徳島大学工業会 (学内理事)・教員免許状更新講習説明会 (講師), (7) システム論的手法に基づく分離法，分析法の開発, (8) キャピラリー電気泳動, フローインジェクション分析, グリーン分析化学, (9) (@.collaborate)

(1) 岡村 英一, Hidekazu Okamura, (2) hō (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 教授・Ph.D. (Physics)・工学修士(応用物理学), (4) 光物性, (5) 公益社団法人 日本化学会・日本物理学会・日本放射光学会・日本高圧力学会・日本赤外線学会, (6) 高輝度光科学研究センター, (7) シンクロトロン放射光などを用いた光物性研究, (8) 光物性, シンクロトロン放射光, 赤外分光法, 高圧力, 強相関電子系, (9) (@.collaborate)

(1) 安澤 幹人, Mikito Yasuzawa, (2) yāśūżāwā (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 教授・博士(工学), (4) 電気化学, バイオマテリアル, (5) 社団法人 日本化学会・日本バイオマテリアル学会・社団法人 電気化学会 (関西支部幹事)・国際電気化学会・化学センサ研究会 (編集委員)・アメリカ電気化学会・日本分析化学会・日本ポーラログラフ学会, (6) , (7) 埋込型微小血糖値センサの作製, 免疫センサの開発, SPE電極を用いた有機合成, 生体適合性材料の合成, 磁気回収が可能な水質浄化用低環境負荷型凝集剤の開発, (8) バイオセンサ, 電解合成, インビボ測定, 生体適合性材料, SPE電解, 水質浄化, (9) 体内リアルタイム測定用バイオセンサ, 小型環境モニタリングシステム, 支持塩を使わない電解合成, 生体適合性材料

(1) 鈴木 良尚, Yoshihisa Suzuki, (2) yōśhīś (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 准教授・博士(理学), (4) 結晶成長学, (5) 日本物理学会 (領域9世話人(2002年5月∼2003年4月), 領域9領域運営委員(2010年10月∼2011年11月))・社団法人 日本化学会・日本結晶成長学会 (編集委員(2010年4月∼2013年3月), 理事(教育公益委員会)(2013年4月∼2016年3月))・社団法人 化学工学会・日本高圧力学会・American Physical Society, (6) 日本物理学会 (領域9世話人(2002年5月∼2003年4月)), (7) 生体高分子の結晶化, コロイド結晶, 生体高分子の熱測定, 高圧力下での結晶成長, (8) タンパク質結晶成長, コロイド結晶, 高圧力科学, 示差走査熱量計, (9) タンパク質の熱変成, 結晶溶解挙動の研究, 結晶成長過程の研究

(1) 吉田 健, Ken Yoshida, (2) yōśhīđā ₍.₎ kėņ (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 講師・博士(理学), (4) 物理化学, 溶液化学, (5) 社団法人 日本化学会・日本高圧力学会 (第55回高圧討論会実行委員)・溶液化学研究会 (第38回溶液化学シンポジウム実行委員)・日本学術振興会 蒸気性質 第139委員会 (委員)・日本学術振興会 蒸気性質 第139委員会 高温・高圧化学分科会 (委員)・国際水・蒸気性質協会 水溶液の物理化学 専門委員会 (委員)・日本高圧力学会 (評議員)・日本学術振興会 蒸気性質 第139委員会 (幹事), (6) 社団法人 日本化学会, (7) 液体，流体中の物理化学, (8) (@.keyword), (9) (@.collaborate)

(1) 水口 仁志, Hitoshi Mizuguchi, (2) mīżū (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 講師・博士(工学), (4) (@.field), (5) , (6) , (7) (@.theme), (8) (@.keyword), (9) (@.collaborate)

(1) 倉科 昌, Masashi Kurashina, (2) kūŗāśhīņā ₍.₎ māśāśhī (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 助教・博士(理学), (4) 無機化学, 錯体化学, (5) 社団法人 日本化学会・錯体化学会・日本粘土学会, (6) , (7) 金属イオンを配列制御した材料の電子・磁気物性, (8) 遷移金属イオン, 電子的相互作用, 磁性, 層状化合物, (9) 層状化合物や遷移金属化合物の合成と物性

II.4.2.2 研究業績

【著　　書】

1. 安澤 幹人 : 体内埋め込み測定用バイオセンサの開発, 株式会社 技術情報協会, 東京, 2014年4月.

2. 吉田 健, 中原 勝 : 極限環境の生体分子 過酷な環境下での機能を科学する(CSJカレントレビュー17)，2章 Basic concept-1, 高圧力の化学の基礎, 株式会社 化学同人, 京都, 2014年11月.

3. 中原 勝, 吉田 健 : 理科年表 平成28年版, --- 物理/化学部 502∼509頁「熱化学」，514∼517頁「電気化学・溶液化学『溶解度』『難溶塩の溶解度積』」 ---, 丸善出版 株式会社, 東京, 2015年12月.

【学術論文】

1. Ken Yoshida, Nobuyuki Matubayasi, Yasuhiro Uosaki and Masaru Nakahara : Effect of heavy hydrogen isotopes on the vibrational line shape for supercritical water through rotational couplings, The Journal of Chemical Physics, Vol.138, No.13, p.134508, 2013.

2. Toshio Takayanagi, Ayumi Tabara and Takashi Kaneta : Determination of Acid Dissociation Constant of Degradable Tetrabromophenolphthalein Ethyl Ester by Capillary Zone Electrophoresis, Analytical Sciences, Vol.29, No.5, pp.547-552, 2013.

3. Atsushi Mori and Yoshihisa Suzuki : Grand potential formalism of interfacial thermodynamics for critical nucleus, Natural Science, Vol.5, No.5, pp.631-639, 2013.

4. Atsushi SASAKI, Eishi YOSHIKAWA, Hitoshi Mizuguchi and Masatoshi ENDO : The improvement of water quality in an acidic river environment using waste concrete aggregates, Journal of Water and Environment Technology, Vol.11, No.3, pp.235-247, 2013.

5. G. Inoue, T. Kaneta, Toshio Takayanagi, J. Kakehi, H. Motose and T. Takahashi : Determination of polyamines in Arabidopsis thaliana by capillary electrophoresis using salicylaldehyde-5-sulfonate as a derivatizing reagent, Analytical Methods, Vol.5, No.11, pp.2854-2859, 2013.

6. Ye Yin, Toshio Takayanagi, Mitsuko Oshima, Koji Oshita, Shoji Motomizu and Yoshiyuki Murata : Determination of Ultra-Trace Amounts of Lead in River Water by Flow Injection Analysis Coupled with Computer-Controlled Auto-Pretreatment System Using Solid Phase Extraction Procedure, Journal of Flow Injection Analysis, Vol.30, No.1, pp.45-50, 2013.

7. Atsushi Mori and Yoshihisa Suzuki : Vanishing linear term in chemical potential difference in volume term of work of critical nucleus formation for phase transition without volume change, Journal of Crystal Growth, Vol.375, No.1, pp.16-19, 2013.

8. Masahide Sato, Hiroyasu Katsuno and Yoshihisa Suzuki : Crystallization of Brownian Particles from Walls Induced by a Uniform External Force, Journal of the Physical Society of Japan, Vol.82, No.8, pp.084804-1-084804-8, 2013.

9. 舟山 剛史, 水口 仁志, 志田 惇一 : メンブランフィルターへの固相抽出によるAs(III)およびAs(V)の目視分別分析, 分析化学, Vol.62, No.8, 685-691頁, 2013年.

10. 渡邊 修, 久松 亨, 水口 仁志, 飯山 真充 : 多孔質膜金電極における陽極溶出ボルタンメトリーによる高濃度アルカリ水溶液中の微量銅イオンの定量, 分析化学, Vol.62, No.8, 707-712頁, 2013年.

11. Toshio Takayanagi, Masaki Morimoto and Tomoki Yabutani : Micellar Electrokinetic Chromatography of Graphene and Chemically Modified Graphenes with Dodecylbenzenesulfonate, Analytical Sciences, Vol.29, No.8, pp.769-771, 2013.

12. Le Thi Xuan Thuy, Mikito Yasuzawa and Tomoki Yabutani : Magnetic Removal of Cesium Ions Using γ-Poly(glutamic acid)-Coated Magnetite Particles with the Enhanced Effect of Zeolite Supplementation, Bulletin of the Chemical Society of Japan, Vol.86, No.8, pp.958-962, 2013.

13. Yoshihisa Suzuki, Gen Sazaki, Kaori Hashimoto, Takahisa Fujiwara and Yoshinori Furukawa : Colloidal crystallization utilizing interfaces of unidirectionally growing ice crystals, Journal of Crystal Growth, Vol.383, pp.67-71, 2013.

14. Hitoshi Mizuguchi, Jun SAKURAI, Yuki KINOSHITA, Masamitsu IIYAMA, Tatsuro KIJIMA, Kazuhiro TACHIBANA, Tatsuo NISHINA and Junihi SHIDA : Flow-based Biosensing System for Glucose Fabricated by Using Track-etched Microporous Membrane Electrodes, Chemistry Letters, Vol.42, No.10, pp.1317-1319, 2013.

15. Hitoshi Mizuguchi, Kentaro NUMATA, Chiaki MONMA, Masamitsu IIYAMA, Kazuhiro TACHIBANA, Tatsuo NISHINA and Junichi SHIDA : Determination of Ultra-Trace Mercury(II) by Flow-injection/Anodic Stripping Voltammetry Using a Track-etched Microporous Membrane Electrode, Analytical Sciences, Vol.29, No.10, pp.949-954, 2013.

16. Hiroshi Kimura, Ken Yoshida, Yasuhiro Uosaki and Masaru Nakahara : Effect of Water Content on Conversion of D-Cellobiose into 5-Hydroxymethyl-2-furaldehyde in DimethylsulfoxideWater Mixture, The Journal of Physical Chemistry A, Vol.117, No.43, pp.10987-10996, 2013.

17. Izumi Yoshizaki, Katsuo Tsukamoto, Tomoya Yamazaki, Kenta Murayama, Kentaro Oshi, Seijiro Fukuyama, Taro Shimaoka, Yoshihisa Suzuki and Masaru Tachibana : Growth rate measurements of lysozyme crystals under microgravity conditions by laser interferometry, The Review of Scientific Instruments, Vol.84, pp.103707-1-103707-8, 2013.

18. Toshio Takayanagi : Analysis of Fast and Slow Acid Dissociation Equilibria of 3',3'',5',5''-Tetrabromophenolphthalein and Determination of Its Equilibrium Constants by Capillary Zone Electrophoresis, Analytical Sciences, Vol.29, No.11, pp.1067-1073, 2013.

19. Hiroshi Kimura, Masaki Hirayama, Ken Yoshida, Yasuhiro Uosaki and Masaru Nakahara : Effect of Water on Hydrolytic Cleavage of Non-Terminal α-Glycosidic Bonds in Cyclodextrins To Generate Monosaccharides and Their Derivatives in a Dimethyl SulfoxideWater Mixture, The Journal of Physical Chemistry A, Vol.118, No.8, pp.1309-1319, 2014.

20. Kazuaki Edagawa, Yusuke Fuchiwaki and Mikito Yasuzawa : In Vivo Evaluation of Fine Needle Amperometric Glucose Sensors Implanted in Rabbit's Blood Vessel, Journal of the Electrochemical Society, Vol.161, No.2, pp.B3111-B3115, 2014.

21. Hiroki Ishikawa, Hitoshi Takagi, Antonio Norio Nakagaito, Mikito Yasuzawa, Hiroaki Genta and Hiroshi Saito : Effect of surface treatments on the mechanical properties of natural fiber textile composites made by VaRTM method, Composite Interfaces, Vol.21, No.4, pp.329-336, 2014.

22. Mamoru Fujine, Masahide Sato, Hiroyasu Katsuno and Yoshihisa Suzuki : Effect of container shape and walls on solidification of Brownian particles in a narrow system, Physical Review E, Statistical, Nonlinear, and Soft Matter Physics, Vol.89, p.042401, 2014.

23. Atsushi Mori, Yoshihisa Suzuki and Masahide Sato : Gravitational Tempering in Colloidal Epitaxy To Reduce Defects Further, Crystal Growth & Design, Vol.14, No.5, pp.2083-2086, 2014.

24. 水口 仁志, 篠田 靖子, 我妻 孝佳, 高田 雅之, 上條 利夫, 志田 惇一 : 同種金属二核錯体系を用いるイオン交換体比色法によるppbレベルの鉄(III)イオンの目視閾値判定, 分析化学, Vol.63, No.6, 515-523頁, 2014年.

25. Ken-Ichiro Sotowa, Takahiro Togawa, Yuika Shimizu, Masashi Kurashina, Toshihide Horikawa and Jesus Rafael Alcantara Avila : Effect of Mixing Methods on the Precipitation of Basic Copper Acetate, Applied Mechanics and Materials, Vol.625, (号), pp.201-204, 2014.

26. Beyene Moges, Bemnet Amare, Tomoki Yabutani and Afework Kassu : HIV associated hypocalcaemia among diarrheic patients in northwest Ethiopia: a cross sectional study, BMC Public Health, Vol.14, (号), p.679, 2014.

27. 島上 夏美, 薮谷 智規, 髙栁 俊夫 : キャピラリーゾーン電気泳動法を用いる電気泳動移動度の測定による光分解性ハロペリドールの酸解離反応解析, 分析化学, Vol.63, No.8, 643-648頁, 2014年.

28. Yoshihisa Suzuki, Atsushi Mori, Masahide Sato, Hiroyasu Katsuno and Tsutomu Sawada : Colloidal crystallization on tilted substrates under gravitational fields, Journal of Crystal Growth, Vol.401, No.1, pp.905-909, 2014.

29. Masahide Sato, Hiroyasu Katsuno and Yoshihisa Suzuki : Ordering of Brownian Particles from Walls Due to an External Force, Journal of Crystal Growth, Vol.401, pp.87-92, 2014.

30. Ken Yoshida, Nobuyuki Matubayasi, Yasuhiro Uosaki and Masaru Nakahara : Effect of Rotational Couplings on Vibrational Spectrum Line Shape of Bending Mode in Low-Density Supercritical Water: Density and Hydrogen Isotopes Dependencies, Journal of Solution Chemistry, Vol.43, No.9-10, pp.1499-1508, 2014.

31. Toshio Takayanagi, Kinuyo Ogura and Tomoki Yabutani : Analysis of Ion-association Equilibrium of Precipitable Dipicrylaminate Ion in Aqueous Solution by Capillary Zone Electrophoresis, Analytical Sciences, Vol.30, No.9, pp.919-924, 2014.

32. Haruhiko Koizumi, Masaru Tachibana, Izumi Yoshizaki, Seijiro Fukuyama, Katsuo Tsukamoto, Yoshihisa Suzuki, Satoshi Uda and Kenichi Kojima : Dislocations in High-quality Glucose Isomerase Crystals Grown from Seed Crystals, Crystal Growth & Design, Vol.14, No.10, pp.5111-.5116, 2014.

33. Mamoru Fujine, Masahide Sato, Tetsuya Toyooka, Hiroyasu Katsuno, Yoshihisa Suzuki and Tsutomu Sawada : Crystallization of Brownian particles in thin systems constrained by walls, Physical Review E, Statistical, Nonlinear, and Soft Matter Physics, Vol.90, pp.032404-1-.032404-7, 2014.

34. Tomohiro Hirano, Yuya Miyamoto, Shinya Amano, Kazuya Tatsumi, Takuya Anmoto, Hiroshi Kimura, Ken Yoshida, Miyuki Oshimura and Koichi Ute : Hydrogen-bond-assisted isotactic-specific radical polymerization of N-vinyl-2-pyrrolidone with tartrate additives in toluene at low temperatures: high-resolution 1H NMR analysis, RSC Advances, Vol.4, No.95, pp.53079-53089, 2014.

35. Tomoki Yabutani, Geoffrey Waterhouse, Dongxiao Sun-Waterhouse, James B. Metson, Iinuma Akiko, Le Thi Xuan Thuy, Yohei Yamada, Toshio Takayanagi and Junko Motonaka : Facile synthesis of platinum nanoparticle-containing porous carbons and their application in amperometric glucose biosensing, Mikrochimica Acta, Vol.181, No.5, pp.1871-1878, 2014.

36. Atsushi Mori and Yoshihisa Suzuki : Identification of triangular-shaped defects often appeared in hard-sphere crystals grown on a square pattern under gravity by Monte Carlo simulations, Physica B : Condensed Matter, Vol.452, No.1, pp.58-65, 2014.

37. Tomoki Yabutani, Yuji Inoi, Ayumi Kimura, Yohei Yamada and Toshio Takayanagi : Speciation of Chromium(VI) and Selenium(IV and VI) by High-Performance Liquid Chromatography-Fluorometric Detection Using 2,3-Diaminonaphthalene as a Single Derivatizing Reagent, Bulletin of the Chemical Society of Japan, Vol.87, No.12, pp.1402-1406, 2014.

38. Toshio Takayanagi, Genki Inoue and Ayumi Ikuta : Analysis of Binding Equilibrium of Phenylalkylamines to Brij 58 Micelle through the Measurement of Electrophoretic Mobility by CZE, Chromatography, Vol.35, No.3, pp.147-154, 2014.

39. Masatoshi ENDO, Naoki SUGAI, Kazuhiro KIKUCHI, Masaru SANJO, Hitoshi Mizuguchi and Atsushi SASAKI : Variation of Water Quality Arising from the Hydrolysis of Aluminum in the Acidified River, Journal of Water and Environment Technology, Vol.13, No.2, pp.141-152, 2015.

40. 髙栁 俊夫 : キャピラリーゾーン電気泳動法を活用する副反応進行下での水溶液内平衡反応の解析, 分析化学, Vol.64, No.2, 105-116頁, 2015年.

41. Mikito Yasuzawa, Toba Taketo, Hiura Kentaro, Li Jiang, Pankaj M. Koinkar, Tomoyuki Ueki and Fuchiwaki Yusuke : Preparation of micro-biosensor for continuous glucose monitoring, Modern Physics Letters. B, Vol.29, No.6-7, p.1540040, 2015.

42. Masashi Kurashina, Tatsuki Inoue, Chihiro Tajima and Eiji Kanezaki : Removal of borate by coprecipitation with Mg/Al layered double hydroxide, Modern Physics Letters. B, Vol.29, No.6 & 7, p.1540031, 2015.

43. Tomoki Yabutani, Takamasa Nakamura and Toshio Takayanagi : Leaching of metals from steel samples in peracetic acid, Modern Physics Letters. B, Vol.29, No.6&7, p.1540038, 2015.

44. Yamanoi Yoshinori, Takahashi Kazuhiro, Hamada Takeshi, Ohshima Norikazu, Masashi Kurashina, Hattori Yohei, Kusamoto Tetsuro, Sakamoto Ryota, Miyachi Mariko and Nishihara Hiroshi : Synthesis, characterization, and physical properties of oligo(1-(N,N-dimethylamino)pyrrole)s and their doped forms, precursors of candidates for molecular flat-band ferromagnets, Journal of Materials Chemistry. C, Materials for Optical and Electronic Devices, Vol.3, No.17, pp.4316-4320, 2015.

45. Ogawa Yuki, Masashi Kurashina, Eiji Kanezaki and Takashi Yamamoto : Effect of Aging Method on Adsorption and Elution of Phosphate in Mg/Fe Layered Double Hydroxide, Advanced Materials Research, Vol.1110, pp.287-290, 2015.

46. Ikemoto Yuka, Hidekazu Okamura, Moriwaki Taro, Suto Hitoshi and Kinoshita Toyohiko : Improvement of infrared near-field spectrum by asymmetric interferometer configuration, Japanese Journal of Applied Physics, Vol.54, pp.082402-1-082402-5, 2015.

47. Takahisa Fujiwara, Yoshihisa Suzuki, Izumi Yoshizaki, Katsuo Tsukamoto, Kenta Murayama, Seijiro Fukuyama, Kouhei Hosokawa, Kentaro Oshi, Daisuke Ito, Tomoya Yamazaki, Masaru Tachibana and Hitoshi Miura : Correction of the equilibrium temperature caused by slight evaporation of water in protein crystal growth cells during long-term space experiments at International Space Station, The Review of Scientific Instruments, Vol.86, pp.083704-1-083704-6, 2015.

48. Kazuhisa Hirabayashi, Kenjiro Hanaoka, Toshio Takayanagi, Yuko Toki, Takahiro Egawa, Mako Kamiya, Toru Komatsu, Tasuku Ueno, Takuya Terai, Kengo Yoshida, Masanobu Uchiyama, Tetsuo Nagano and Yasuteru Urano : Analysis of Chemical Equilibrium of Silicon-Substituted Fluorescein and Its Application to Develop a Scaffold for Red Fluorescent Probes, Analytical Chemistry, Vol.87, No.17, pp.9061-9069, 2015.

49. Hashimoto K., Kobayashi R., Hidekazu Okamura, Taniguchi H. and Ikemoto Y. : Emergence of charge degrees of freedom under high pressure in the organic dimer-Mott insulator beta'-(BEDT-TTF)2ICl2, Physical Review B, Condensed Matter and Materials Physics, Vol.92, pp.085149-1-085149-7, 2015.

50. Yoshihisa Suzuki, Katsuo Tsukamoto, Izumi Yoshizaki, Hitoshi Miura and Takahisa Fujiwara : First Direct Observation of Impurity Effects on the Growth Rate of Tetragonal Lysozyme Crystals under Microgravity as Measured by Interferometry, Crystal Growth & Design, Vol.15, pp.4787-4794, 2015.

51. Keiji Minagawa, Mikito Yasuzawa, Yukihiro Arakawa, Yasushi Imada and Shingo Fujita : Design of Effective Chemistry Laboratory Class Based on Partnership among High School, University and Graduate School, IMPACT : International Journal of Research in Applied, Natural and Social Sciences, Vol.3, No.10, pp.121-124, 2015.

52. Toshio Takayanagi, Mika AMIYA, Natsumi SHIMAKAMI and Tomoki Yabutani : Determination of Acid Dissociation Constant of Pravastatin under Degraded Conditions by Capillary Zone Electrophoresis, Analytical Sciences, Vol.31, No.11, pp.1193-1196, 2015.

53. Mikito Yasuzawa, Yuya Omura, Kentaro Hiura, Jiang Li, Yusuke Fuchiwaki and Masato Tanaka : Fabrication of Amperometric Glucose Sensor Using Glucose Oxidase-Cellulose Nanofiber Aqueous Solution, Analytical Sciences, Vol.31, No.11, pp.1111-1114, 2015.

54. Takuya Ehiro, Ai Itagaki, Masashi Kurashina, Masahiro Katoh, Keizo Nakagawa, Yuuki Katou, Wataru Ninomiya and Shigeru Sugiyama : Effect of the Template Ion Exchange Behaviors of Chromium into FSM-16 on the Oxidative Dehydrogenation of Isobutane, Journal of the Ceramic Society of Japan, Vol.123, No.12, pp.1084-1089, 2015.

55. Jiang Li, Kentaro Hiura, Mikito Yasuzawa and Yusuke Fuchiwaki : Fabrication of Low-Invasive Patch Glucose Sensors, ECS Transactions, Vol.69, No.37, pp.1-5, 2015.

56. Takuya Ehiro, Ai Itagaki, Hisanobu Misu, Masashi Kurashina, Keizo Nakagawa, Masahiro Katoh, Yuuki Katou, Wataru Ninomiya and Shigeru Sugiyama : Oxidative Dehydrogenation of Isobutane to Isobutene on Metal-doped MCM-41 Catalysts, Journal of Chemical Engineering of Japan, Vol.49, No.2, pp.136-143, 2016.

【総説・解説】

1. 水口 仁志 : ペルオキシダーゼを模倣したナノ粒子触媒を利用するバイオセンサー, ぶんせき, Vol.2013, No.6, 352-353頁, 2013年6月.

2. 鈴木 良尚, 佐崎 元, 藤原 貴久, 塚本 雅之 : 圧力を使ったタンパク質の結晶成長の研究, 日本結晶成長学会誌, Vol.40, No.2, 107-114頁, 2013年7月.

3. 倉科 昌 : 注目の論文 100倍に膨らむ無機層状物質, --- 瞬く間に膨らんで，またもとどおり ---, 化学, Vol.68, No.8, 61-62頁, 2013年8月.

4. 吉田 健, 魚崎 泰弘 : 鉄で水素を貯蔵する-水素の「化学タンク」となるギ酸の合成, 化学, Vol.68, No.10, 63-64頁, 2013年10月.

5. 水口 仁志 : トラックエッチ膜フィルター電極を用いるフロー型電気化学分析法の開発, 化学センサ, Vol.29, No.4, 108-115頁, 2013年12月.

6. 吉田 健 : 超臨界水中の伸縮振動の分子描像 ──振動スペクトル波形を決める動的な起源の解明, 化学と工業, Vol.67, No.3, 250-251頁, 2014年3月.

7. Hitoshi Mizuguchi : Track-Etched Microporous Membrane Electrodes and Its Applications in Flow Analysis, Journal of Flow Injection Analysis, Vol.31, No.1, pp.19-25, June 2014.

8. 鈴木 良尚, 塚本 勝男, 吉崎 泉, 福山 誠二郎, 橘 勝, 小泉 晴比古, 藤原 貴久, 塩澤 宏章, 植原 悠太, 塩本 知弘, 中橋 大道 : グルコースイソメラーゼの結晶化に及ぼす微小重力効果, --- Nanostep 2 プロジェクト提案に向けた共同研究 ---, International Journal of Microgravity Science and Application, Vol.31, No.3, 124-129頁, 2014年6月.

9. 塚本 勝男, 三浦 均, 鈴木 良尚, 村山 健太, 藤原 貴久, 吉崎 泉 : 地上とKiboで精密測定されたリゾチーム結晶成長速度, Space Utilization Research, Vol.29, No.3, 35-37頁, 2015年1月.

10. 鈴木 良尚, 塚本 勝男, 吉崎 泉, 福山 誠二郎, 藤原 貴久, 柳谷 伸一郎, 橘 勝, 小泉 晴比古 : 溶液相の状態変化によるタンパク質結晶の界面成長kineticsおよび界面morphologyの変化, Space Utilization Research, Vol.29, No.3, 53-56頁, 2015年1月.

11. 鈴木 良尚, 藤原 貴久 : 溶解度・結晶成長速度の圧力依存性から見る水和・脱水和プロセス, 日本結晶成長学会誌, Vol.42, No.4, 274-282頁, 2016年1月.

【国際会議 Proceedings】

1. Yusuke Tanatsugu, Shinsuke Nakanishi, Kiyoto Ikebata, Kotaro Rikitake and Mikito Yasuzawa : Preparation and evaluation of biocompatible surface using perhydropolysilazane, 245th ACS National Meeting and Exposition, New Orleans, April 2013.

2. Kazuaki Edagawa, Hiroki Takaoka, Tomoki Yabutani and Mikito Yasuzawa : Preparation of Fine Implantable Needle-Type Glucose Lactate Dual Biosensors Using γ-Polyglutamic Acid, 223rd ECS Meeting, Toronto, May 2013.

3. Kentaro Hiura, Shinya Furukawa, Kazuaki Edagawa and Mikito Yasuzawa : Preparation of Enzyme-Immobilized Biosensor by the Combination of Electrodeposition and Electropolymerization, 223rd ECS Meeting, Toronto, May 2013.

4. Ken Yoshida, Nobuyuki Matubayasi, Yasuhiro Uosaki and Masaru Nakahara : Vibrational Spectrum Line Shape for Supercritical Water: Effect of Rotational Couplings on Density, Temperature, and Hydrogen Isotopes Dependencies, 33rd International Conference on Solution Chemistry, Kyoto, July 2013.

5. Katsuo Tsukamoto, Izumi Yoshizaki, Yoshihisa Suzuki, Hitoshi Miura, Gen Sazaki, Masaru Tachibana, Kentaro Oshi and Manuel Juan Garcia-Ruiz : Growth Mechanism of Lysozyme Crystals in The International Space Station Based on The Analysis of In-Situ Interferometric Observation, The 17th International Conference on Crystal Growth and Epitaxy, (巻), (号), (頁), Warsaw, Aug. 2013.

6. Masahide Sato, Hiroyasu Katsuno and Yoshihisa Suzuki : Ordering of Brownian Particles from Walls Due to an External Force, The 17th International Conference on Crystal Growth and Epitaxy, (巻), (号), (頁), Warsaw, Aug. 2013.

7. Yoshihisa Suzuki, Jin Endoh, Yohei Hamada, Atsushi Mori, Masahide Sato and Hiroyasu Katsuno : Crystallization and annealing of colloidal crystals under gravitational field, The 17th International Conference on Crystal Growth and Epitaxy, (巻), (号), (頁), Warsaw, Aug. 2013.

8. Toshio Takayanagi, Kinuyo Ogura and Tomoki Yabutani : Ion-Association Analysis of Dipicrylaminate Ion in an Aqueous Solution by Capillary Zone Electrophoresis, ASIANALYSIS XII The Twelfth Asian Conferece on Analytical Sciences, Fukuoka, Aug. 2013.

9. Shinji Nishimae, Yoshihumi Isobe, Tomoki Yabutani, Toshio Takayanagi, Tomohiro Hirano and Koichi Ute : Poyion Complxes Formed between Hyper-branched Polyelectrolytes Synthesized by Ininiator-Fragment Incorporation Radical Polymerization Method, ASIANALYSIS XII The Twelfth Asian Conference on Analytical Sciences, Fukuoka, Aug. 2013.

10. Yuji Inoi, Ayumi Kimura, Tomoki Yabutani and Toshio Takayanagi : Fluorimetric Determination of Hexavalent Chromate Ion Using 2,3-Diaminonaphthalene and Hydroxylamine Hydrochroride, ASIANALYSIS XII The Twelfth Asian Conference on Analytical Sciences, Fukuoka, Aug. 2013.

11. Toshio Takayanagi, Masaki Morimoto and Tomoki Yabutani : Micellar Electrokinetic Chromatography of Graphene and Chemically Modified Graphene, ASIANALYSIS XII The Twelfth Asian Conference on Analytical Sciences, Fukuoka, Aug. 2013.

12. Tomoki Yabutani, Chihiro Mukuta, Masashi Konishi, Yohei Yamada and Toshio Takayanagi : Selective Separation of Oxoanion-Forming Elements Adsorbed on Solid States by Using Hydrogen Peroxide as Eluent, ASIANALYSIS XII The Twelfth Asian Conference on Analytical Sciences, Fukuoka, Aug. 2013.

13. Toshio Takayanagi : Aquatic Analysis of Bromate Ion and Perfluorinated Surfactants on the Basis of Photometric Detection for Environmentally Friendly Analysis, 2013 CJK Symposium The 10th China-Japan-Korea Symposium on Analytical Chemistry /ASIANALYSIS XII, (都市), Aug. 2013.

14. Ken Yoshida, Masashi Katanazaka, Hiroshi Kimura, Yasuhiro Uosaki and Masaru Nakahara : HIGH-PURITY HYDORGEN PRODUCTION FROM FORMIC ACID USING ZINC (II) CATION AS HOMOGENEOUS CATALYST, 16th International Conference on the Properties of Water and Steam, (都市), Sep. 2013.

15. Yohei Yamada, Yuki Ohnishi, Mari Nakashima, Katsuhito Tanaka, Toshio Watanabe, Haruhiko Sakuraba, Toshio Takayanagi and Tomoki Yabutani : Amperometric Determination of Branched Amino Acids by High Performance Liquid chromatograph with L-leusine Dehydrogenase / Diapholase Immobilized Electrode as A Detector, RSC Tokyo International Conference 2013 - Analytical Biochemistry & Biophysics -, Chiba, Sep. 2013.

16. Ken Yoshida, Nobuyuki Matubayasi, Yasuhiro Uosaki and Masaru Nakahara : INFRARED SPECTRUM LINE SHAPE FOR SUPERCRITICAL WATER STUDIED BY MOLECULAR DYNAMICS SIMULATION: THE EFFECT OF THE ROTATIONAL COUPLINGS, 16th International Conference on the Properties of Water and Steam, (巻), (号), (頁), (都市), Sep. 2013.

17. Hitoshi Mizuguchi, Jun SAKURAI, Yuki KINOSHITA, Misamitsu IIYAMA, Tatsuro KIJIMA, Kazuhiro TACHIBANA, Tatsuo NISHINA and Junichi SHIDA : Amperometric glucose biosensor fabricated using track-etched microporous membrane electrodes, 18th International Conference on Flow Injection Analysis (18th ICFIA), Porto, Sep. 2013.

18. Hitoshi Mizuguchi : Amperometric Flow Sensor Fabricated Using Track-etched Microporous Membrane Electrodes, International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan, Sendai, Sep. 2013.

19. Kentaro NUMATA, Chiaki MONMA, Hitoshi Mizuguchi, Masamitsu IIYAMA, Kazuhiro TACHIBANA, Tatsuo NISHINA and Junichi SHIDA : Flow injection/anodic stripping voltammetry for the detection of ultra-trace mercury(II) by using track-etched microporous membrane electrodes, International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan, Sendai, Sep. 2013.

20. Shinya SATO, Tomomi SATO, Genki HAYAKAWA and Hitoshi Mizuguchi : Surface modification of track-etched microporous membrane electrodes by electrochemical reduction of diazonium cations, International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan, Sendai, Sep. 2013.

21. Satoshi Kubota, Toshihide Horikawa, Ken-Ichiro Sotowa and Ken Yoshida : Phase Transfer Mechanism of TiO2 nanoparticles by NMR diffusometry, Chemeca2013, (巻), (号), (頁), Brisbane, Sep. 2013.

22. Mikito Yasuzawa, Shinya Sato and Kazuaki Edagawa : Patch type glucose sensor for low-invasive glucose monitoring, 224th ECS Meeting, San Francisco, Oct. 2013.

23. Kazuaki Edagawa and Mikito Yasuzawa : In vivo evaluation of fine needle type glucose sensors implanted in rabbit blood vessel, 224th ECS Meeting, San Francisco, Oct. 2013.

24. Ken-Ichiro Sotowa, Takahiro Togawa, Yuika Shimizu, Masashi Kurashina, Toshihide Horikawa and Jesus Rafael Alcantara Avila : Effect of Mixing Methods on the Precipitation of Basic Copper Acetate, International Conference on Process Engineering and Advanced Materials 2014, Kuala Lumpur, June 2014.

25. Sho Kawakami, Atsushi Mori and Yoshihisa Suzuki : Gravitational Tempering in Colloidal Epitaxy, Proceedings of the JSME/ASME 2014 International Conferenec on Materials and Processing, ICPM2014, (巻), (号), (頁), Detroit, June 2014.

26. Sho Kawakami, Atsushi Mori, Yoshihisa Suzuki, Shuichi Hashimoto, Masanobu Haraguchi and Tsutomu Sawada : Nanostructure for Localized Surface Plasmon Coupled with Photonic Band of Gel-Immobilized Colloidal Photonic Crystal, Proceedings of the JSME/ASME 2014 International Conferenec on Materials and Processing, ICPM2014, (巻), (号), (頁), Detroit, June 2014.

27. Takahiro Togawa, Ken-Ichiro Sotowa, Masashi Kurashina, Toshihide Horikawa and Jesus Rafael Alcantara Avila : Basic Copper Acetate Synthesis using a Microchannel-Assisted Crystallizer, Joint Congress of ACTS-2014 and CGOM11, Nara, June 2014.

28. Masaru Nakahara, Ken Yoshida, Hiroshi Kimura and Yasuhiro Uosaki : Hydrothermal Chemical Reactions in Biomass, IAPWS Annual Meeting 2014, (巻), (号), (頁), Moscow, June 2014.

29. Ken Yoshida : Self-diffusion in supercritical water: NMR and MD studies on dynamics of hydrogen bonds, IAPWS Annual Meeting 2014, (巻), (号), (頁), Moscow, June 2014.

30. Masashi Kurashina, Tatsuki Inoue, Chihiro Tajima and Eiji Kanezaki : Removal of borate by coprecipitation with Mg/Al layered double hydroxide, International Conference on Advanced Materials Development and Performance 2014, Busan, July 2014.

31. Yuki Ogawa, Masashi Kurashina, Eiji Kanezaki and Takashi Yamamoto : Effect of aging method on adsorption and elution of phosphate in Mg/Fe layered double hydroxide, International Conference on Advanced Materials Development and Performance 2014, Busan, July 2014.

32. Mikito Yasuzawa, Taketo Toba, Kentaro Hiura, Jiang Li and Yusuke Fuchiwaki : Preparation of micro-biosensor for continuous glucose monitoring, International Conference on Advanced Materials Development and Performance 2014, Busan, July 2014.

33. Kentaro Hiura, Jiang Li, Yusuke Fuchiwaki and Mikito Yasuzawa : Stabilization of enzyme-immobilized film prepared using electrodeposition procedure, International Conference on Advanced Materials Development and Performance 2014, Busan, July 2014.

34. Jiang Li, Daichi Oyama, Kentaro Hiura, Yusuke Fuchiwaki and Mikito Yasuzawa : Preparation and evaluation of a fine tapered needle type glucose sensor, International Conference on Advanced Materials Development and Performance 2014, Busan, July 2014.

35. Yoshinori Otsuka, Yusuke Tanatsugu, Shinsuke Nakanishi, Yusuke Fuchiwaki and Mikito Yasuzawa : Preparation of hydrophobic thin films using perhydropolysilazane, International Conference on Advanced Materials Development and Performance 2014, Busan, July 2014.

36. Shin Ueoka, Keisuke Kimura, Lena Karlsena, Tomoki Yabutani, Mikito Yasuzawa and Kanemi Abe : Removal of cesium ions using prussian blue and magnetic flocculant, International Conference on Advanced Materials Development and Performance 2014, Busan, July 2014.

37. Yoshihisa Suzuki, Masayuki Tsukamoto, Takahisa Fujiwara and Yuta Uehara : High pressure crystallization and crystallography of glucose isomerase, 23rd Congress and General Assembly of the International Union of Crystallography (IUCr2014), Montreal, Aug. 2014.

38. Naoto YOSHIKAWA, Shinya SATO, Takuya HENMI, Tomomi SATO, Genki HAYAKAWA, Masamitsu IIYAMA and Hitoshi Mizuguchi : A dual-electrode system fabricated using track-etched microporous membrane electrodes preared by wet plating, The Michinoku International Symposium on Analytical Science 2014, Sendai, Aug. 2014.

39. Ken Yoshida, Hiroshi Kimura, Masaki Hirayama, Yasuhiro Uosaki and Masaru Nakahara : Hydrothermal Cleavage of Glycosidic Bonds in Biomass for Valuable Chemicals and Fuels, The 15th IUMRS-International Conference in Asia, (巻), (号), (頁), Fukuoka, Aug. 2014.

40. Ayumi Kimura, Tomoki Yabutani and Toshio Takayanagi : Inhibitor Assay of Xanthine Oxidase by Photometric Flow Injection Analysis with Bindschedler's Green Leuco Base, RSC Tokyo International Conference, JASIS Conference, Chiba, Sep. 2014.

41. Hitoshi Mizuguchi : An Electrochemical Flow Cell Fabricated Using Track-Etched Microporous Membrane Electrodes and Its Applications in Flow Analysis, RSC Tokyo International Conference 2014, Chiba, Sep. 2014.

42. N YOSHIKAWA, Shinya SATO, T HENMI, Tomomi SATO, Genki HAYAKAWA, Masamitsu IIYAMA and Hitoshi Mizuguchi : Characterization of Track-Etched Microporous Membrane Electrodes Fabricated by Wet Plating, RSC Tokyo International Conference 2014,, Chiba, Sep. 2014.

43. Mikito Yasuzawa, Jiang Li, Kentaro Hiura, Kazuaki Edagawa and Yusuke Fuchiwaki : Development of Minimally Invasive Biosensor for Continuous Glucose Monitoring, 2014 ECS and SMEQ Joint International Meeting, Cancun (Mexico), Oct. 2014.

44. Kentaro Hiura, Shinya Furukawa, Yusuke Fuchiwaki and Mikito Yasuzawa : Preparation of Glucose Oxidase Immobilized Electrode Using Electrodeposition Procedure and Its Glucose Sensor Properties, 2014 ECS and SMEQ Joint International Meeting, Cancun (Mexico), Oct. 2014.

45. Keiji Minagawa, Mikito Yasuzawa, Yukihiro Arakawa, Yasushi Imada and Shingo Fujita : Attractive Materials for Engineering Chemistry Education Performed under High School/University/Graduate School Partnership, Proceedings of Asian Conference on Engineering Education 2014 (ACEE2014), Kumamoto, Oct. 2014.

46. Mikito Yasuzawa and Shinya Furukawa : Immobilization of enzyme using electrodeposition technique for biosensor application, NANOCON014, Pune, Oct. 2014.

47. Mikito Yasuzawa : Patch type glucose sensor for low-invasive glucose monitoring, India Japan Workshop on ``Nanotechnology: Synthesis & Sensing Applications'', Pune, Oct. 2014.

48. Hitoshi Mizuguchi, Naoto YOSHIKAWA, Kentaro NUMATA, Shinya SATO, Takuya HENMI, Tomoki SATO, Genki HAYAKAWA and Masamitsu IIYAMA : Electrochemical determination of arsenite using a track-etched microporous membrane electrode in a flow system, 19th International Conference on Flow Injection Analysis (19th ICFIA), Fukuoka, Dec. 2014.

49. Natsumi Shimakami, Tomoki Yabutani and Toshio Takayanagi : Determination of Acid Dissociation Constant of Haloperidol under Photo-degraded Conditions through the Measurement of Electrophoretic Mobility by Capillary Zone Electrophoresis, 14th Asia-Pacific International Symposium on Microscale Separations and Analysis, Kyoto, Dec. 2014.

50. Toshio Takayanagi, Yuki Tomiyama, Masaki Morimoto and Tomoki Yabutani : Micellar Electrokinetic Chromatography of Graphenes with Polymer Additive, 14th Asia-Pacific International Symposium on Microscale Separations and Analysis, Kyoto, Dec. 2014.

51. Toru Takahashi, Akihiro Hosono, Toshio Takayanagi and Nobuhiko Iki : Kinetic Analysis of Acidic and Basic Hydrolysis of Tetrabromophenolphthalein Ethyl Ester by Zone-passing Mode Capillary Electrophoretic Reactor, 14th Asia-Pacific International Symposium on Microscale Separations and Analysis, Kyoto, Dec. 2014.

52. Mikito Yasuzawa : Fabrication of glucose oxidase immobilized electrode for in vivo glucose monitoring, Pre-symposium Indo-Japanese Workshop on Sensing Mechanisms, Materials & Applications, Pune, March 2015.

53. Mikito Yasuzawa and Kazuaki Edagawa : In Vivo glucose measurement using fine needle type amperometric glucose sensor, 227th ECS Meeting, Chicago, May 2015.

54. Ken Yoshida : Recent research trends in the conversion of carbohydrate biomass into value-added compounds in aqueous solutions, IAPWS Annual Meeting 2015, (巻), (号), (頁), Stockholm, June 2015.

55. Yusuke Tanatsugu, Chia-Chi Yu, Jinn Chu and Mikito Yasuzawa : Metallic glass coating for non-sticky medical needles, 13th International Symposium on Sputtering & Plasma Processes (ISSP 2015), Kyoto, July 2015.

56. Keiji Minagawa, Mikito Yasuzawa, Yukihiro Arakawa, Yasushi Imada and Shingo Fujita : Design of Effective Chemistry Laboratory Class Based on Partnership among High School, University and Graduate School, Asia-Pacific Conference on Engineering & Applied Sciences (APCEAS2015), Osaka, Aug. 2015.

57. AlexanderE.S. VanDriessche, Mike Sleutel, James Lutsko, Dominique Maes, Katsuo Tsukamoto, Yoshihisa Suzuki and Izumi Yoshizaki : New Insights on Impurity Effects During Crystal Growth Under Various Gravity Conditions, The Joint Conference of 6th International Symposium on Phshycs in Space & 10th Inerntional Conference on Two-Phase System for Space and Ground Applications, (巻), (号), (頁), Kyoto, Sep. 2015.

58. Atsushi Mori, Yoshihisa Suzuki and Masahide Sato : Some Details of Gravitational Tempering in Colloidal Epitaxy Using Hard-Sphre Model, The Joint Conference of 6th International Symposium on Physics in Space & 10th International Conference on Two-Phase System for Space and Ground Applications, (巻), (号), p.17, Kyoto, Sep. 2015.

59. Masahide Sato, Mamoru Fujine, Hiroyasu Katsuno and Yoshihisa Suzuki : Effect of Container Shape and Force Direction on Crystallization of Brownian Particles in Sedimentation, The Joint Conference of 6th International Symposium on Phshycs in Space & 10th Inerntional Conference on Two-Phase System for Space and Ground Applications, (巻), (号), (頁), Kyoto, Sep. 2015.

60. Haruhiko Koizumi, Masaru Tachibana, Izumi Yoshizaki, Seijiro Fukuyama, Katsuo Tsukamoto, Yoshihisa Suzuki, Satoshi Uda and Kenichi Kojima : Dislocations in High-quality Glucose Isomerase Crystals Grown from Seed Crystals, The Joint Conference of 6th International Symposium on Phshycs in Space & 10th Inerntional Conference on Two-Phase System for Space and Ground Applications, (巻), (号), (頁), Kyoto, Sep. 2015.

61. Yoshihisa Suzuki, Katsuo Tsukamoto, Takahisa Fujiwara, Tomohiro Shiomoto, Daido Nakahashi, Izumi Yoshizaki, Seijiro Fukuyama, Masaru Tachibana, Haruhiko Koizumi, Shin-ichiro Yanagiya, Yasutomo Arai and Makoto Natuisaka : Recent Advances on the Ground-Based Experiments of Protein Crystallization after the NanoStep Project, The Joint Conference of 6th International Symposium on Phshycs in Space & 10th Inerntional Conference on Two-Phase System for Space and Ground Applications, (巻), (号), (頁), Kyoto, Sep. 2015.

62. Mikito Yasuzawa, Jiang Li, Masahiro Uchimaru, Yusuke Isoai and Yusuke Fuchiwaki : Fabrication of low-invasive type biosensor for continuous glucose monitoring, The 66th Annual Meeting of the International Society of Electrochemistry, Taipei, Oct. 2015.

63. Jiang Li, Kentaro Hiura, Mikito Yasuzawa and Yusuke Fuchiwaki : Fabrication of low-invasive patch glucose sensors, 228th ECS Meeting, Phoenix, Oct. 2015.

64. Mikito Yasuzawa, Yuya Omura, Kentaro Hiura, Jiang Li, Yusuke Fuchiwaki and Masato Tanaka : Preparation of glucose oxidase-immobilized electrodes using cellulose aqueous solution, 228th ECS Meeting, Phoenix, Oct. 2015.

65. Toshio Takayanagi : Determination of acid dissociation constants of phenolphthalein and its derivatives under degradation, PACIFICHEM 2015, Hawaii, USA, Dec. 2015.

66. Toshio Takayanagi, Ayumi Kimura, Keisuke Matsumoto and Tomoki Yabutani : Spectrophotometric flow injection analyses for the inhibitory assay of xanthine oxidase and the assay of oxidant scavenging capacity, PACIFICHEM 2015, Hawaii, USA, Dec. 2015.

67. Naoto YOSHIKAWA, Shinya SATO, Tomomi SATO, Genki HAYAKAWA, Masamitsu IIYAMA and Hitoshi Mizuguchi : Electrochemical flow-through cell fabricated with nanohole shaped gold electrode, 2015 The International Chemical Congress of Pacific Basin Societies(Pacificchem 2015), Honolulu, Dec. 2015.

68. Hitoshi Mizuguchi : Electrochemical flow-through cell fabricated with track-etched microporous membrane electrodes and its applications in flow analysis, 2015 The International Chemical Congress of Pacific Basin Societies(Pacifichem 2015), Honolulu, Dec. 2015.

69. Toshio Takayanagi, Masaki Morimoto, Yuki Tomiyama and Tomoki Yabutani : Micellar electrokinetic chromatography of graphenes, PACIFICHEM 2015, Hawaii, USA, Dec. 2015.

70. Mikito Yasuzawa : Cellulose nanofiber for enzyme-immobilization, International Conference on Functional Materials and Microwaves (ICFMM-2015), Aurangabad, Dec. 2015.

71. Mikito Yasuzawa, Jiang Li and Kazuaki Edagawa : Fabrication of amperometric enzyme sensor for in vivo glucose monitoring, 2nd International Forum on Advanced Technologies, Tokushima, March 2016.

72. Yusuke Tanatsugu, Mikito Yasuzawa, Chia-Chi Yu and Jinn Chu : Evaluation of thin film metallic glass as a biomaterial, 2nd International Forum on Advanced Technologies, Tokushima, March 2016.

73. Shin Ueoka, Mikito Yasuzawa, Tomoki Yabutani and Kanemi Abe : Removal of cesium ions using magnetic flocculant, 2nd International Forum on Advanced Technologies, Tokushima, March 2016.

74. Yoshinori Otsuka, Yusuke Tanatsugu, Shinsuke Nakanishi, Mikito Yasuzawa and Yusuke Fuchiwaki : Functional surface modification using perhydropolysilazane, 2nd International Forum on Advanced Technologies, Tokushima, March 2016.

【特許・実用新案】

II.4.3 生命システム工学

微生物や動物細胞等の生命システムの基礎研究に根ざした有用な生理活性物質， 医療素材，バイオ素材などの開発. バイオマスからのクリーンエネルギー創成 技術の開発. 生体反応を利用した環境浄化の研究.

II.4.3.1 教員組織

(1) 氏名，(2) メールアドレス，(3) 職名・学位，(4) 専門分野，(5) 所属学会（役職名），(6) 社会活動（役職名），(7) 主要研究テーマ，(8) キーワード，(9) 共同研究可能テーマ

(1) 長宗 秀明, Hideaki Nagamune, (2) ņāġāmūņė (@) bīō ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 教授・医学博士, (4) 微生物学, 免疫学, (5) 日本生化学会 (評議員)・日本細菌学会 (中四国支部評議員)・日本薬学会・日本臨床微生物学会・アメリカ微生物学会・アメリカ微生物学会・日本生化学会 日本生化学会 中国・四国支部 (評議員)・日本細菌学会 ("Microbiology and Immunology"副編集長)・日本細菌学会 (評議員), (6) , (7) 連鎖球菌毒素の構造活性相関と病原性の解析, ガン免疫療法や細胞性医薬品の開発への細菌毒素の応用, 生体膜への作用により免疫賦活作用を示す物質に関する研究, (8) 細菌毒素, 連鎖球菌, 免疫療法, 免疫賦活剤, (9) 連鎖球菌の病原因子, 微生物毒素を用いたバイオツールの開発, 免疫学的分析法の開発

(1) 中村 嘉利, Yoshitoshi Nakamura, (2) yņākāmū (@) bīō ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 教授・工学博士, (4) 生物反応工学, バイオマス変換工学, 環境生物工学, (5) 日本環境化学会・日本生物工学会・社団法人 化学工学会・植物工場学会・環境科学会・日本動物細胞工学会・日本木材学会, (6) 三好市地域新エネルギービジョン策定委員会 (委員長 (2007年9月∼2008年2月))・三好市バイオマスタウン策定委員会 (委員長(2008年9月∼2009年2月))・中国四国バイオマス発見活用協議会, (7) 生体触媒を用いた有用性物質の高効率生産プロセスの開発，バイオマスの総合的有効利用法の構築，汚染環境のバイオレメディエーション, (8) バイオプロセス, バイオマス, 遺伝子組み換え, バイオリアクター, 白色腐朽菌, (9) バイオマスの総合的有効利用

(1) 友安 俊文, Toshifumi Tomoyasu, (2) tōmōyāśū (@) bīō ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 准教授・博士(医学), (4) 病原微生物学, 蛋白質工学, (5) 日本細菌学会 (評議員)・日本分子生物学会・日本生化学会・徳島生物学会・アメリカ微生物学会・日本細菌学会 (中国四国支部 評議員)・日本細菌学会 (中国四国支部 評議員)・日本細菌学会 (中国四国支部 評議員)・日本細菌学会 (評議員), (6) , (7) 連鎖球菌の病原性発現機構, 分子シャペロンの機能に関する研究, (8) 連鎖球菌, 細胞溶解毒素, インターメディリシン, コレステロール, 分子シャペロン, 熱ショック, (9) 分子シャペロンを用いた蛋白質安定化剤の開発

(1) 間世田 英明, Hideaki Maseda, (2) māśėđā (@) bīō ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 准教授・博士(農学), (4) 病原微生物学, 微生物学, 分子生物学, 生化学, (5) 日本細菌学会, (6) , (7) 生理活性物質に対する微生物の応答に関する研究, 病原性微生物の制御に関する研究, (8) 緑膿菌, 多剤耐性, 抗生物質, クォーラムセンシング, カテキン, ミクロシスティン, (9) 微生物言語(Quorum-sensing)を利用した病原性微生物制御剤の開発, 生理活性物質に対する微生物応答を利用した環境汚染物質の分解と評価系の開発

(1) 佐々木 千鶴, Chizuru Sasaki, (2) ċśāśākī (@) bīō ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 講師・博士(工学), (4) バイオマス変換工学, (5) 日本木材学会・社団法人 日本化学会・社団法人 高分子学会, (6) とくしま環境県民会議ストップ温暖化部会(カーボン・オフセット推進検討会)・とくしま環境県民会議新・省エネルギー対策検討会・とくしま環境県民会議ストップ温暖化部会(カーボンオフセット推進検討会), (7) 木質系・草本系バイオマスの総合的有効利用法に関する研究, (8) 木質系・草本系バイオマス, 微生物変換, (9) 未利用バイオマスの有用物質への変換

(1) 浅田 元子, Chikako Asada, (2) āśāđā (@) bīō ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 講師(学位名称), (4) (@.field), (5) , (6) , (7) (@.theme), (8) (@.keyword), (9) (@.collaborate)

(1) 田端 厚之, Atsushi Tabata, (2) ātābātā (@) bīō ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 助教・博士(工学), (4) 微生物学, (5) 日本細菌学会・日本生化学会・日本生物工学会・社団法人 日本農芸化学会・日本防菌防黴学会・徳島生物学会, (6) 徳島大学工業会, (7) 微生物感染と宿主応答メカニズムに関する研究, (8) 細菌毒素, 感染機構, 宿主応答, (9) 細菌感染と宿主応答に関連した研究

(1) 白井 昭博, Akihiro Shirai, (2) śhīŗāī (@) bīō ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 助教・博士(工学), (4) 有機化学, 微生物学, (5) 日本防菌防黴学会 (広報委員)・社団法人 日本化学会・徳島生物学会・公益社団法人 日本生物工学会・アメリカ微生物学会・社団法人 日本化学療法学会, (6) , (7) 環境調和型微生物制御剤の開発に関する研究, (8) (@.keyword), (9) (@.collaborate)

(1) 鬼塚 正義, Masayoshi Onitsuka, (2) ōņītśūkā (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 特任助教(学位名称), (4) 生物化学工学, (5) 日本生物工学会・日本生物物理学会・日本生物工学会, (6) , (7) 蛋白質医薬品生産, 蛋白質生産, 蛋白質科学, (8) 抗体凝集, 細胞株構築, 培養工学, CHO細胞, (9) 抗体(蛋白質)生産

(1) 山野 範子, Noriko Yamano, (2) yāmāņōŗī (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 特任助教・博士(理学), (4) 分子細胞生物学, 生物化学工学, (5) 日本分子生物学会・日本薬理学会・(@.academicsociety) (日本動物細胞工学会(JAACT))・日本技術士会・日本生物工学会, (6) , (7) (@.theme), (8) (@.keyword), (9) (@.collaborate)

II.4.3.2 研究業績

【著　　書】

1. 中村 嘉利, 佐々木 千鶴 : リグニン利用の最新動向, 第4章, 2 水蒸気爆砕法によるリグニンからの化学物質, (発行所), (都市), 2013年7月.

2. 大政 健史, 荻野 千秋, 中島田 豊, 仁宮 一章, 滝口 昇 : 基礎から学ぶ生物化学工学演習, 株式会社 コロナ社, 東京, 2013年9月.

3. 大政 健史 : 8.6.2染色体工学, 丸善出版, (都市), 2014年1月.

4. 鬼塚 正義, 大政 健史 : 第2節[7]細胞培養過程における抗体凝集抑制―ケミカルシャペロン:トレハロースの閉胸―, 情報技術協会, (都市), 2014年4月.

5. 友安 俊文 : 病原性微生物の取扱い, 株式会社エヌ·ティー·エス, (都市), 2014年6月.

6. 日本微生物生態学会 編集, 間世田 英明 : 環境と微生物の辞典, --- 細胞集団の多様性 ---, 朝倉書店, 東京, 2014年7月.

7. 鬼塚 正義, 大政 健史 : 第3編 細胞構築・培地設計 第4章ケミカルシャペロンを用いた蛋白質凝集防止培地の開発, 株式会社シーエムシー出版, (都市), 2015年3月.

【学術論文】

1. Uwate Maki, Ichise Yu-ki, Akihiro Shirai, Takeshi Omasa, Nakae Taiji and Hideaki Maseda : Two routes of MexS-MexT-mediated regulation of MexEF-OprN and MexAB-OprM efflux pump expression in Pseudomonas aeruginosa, Microbiology and Immunology, Vol.57, No.4, pp.263-272, 2013.

2. Lee Ho Kyoung, Masayoshi Onitsuka, Kohsuke Honda, Hisao Ohtake and Takeshi Omasa : Rapid construction of transgene-amplified CHO cell lines by cell cycle checkpoint engineering, Applied Microbiology and Biotechnology, Vol.97, No.13, pp.5731-5741, 2013.

3. Chizuru Sasaki, Mio Wanaka, Hitoshi Takagi, Satoshi Tamura, Chikako Asada and Yoshitoshi Nakamura : Evaluation of epoxy resins synthesized from steam-exploded bamboo lignin, Industrial Crops and Products, Vol.43, pp.757-761, 2013.

4. Hideaki Maseda, Hisaharu Kusaka, Makoto Yamane, Toshiaki Isaka, Kazuhiko Tsutsumi and Shinichi Tebayashi : Endophytic bacterial diversity in Moso bamboo (Phyllostachys edulis) canes by 16S rDNA sequence analysis, Journal of Bioindustrial Science, Vol.2, No.1, pp.8-11, 2013.

5. Akihiro Shirai, Yasuko Fumoto, Tomoaki Shouno, Hideaki Maseda and Takeshi Omasa : Synthesis and biological activity of thiazolyl-acetic acid derivatives as possible antimicrobial agents, Biocontrol Science, Vol.18, No.2, pp.59-73, 2013.

6. Ahmad Haredy, Nobuyuki Takenaka, Hiroshi Yamada, Yoshihiro Sakoda, Masatoshi Okamatsu, Naoki Yamamoto, Takeshi Omasa, Hisao Ohtake, Yasuko Mori, Hiroshi Kida, Koichi Yamanishi and Shigefumi Okamoto : An MDCK cell culture-derived formalin-inactivated influenza whole virion vaccine from an influenza virus library conferred cross-protective immunity by intranasal administration in mice, Clinical and Vaccine Immunology : CVI, Vol.20, No.7, pp.998-1007, 2013.

7. Atsushi Tabata, Yukimasa Ohkubo, Masato Tamura, Toshifumi Tomoyasu, Kazuto Ohkura and Hideaki Nagamune : Construction of an improved drug delivery system tool with enhanced versatility in cell-targeting., Anticancer Research, Vol.33, No.7, pp.2905-2910, 2013.

8. Kawaguchi Yuki, Atsushi Tabata, Hideaki Nagamune and Kazuto Ohkura : Profiles of ILY, VLY and Sm-hPAF interaction with human CD59, Anticancer Research, Vol.33, No.7, pp.2901-2904, 2013.

9. 川野 裕介, 大山 俊幸, 高橋 昭雄, 中村 嘉利 : 水蒸気爆砕リグニンを利用したエポキシ樹脂の合成とバイオマス由来エポキシ樹脂硬化物の作製, ネットワークポリマー, Vol.34, No.2, 77-84頁, 2013年.

10. Yuko Noda, Chikako Asada, Chizuru Sasaki, Saki Hashimoto and Yoshitoshi Nakamura : Extraction method for increasing antioxidant activity of raw garlic using steam explosion, Biochemical Engineering Journal, Vol.73, pp.1-4, 2013.

11. Toshifumi Tomoyasu, Hidenori Imaki, Sachiko Masuda, Ayumi Okamoto, HyeJin Kim, Richard Waite, Robert Whiley, Ken Kikuchi, Keiichi Hiramatsu, Atsushi Tabata and Hideaki Nagamune : LacR mutations are frequently observed in Streptococcus intermedius and are responsible for increased intermedilysin production and virulence., Infection and Immunity, Vol.81, No.9, pp.3276-3286, 2013.

12. Yoshiki Nakashima and Tatsuji Haneji : Stimulation of osteoclast formation by RANKL requires interferon regulatory factor-4 and is inhibited by simvastatin in a mouse model of bone loss, PLoS ONE, Vol.8, No.9, p.e72033, 2013.

13. Tomohiro Inaba, Yuta Tokumoto, Yusuke Miyazaki, Naoyuki Inoue, Hideaki Maseda, Toshiaki Nakajima-Kambe, Hiroo Uchiyama and Nobuhiko Nomura : Analysis of genes for succinoyl trehalose lipid production and increasing production in Rhodococcus sp. strain SD-74., Applied and Environmental Microbiology, Vol.79, No.22, pp.7082-7090, 2013.

14. Di Yang, Hirohiko Okamura, Yoshiki Nakashima and Tatsuji Haneji : Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and Osterix, The Journal of Biological Chemistry, Vol.288, No.47, pp.33530-33541, 2013.

15. KyoungHo Lee, Tomomi Tsutsui, Kohsuke Honda, Ryutaro Asano, Izumi Kumagai, Hisao Ohtake and Takeshi Omasa : Generation of high-producing cell lines by overexpression of cell division cycle 25 homolog A in Chinese hamster ovary cells, Journal of Bioscience and Bioengineering, Vol.116, No.6, pp.754-760, 2013.

16. Ahmad M Haredy, Akitoshi Nishizawa, Kohsuke Honda, Tomoshi Ohya, Hisao Ohtake and Takeshi Omasa : Improved antibody production in Chinese hamster ovary cells by ATF4 overexpression, Cytotechnology, Vol.65, No.6, pp.993-1002, 2013.

17. KyoungHo Lee, Tomomi Tsutsui, Kohsuke Honda, Hisao Ohtake and Takeshi Omasa : Overexpression of mutant cell division cycle 25 homolog B (CDC25B) enhances the efficiency of selection in Chinese hamster ovary cells, Cytotechnology, Vol.65, No.6, pp.1017-1026, 2013.

18. Akihiro Shirai, Toshiyuki Endo, Hideaki Maseda and Takeshi Omasa : Synthesis of thiazole derivatives and evaluation of their antiamoebic activity and cytotoxicity, Biocontrol Science, Vol.18, No.4, pp.183-191, 2013.

19. Naotaka Kishimoto, Yoshihiro Momota, Yoshiya Hashimoto, Shinichi Tatsumi, Kayoko Ando, Takeshi Omasa and Junichiro Kotani : The osteoblastic differentiation ability of human dedifferentiated fat cells is higher than that of adipose stem cells from the buccal fat pad, Clinical Oral Investigations, 2013.

20. Akihiro Shirai, Mutsumi Aihara, Akira Takahashi, Hideaki Maseda and Takeshi Omasa : Synergistic antimicrobial activity based on the combined use of a gemini-quaternary ammonium compound and ultraviolet A light, Journal of Photochemistry and Photobiology B: Biology, Vol.130, (号), pp.226-233, 2014.

21. Keisuke Ishizawa, Yuki Izawa-Ishizawa, Noriko Yamano, Maki Urushihara, Takumi Sakurada, Masaki Imanishi, Shoko Fujii, Asami Nuno, Rihito Miyamoto, Yoshitaka Kihira, Yasumasa Ikeda, Shoji Kagami, Hiroyuki Kobori, Koichiro Tsuchiya and Toshiaki Tamaki : Nitrosonifedipine ameliorates the progression of type 2 diabetic nephropathy by exerting antioxidative effects, PLoS ONE, Vol.9, No.1, p.e86335, 2014.

22. Atsushi Tabata, Kazuto Ohkura, Ohkubo Yukimasa, Toshifumi Tomoyasu, Ohkuni Hisashi, Whiley A. Robert and Hideaki Nagamune : The diversity of receptor recognition in cholesterol-dependent cytolysins, Microbiology and Immunology, Vol.58, No.3, pp.155-171, 2014.

23. Yoshitaka Kihira, Mariko Miyake, Manami Hirata, Yoji Hoshina, Kana Kato, Hitoshi Shirakawa, Hiroshi Sakaue, Noriko Yamano, Yuki Izawa-Ishizawa, Keisuke Ishizawa, Yasumasa Ikeda, Koichiro Tsuchiya, Toshiaki Tamaki and Shuhei Tomita : Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation., PLoS ONE, Vol.9, No.4, p.e93856, 2014.

24. Ga-Hyun Joe, Midori Andoh, Mikako Nomura, Hitoshi Iwaya, Jae-Sung Lee, Hidehisa Shimizu, Youhei Tsuji, Hideaki Maseda, Hitoshi Miyazaki, Hiroshi Hara and Satoshi Ishizuka : Acyl-homoserine lactones suppresses IEC-6 cell proliferation and increase permeability of isolated rat colon., Bioscience, Biotechnology, and Biochemistry, Vol.78, No.3, pp.462-465, 2014.

25. Masayoshi Onitsuka, Akira Kawaguchi, Ryutaro Asano, Izumi Kumagai, Kohsuke Honda, Hisao Ohtake and Takeshi Omasa : Glycosylation analysis of an aggregated antibody produced by Chinese hamster ovary cells in bioreactor culture, Journal of Bioscience and Bioengineering, Vol.117, No.5, pp.639-644, 2014.

26. Masayoshi Onitsuka, Miki Tatsuzawa, Ryutaro Asano, Izumi Kumagai, Akihiro Shirai, Hideaki Maseda and Takeshi Omasa : Trehalose suppresses antibody aggregation during the culture of Chinese hamster ovary cells, Journal of Bioscience and Bioengineering, Vol.117, No.5, pp.632-638, 2014.

27. Chizuru Sasaki, Ryosuke Okumura, Chikako Asada and Yoshitoshi Nakamura : Steam explosion treatment for ethanol production from pear tree prunings by simultaneous saccharification and fermentation, Bioscience, Biotechnology, and Biochemistry, Vol.78, No.1, pp.160-166, 2014.

28. Atsushi Tabata, Sato Yuji, Maya Kentaro, Nakano Kota, Kikuchi Ken, Whiley A. Robert, Kazuto Ohkura, Toshifumi Tomoyasu and Hideaki Nagamune : A streptolysin S homologue is essential for beta-haemolytic Streptococcus constellatus subsp. constellatus cytotoxicit, Microbiology, Vol.160, No.5, pp.980-991, 2014.

29. Ryoko Taguchi, Shinya Tanaka, Ga-Hyun Joe, Hideaki Maseda, Nobuhiko Nomura, Junji Ohnishi, Satoshi Ishizuka, Hidehisa Shimizu and Hitoshi Miyazaki : Mucin 3 is involved in intestinal epithelial cell apoptosis via N-(3-oxododecanoyl)-L-homoserine lactone-induced suppression of Akt phosphorylation., American Journal of Physiology, Cell Physiology, Vol.307, No.2, pp.C162-8, 2014.

30. Masaki Imanishi, Shuhei Tomita, Keisuke Ishizawa, Yoshitaka Kihira, Masaki Ueno, Yuki Izawa-Ishizawa, Yasumasa Ikeda, Noriko Yamano, Koichiro Tsuchiya and Toshiaki Tamaki : Smooth muscle cell specific Hif-1 deficiency suppresses angiotensin II-induced vascular remodeling in mice, Cardiovascular Research, Vol.102, No.3, pp.460-468, 2014.

31. Chizuru Sasaki, Masaki Ichitani, Ko-Ki Kunimoto, Chikako Asada and Yoshitoshi Nakamura : Extraction of arbutin and its comparative content in branches, leaves, stems, and fruits of Japanese pear Pyrus pyrifolia cv. Kousui, Bioscience, Biotechnology, and Biochemistry, Vol.78, No.5, pp.874-877, 2014.

32. Imaki Hidenori, Toshifumi Tomoyasu, Yamamoto Naoki, Taue Chiharu, Masuda Sachiko, Takao Ayuko, Maeda Nobuko, Atsushi Tabata, Whiley A. Robert and Hideaki Nagamune : Identification and Characterization of a Novel Secreted Glycosidase with Multiple Glycosidase Activities in Streptococcus intermedius, Journal of Bacteriology, Vol.196, No.15, pp.2817-2826, 2014.

33. Atsushi Tabata, Anyoji Natsuki, Ohkubo Takamasa, Toshifumi Tomoyasu and Hideaki Nagamune : Investigation on the Reaction Conditions of Staphylococcus aureus Sortase A for Creating Surface-modified Liposomes as a Drug-delivery System Tool, Anticancer Research, Vol.34, No.8, pp.4521-4527, 2014.

34. Kawaguchi Yuki, Atsushi Tabata, Hideaki Nagamune and Kazuto Ohkura : Molecular Analysis of Streptococcus anginosus-derived SagA Peptides, Anticancer Research, Vol.34, No.8, pp.4627-4631, 2014.

35. Tohru Kimura, Yoshiaki Kaga, Hiroshi Ohta, Mika Odamoto, Yoichi Sekita, Kunpeng Li, Noriko Yamano, Keita Fujiwara, Ayako Isotani, Norihiko Sasaki, Masashi Toyoda, Katsuhiko Hayashi, Masaru Okabe, Takashi Shinohara, Mitinori Saitou and Toru Nakano : Induction of primordial germ cell-like cells from mouse embryonic stem cells by ERK signal inhibition, Stem Cells, Vol.32, No.10, pp.2668-2678, 2014.

36. Ryutaro Asano, Ippei Shimomura, Shota Konno, Akiko Ito, Yosuke Masakari, Ryota Orimo, Shintaro Taki, Kyoko Arai, Hiromi Ogata, Mai Okada, Shozo Furumoto, Masayoshi Onitsuka, Takeshi Omasa, Hiroki Hayashi, Yu Katayose, Michiaki Unno, Toshio Kudo, Mitsuo Umetsu and Izumi Kumagai : Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics., mAbs, Vol.6, No.5, pp.1243-1254, 2014.

37. Chizuru Sasaki, Yohei Kushiki, Chikako Asada and Yoshitoshi Nakamura : Acetone-butanol-ethanol production by separate hydrolysis and fermentation (SHF) and simultaneous saccharification and fermentation (SSF) methods using acorns and wood chips of Quercus acutissima as a carbon source, Industrial Crops and Products, Vol.62, (号), pp.286-292, 2014.

38. Masayoshi Onitsuka and Takeshi Omasa : Rapid evaluation of N-glycosylation status of antibodies with chemiluminescent lectin-binding assay., Journal of Bioscience and Bioengineering, Vol.120, No.1, pp.107-110, 2014.

39. Kim Hyejin, Atsushi Tabata, Toshifumi Tomoyasu, Ueno Tomomi, Uchiyama Shigeto, Keizo Yuasa, Akihiko Tsuji and Hideaki Nagamune : Estrogen stimuli promote osteoblastic differentiation via the subtilisin-like proprotein convertase PACE4 in MC3T3-E1 cells., Journal of Bone and Mineral Metabolism, Vol.33, No.1, pp.30-39, 2015.

40. Chikako Asada, Chizuru Sasaki, Tomoki Takamatsu and Yoshitoshi Nakamura : Conversion of steam-exploded cedar into ethanol using simultaneous saccharification, fermentation and detoxification process, Bioresource Technology, Vol.176, (号), pp.203-209, 2015.

41. Chikako Asada, Sunita Basnet, Masaya Otsuka, Chizuru Sasaki and Yoshitoshi Nakamura : Epoxy resin synthesis using low molecular weight lignin separated from various lignocellulosic materials, International Journal of Biological Macromolecules, Vol.74, pp.413-419, 2015.

42. Sunita Basnet, Masaya Otsuka, Chizuru Sasaki, Chikako Asada and Yoshitoshi Nakamura : Functionalization of the active ingredients of Japanese green tea (Camellia sinensis) for the synthesis of bio-based epoxy resin, Industrial Crops and Products, Vol.73, pp.63-72, 2015.

43. Akihiro Shirai, Masayoshi Onitsuka, Hideaki Maseda and Takeshi Omasa : Effect of polyphenols on reactive oxygen species production and cell growth of human dermal fibroblasts after irradiation with ultraviolet-A light, Biocontrol Science, Vol.20, No.1, pp.27-33, 2015.

44. Hidehisa Shimizu, Nanako Baba, Takuma Nose, Ryoko Taguchi, Shinya Tanaka, Ga-Hyun Joe, Hideaki Maseda, Nobuhiko Nomura, Masahito Hagio, Ja-Young Lee, Satoru Fukiya, Atsushi Yokota, Satoshi Ishizuka and Hitoshi Miyazaki : Activity of ERK regulates mucin 3 expression and is involved in undifferentiated Caco-2 cell death induced by 3-oxo-C12-homoserine lactone., Bioscience, Biotechnology, and Biochemistry, Vol.16, No.6, pp.1-6, 2015.

45. Noriko Yamano, Yasumasa Ikeda, Minoru Sakama, Yuki Izawa-Ishizawa, Yoshitaka Kihira, Keisuke Ishizawa, Rihito Miyamoto, Shuhei Tomita, Koichiro Tsuchiya and Toshiaki Tamaki : A Long-Term High-Fat Diet Changes Iron Distribution in Body, Increasing Iron Accumulation Specifically in the Mouse Spleen, Journal of Nutritional Science and Vitaminology, Vol.61, No.1, pp.20-27, 2015.

46. Chikako Asada, Chizuru Sasaki, Takeshi Hirano and Yoshitoshi Nakamura : Chemical characteristics and enzymatic saccharification of lignocellulosic biomass treated using high-temperature saturated steam: Comparison of softwood and hardwood, Bioresource Technology, Vol.182, pp.245-250, 2015.

47. Ai Asakawa, Misato Kohara, Chizuru Sasaki, Chikako Asada and Yoshitoshi Nakamura : Comparison of choline acetate ionic liquid pretreatment with variouspretreatments for enhancing the enzymatic saccharification ofsugarcane bagasse, Industrial Crops and Products, Vol.71, pp.147-152, 2015.

48. Shoma Maruyama, Hitoshi Takagi, Yoshitoshi Nakamura, Antonio Norio Nakagaito and Chizuru Sasaki : Influence of alkali treatment on mechanical properties of poly lactic acid bamboo fiber green composites, Advanced Materials Research, Vol.1110, pp.56-59, 2015.

49. Rima Matsuyama, Tomomi Tsutsui, Ho Kyoung Lee, Masayoshi Onitsuka and Takeshi Omasa : Improved gene amplification by cell-cycle engineering combined with the Cre-loxP system in Chinese hamster ovary cells., Journal of Bioscience and Bioengineering, Vol.120, No.6, pp.701-708, 2015.

50. Atsushi Tabata, Ohkubo Yukihisa, Natsuki Anyhoji, Keiko Hojo, Toshifumi Tomoyasu, Youhei Tatematsu, Kazuto Ohkura and Hideaki Nagamune : Development of a Sortase A-mediated Peptide-labeled Liposome Applicable to Drug-delivery Systems, Anticancer Research, Vol.35, No.8, pp.4411-4417, 2015.

51. Akihiro Shirai, Masato Kajiura and Takeshi Omasa : Synergistic photobactericidal activity based on ultraviolet-A irradiation and ferulic acid derivatives, Photochemistry and Photobiology, Vol.91, No.6, pp.1422-1428, 2015.

52. Akihiro Shirai, Masato Kajiura, Kyohei Matsumura and Takeshi Omasa : Improved photobactericidal activity of ultraviolet-A light in combination with isomerizable p-coumaric acid derivatives, Biocontrol Science, Vol.20, No.4, pp.231-238, 2015.

53. Chizuru Sasaki, Yusuke Yoshida, Chikako Asada and Yoshitoshi Nakamura : Total utilization of Japanese pear tree prunings: extraction of arbutin and production of bioethanol, Journal of Material Cycles and Waste Management, Vol.18, No.2, pp.385-392, 2015.

54. Tetsu Tomonari, Shunsaku Takeishi, Tatsuya Taniguchi, Takahiro Tanaka, Hironori Tanaka, Shota Fujimoto, Tetsuo Kimura, Koichi Okamoto, Hiroshi Miyamoto, Naoki Muguruma and Tetsuji Takayama : MRP3 as a novel resistance factor for sorafenib in hepatocellular carcinoma, Oncotarget, Vol.7, No.6, pp.7207-7215, 2016.

55. Bahadur Md Badsha, Hiroyuki Kurata, Masayoshi Onitsuka, Takushi Oga and Takeshi Omasa : Metabolic analysis of antibody producing Chinese hamster ovary cell culture under different stresses conditions., Journal of Bioscience and Bioengineering, (巻), (号), (頁), 2016.

【総説・解説】

1. 大政 健史 : 書評:幹細胞技術の標準化―再生医療への期待, バイオサイエンスとインダストリー, Vol.71, No.3, 298頁, 2013年5月.

2. 中村 嘉利, 佐々木 千鶴, 浅田 元子 : 超高温高圧水蒸気爆砕を用いた未利用植物資源の有効利用, 化学工学会バイオ部会News letter, No.33, 4-7頁, 2013年6月.

3. 大政 健史 : バイオ医薬品生産におけるプロダクションサイエンス, 生物工学会誌, Vol.91, No.9, 507-510頁, 2013年9月.

4. 今西 正樹, 石澤 啓介, 櫻田 巧, 石澤 有紀, 山野 範子, 木平 孝高, 池田 康将, 土屋 浩一郎, 玉置 俊晃 : 酸化ストレス制御を基盤とする新規心腎血管障害治療薬の開発, 薬学雑誌, Vol.134, No.6, 715-719頁, 2014年6月.

【国際会議 Proceedings】

1. Hiroyuki Kagawa, Yoshiaki Okabe, Chizuru Sasaki and Yoshitoshi Nakamura : Correlation berween lignin properties and properties of epoxy resin hardened by cedar lignin, 17th Annual Green Chemistry and Engineering Conference, (巻), (号), (頁), Washington DC, June 2013.

2. Masayoshi Onitsuka, Tatsuzawa Miki, Noda Masahiro, Koguma Ichiro, Akihiro Shirai and Takeshi Omasa : Dynamical analysis of antibody aggregation in the CHO cell culture with thermo responsive protein A (TRPA) column, ESACT Meeting 2013 in Lille, No.A122, p.97, (都市), June 2013.

3. Noda Masahiro, Tatsuzawa Miki, Masayoshi Onitsuka, Akihiro Shirai and Takeshi Omasa : Chemical shaperon suppresses the antibody aggregation in CHO cell culture, ESACT Meeting 2013 in Lille, No.A121, p.97, Lille,France, June 2013.

4. Lee Kyoungho, Honda Kohsuke, Ohtake Hisao and Takeshi Omasa : Rapid onstruction of transgene-amplified COcell lines by cell cycle checkpoint engineering, ESACT Meeting 2013 in Lille, No.O-19, p.31, Lille,France, June 2013.

5. Hiroyuki Kagawa, Yoshiaki Okabe, Chizuru Sasaki and Yoshitoshi Nakamura : Correlation between lignin properties and properties of epoxy resin hardened by cedar lignin, Baekeland 2013, (都市), July 2013.

6. Keisuke Ishizawa, Noriko Yamano, Hiroyuki Kobori, Maki Urushihara, Yuki Izawa-Ishizawa, Yoshitaka Kihira, Yasumasa Ikeda, Koichiro Tsuchiya and Toshiaki Tamaki : Nitrosonifedipine prevents the progression of diabetic nephropathy via attenuating the expression of intrarenal angiotensinogen and oxidative stress, High Blood Pressure Research 2013 Scientific Sessions, (巻), (号), (頁), (都市), Sep. 2013.

7. Tomomi Tsutsui, Ho Kyong Lee, Rina Matsuyama, Masayoshi Onitsuka and Takeshi Omasa : Cell cycle checkpoint engineering: novel construction method of gene-amplified CHO cell line for therapeutic antibody production, The 12th Tunisian-Japanese Symposium on Society, Science and Technology (TJASSST2013), p.14, Tsunisia, Nov. 2013.

8. Takeshi Omasa : Efficient Construction of Transgene-Amplified CHO Cell Lines by Cell Checkpoint Engineering, Pep Talk 2014, Palm Springs, California, USA, Jan. 2014.

9. Uwate Maki, Ichise Yu-ki, Nakae Taiji and Hideaki Maseda : Expression of antibiotic resistance genes by specific nucleotide deletion in Pseudomonas aeruginosa, The 12th Japan-Koria International Symposium on Microbiology 2014, p.88, Tokyo, March 2014.

10. Ichise Yu-ki, Uwate Maki, Nakae Taiji and Hideaki Maseda : Analysis of transient expression of MexEF-OprN efflux pump in Pseudomnas aeruginosa, The 12th Japan-Koria International Symposium on Microbiology 2014, p.90, Tokyo, March 2014.

11. Takeshi Omasa : Analysis of anti -aggregation effect in trehalose-supplemented CHO cell culture, Cell Culture Engineering XIV, (巻), (号), (頁), Quebec City, Canada, May 2014.

12. Uwate Maki, Ichise Yu-ki, Nakae Taiji, Akihiro Shirai and Hideaki Maseda : The mechanism of mexT gene activation in the expression of the mexEF-oprN operon in Pseudomonas aeruginosa, 114th General Meeting, American Society for Microbiology, p.168, Boston, May 2014.

13. Ichise Yu-ki, Uwate Maki, Akihiro Shirai, Nakae Taiji and Hideaki Maseda : Role of MexEF-OprN efflux pump in wild type strain of Pseudomonas aeruginosa, 114th General Meeting, American Society for Microbiology, p.145, Boston, May 2014.

14. Hiroyuki Kagawa, Yoshiaki Okabe, Chizuru Sasaki and Yoshitoshi Nakamura : Properties of epoxy resins hardened by woody lignins obtained by steam explosion, 18th Annual Green Chemistry & Engineering Conference, (都市), June 2014.

15. Shoma Maruyama, Hitoshi Takagi, Yoshitoshi Nakamura, Antonio Norio Nakagaito and Chizuru Sasaki : Influence of alkali treatment on mechanical properties of poly lactic acid bamboo fiber green composites, Program and Abstract Book for 7th International Conference AMDP 2014, p.65, Busan, July 2014.

16. Hiroyuki Kagawa, Yoshiaki Okabe, Chizuru Sasaki and Yoshitoshi Nakamura : Properties of epoxy resins hardened by woody lignins obtained by steam explosion, 5th International IUPAC Conference on Green Chemistry, (巻), (号), (頁), Durban, Aug. 2014.

17. Akihiro Shirai, Matsumura Kyohei, Masayoshi Onitsuka, Hideaki Maseda and Takeshi Omasa : Application of photochromism to the molecular design of antimicrobial agents: synthesis of phenolic derivatives and their bactericidal activity based on a photo-reaction with ultraviolet-A light, III International Conference on Antimicrobial Research, No.T64, p.289, Madrid, Oct. 2014.

18. Noriko Yamano, Mai Takahashi, Toshitaka Kumamoto, Tomoharu Murakami, Jana Frank, Masayoshi Onitsuka and Takeshi Omasa : The effect of chromosome number to antibody production in Chinese Hamster Ovary Cells, The 20th Symposium of Young Asian Biochemical Engineers' Community (YABEC) 2014, (巻), (号), (頁), (都市), Nov. 2014.

19. Jana Frank, Toshitaka Kumamoto, Masayoshi Onitsuka, Noriko Yamano and Takeshi Omasa : Chromosome rearrangements and instability in Chinese hamster ovary cell line, The 20th Symposium of Young Asian Biochemical Engineers' Community (YABEC) 2014, (巻), (号), (頁), (都市), Nov. 2014.

20. Atsushi Tabata, Nakano Kota, Sato Yuji, Maya Kentaro, Ohtani Hiromi, Ohkubo Yukimasa, Kazuto Ohkura, Kikuchi Ken, Whiley A Robert, Toshifumi Tomoyasu and Hideaki Nagamune : STREPTOLYSIN S HOMOLOGUES OF PEPTIDE HEMOLYSIN: NOVEL BETA-HEMOLYTIC FACTORS DISTRIBUTED AMONG BETA-HEMOLYTIC ANGINOSUS GROUP STREPTOCOCCI, XIX Lancefield International Symposium on Streptococci and Streptococcal Diseases, Buenos Aires, Argentina, Nov. 2014.

21. Hideaki Nagamune, Toshifumi Tomoyasu, 今木 英統, 山本 直輝, 田上 千遥, 増田 早智子, 高尾 亞由子, 前田 伸子, Atsushi Tabata and Whiley A. Robert : CHARACTERIZATION OF A NOVEL SECRETED GLYCOSIDASE WITH MULTIPLE GLYCOSIDASE ACTIVITIES, MSGA: A CANDIDATE KEY ENZYME REGULATING GROWTH AND PATHOGENICITY OF STREPTOCOCCUS INTERMEDIUS, XIX Lancefield International Symposium on Streptococci and Streptococcal Diseases, (都市), Nov. 2014.

22. Takao Ayuko, Hideaki Nagamune and Maeda Nobuko : INFLUENCE OF SIGNAL PEPTIDE PHEROMONES ON TRANSFORMATION EFFICIENCY AND BACTERIOCIN PRODUCTION IN STREPTOCOCCUS INTERMEDIUS, Proceeding of International Conference/XIX Lancefield International Symposium on Streptococci and Streptococcal Diseases, (都市), Nov. 2014.

23. Matsuyama Rima, Tsutsui Tomomi, Lee Ho Kyoung, Masayoshi Onitsuka and Takeshi Omasa : Accelerated gene amplification by checkpoint bypass with cell division cycle 25 homolog B (CBC25B), 7th Annual and international meeting of Japanese Association for Animal Cell Technology (JAACT 2014), p.P.74, (都市), Nov. 2014.

24. Kinoshita Yukie, Masayoshi Onitsuka and Takeshi Omasa : Enhanced antibody production by transcription factor NFKBIZ in CHO cells, 27th Annual and international meeting of Japanese Association for Animal Cell Technology (JAACT '14), p.P.75, Kitakyushu, Japan, Nov. 2014.

25. Jana Frank, Kumamoto Toshitaka, Noriko Yamano, Masayoshi Onitsuka and Takeshi Omasa : Function of chromosome fragile sites in engineeiring of Chinese hamster ovary DG44-based cell line, 27th Annual and international meeting of Japanese Association for Animal Cell Technology (JAACT '14), p.P.88, Kitakyushu, Japan, Nov. 2014.

26. Masayoshi Onitsuka, Ide Teruhiko and Takeshi Omasa : Separation of antibody aggregation with FcRI column, 27th Annual and international meeting of Japanese Association for Animal Cell Technology (JAACT '14), p.P.89, Kitakyushu, Japan, Nov. 2014.

27. Masayoshi Onitsuka and Takeshi Omasa : Antibody Aggregation in CHO Cell Culture: Mechanism and Suppression, Symposium 3 ``Advanced Technologies for Next Generation Cell and Cell Culture Engineering'' in 27th Annual and international meeting of Japanese Association for Animal Cell Technology (JAACT 2014), (巻), (号), (頁), (都市), Nov. 2014.

28. Hiroyuki Kagawa, Yoshiaki Okabe, Chizuru Sasaki and Yoshitoshi Nakamura : Heat resistance epoxy resin from woody lignin obtained by steam explosion, The 10th SPSJ International Polymer Conference (IPC2014), (巻), (号), (頁), Tsukuba, Dec. 2014.

29. Hideaki Nagamune, Atsushi Tabata, Yoshitoshi Ogura and Tetsuya Hayashi : Diversity in genome structure showing the genomic dynamism of human-derived Streptococcus mitis, International Symposium on Genome Science 2015: Expanding Frontiers of Genome Science II, (都市), Jan. 2015.

30. Akihiro Suzuki, Masaya Otsuka, Chizuru Sasaki, Chikako Asada and Yoshitoshi Nakamura : Thermo-Mechanical Properties of Plant-Derived Resin, International forum on advanced technologies, (巻), (号), (頁), Toksuhima, March 2015.

31. Takeshi Hirano, Chizuru Sasaki, Chikako Asada and Yoshitoshi Nakamura : High-pressure steam pretreatment for increasing delignification and saccharification of woody biomass, International forum on advanced technologies, (巻), (号), (頁), Toksuhima, March 2015.

32. Sunita Basnet, Masaya Otsuka, Chizuru Sasaki, Chikako Asada and Yoshitoshi Nakamura : Catechin from green tea: a potential candidate for biobased epoxy resin, International forum on advanced technologies, (巻), (号), (頁), Toksuhima, March 2015.

33. Hiroyuki Kagawa, Yoshiaki Okabe, Chizuru Sasaki and Yoshitoshi Nakamura : Epoxy resin and its hardener from woody lignin obtained by steam explosion, IAWPS International Symposium on Wood Science and Technology 2015 (IAWPS 2015), (巻), (号), (頁), Tokyo, March 2015.

34. Toshitaka Kumamoto, Mai Takahashi, Masayoshi Onitsuka and Takeshi Omasa : Analysis of chromosome number and its application to antibody production in Chinese hamster ovary cells., Culture Engineering XIV, Quebec City, Canada, p.P-18, (都市), May 2015.

35. Matsuyama Rima, Tsutsui Tomomi, Lee Ho Kyoung, Masayoshi Onitsuka and Takeshi Omasa : Generation of high-producing cell lines by cell cycle checkpoint engineering in CHO cells., Cell Culture Engineering XIV, Quebec City, Canada, p.P-44, (都市), May 2015.

36. Takeshi Omasa, Masayoshi Onitsuka, Tatsuzawa Miki and Noda Masahiro : Analysis of anti-aggregation effect in trehalose-supplemented CHO cell culture., Cell Culture Engineering XIV, Quebec City, Canada, p.P-142, (都市), May 2015.

37. Noriko Yamano, Toshitaka Kumamoto, Mai Takahashi, Jana Frank, Masayoshi Onitsuka and Takeshi Omasa : Stability difference of each chromosome in Chinese Hamster Ovary cell line, The 24th Meeting of the European Society for Animal Cell Technology (ESACT) 2015, (巻), (号), (頁), (都市), May 2015.

38. YuanShan Lai, Noriko Yamano, Masayoshi Onitsuka and Takeshi Omasa : Increased antibody productivity in Chinese Hamster Ovary cells through induction of chromosomal instability by cell fusion, The 24th Meeting of the European Society for Animal Cell Technology (ESACT) 2015, (巻), (号), (頁), (都市), May 2015.

39. Marina Aga, Noriko Yamano, Toshitaka Kumamoto, Jana Frank, Masayoshi Onitsuka and Takeshi Omasa : Construction of a gene knockout CHO cell line using a simple gene targeting method, The 24th Meeting of the European Society for Animal Cell Technology (ESACT) 2015, (巻), (号), (頁), (都市), May 2015.

40. Tatsuya Masuoka, Takuya Kawakami, T Kiyoshima, Chikako Asada, Yoshitoshi Nakamura, Kenji Teranishi and Naoyuki Shimomura : Effect of Pulsed Discharges on Mycelium Growth of Sparassis Crispa, Proceedings of the 20th IEEE Pulsed Power Conference, pp.67-71, Austin, June 2015.

41. Masashi Yamamoto, Reiko Matsumura, Yoshihiko Hirata and Hideaki Nagamune : Evaluation of biocompatibility of novel and commonly-used antiseptics by cell culture method, Antimicrobial Resistance and Infection Control, Vol.4, No.suppl1, p.38, Geneva, Switzerland, June 2015.

42. Noriko Yamano : Chromosome identification and stability in Chinese Hamster Ovary cells, 6th Annual Cell Culture World Congress 2016, (巻), (号), (頁), (都市), Feb. 2016.

【特許・実用新案】

1. 長宗 秀明 : 二重標識融合PCRイムノクロマトグラフィー, 特願2008-005003 (2008年1月), 特開2009-165371 (2009年7月), 特許第5435687号 (2013年12月).

2. 高麗 寛紀, 白井 昭博 : 抗菌性・抗黴性ケイ酸アルミニウムおよびその製造方法, 特願2010-013162 (2010年1月), 特開2011-148754 (2011年8月), 特許第5542460号 (2014年5月).

3. 白井 昭博, 延嶋浩文 (名) : 抗菌・抗黴性ピリジン化合物，抗菌・抗黴性樹脂組成物，及び樹脂成形品, 特願2015-087255 (2015年4月), (開示), (番号) ((年月日)).

II.4.4 生命情報工学

動植物の生体情報を制御する生理活性ペプチド/タンパク質・の活性化を司るプ ロテアーゼの研究を通じた生活習慣病，癌，骨形成等に関する研究. 癌治療に 利用できる生理活性物質やセンサー物質の分子設計と開発研究.

II.4.4.1 教員組織

(1) 氏名，(2) メールアドレス，(3) 職名・学位，(4) 専門分野，(5) 所属学会（役職名），(6) 社会活動（役職名），(7) 主要研究テーマ，(8) キーワード，(9) 共同研究可能テーマ

(1) 辻 明彦, Akihiko Tsuji, (2) tśūjī ₍.₎ ākīhīkō (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 教授・医学博士, (4) 生化学, 酵素化学, (5) 日本生化学会・日本分子生物学会・日本細胞生物学会・先天代謝異常学会・The American Society for Biochemistry and Molecular Biology・日本蛋白質科学会・日本生物工学会・International Proteolysis Society, (6) , (7) 細胞増殖分化の制御におけるプロプロテインコンベルターゼの役割, 植物プロテアーゼの構造と機能, 動物セルラーゼの構造と応用, (8) プロテアーゼ, プロセシング, 翻訳後修飾, 血清タンパク, 酵素補充療法, (9) 酵素一般

(1) 宇都 義浩, Yoshihiro Uto, (2) ūtō ₍.₎ yōśhīhīŗō (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 教授・博士(情報工学), (4) 生物有機化学, (5) 日本薬学会・日本癌学会・国際癌治療増感研究協会・バイオ治療法研究会 (運営委員)・日本酸化ストレス学会・ビタミンE研究会 (幹事)・日本放射線腫瘍学会, (6) , (7) 低酸素細胞放射線増感剤の開発, フェノール性脂質過酸化阻害剤の開発, (8) スレーディングインターカレータ, 低酸素細胞, 脂質過酸化阻害剤, (9) 分子設計と合成

(1) 湯浅 恵造, Keizo Yuasa, (2) kyūāśā (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 准教授・博士(農学), (4) 生化学, 細胞生物学, (5) 日本生化学会・日本分子生物学会・日本農芸化学会, (6) , (7) 細胞間·細胞内シグナル伝達, (8) タンパク質, プロテアーゼ, キナーゼ, 転写因子, (9) 細胞間·細胞内におけるシグナル伝達の解析

(1) 山田 久嗣, Hisatsugu Yamada, (2) yāmāđā ₍.₎ hīśātśūġū (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 講師・博士(工学), (4) 生物有機化学, ケミカルバイオロジー, (5) 社団法人 日本化学会・日本化学会 生体機能関連化学部会・社団法人 有機合成化学協会 (編集協力委員)・近畿化学協会・光化学協会・日本分子イメージング学会・日本ケミカルバイオロジー学会・アメリカ化学会, (6) , (7) In vivo ケミカルプローブの創製と生体分子イメージングの新手法の開拓, (8) (@.keyword), (9) (@.collaborate)

II.4.4.2 研究業績

【著　　書】

1. Teruyuki Kondo, Kimura Yu, Hisatsugu Yamada and Akio Toshimitsu : Ruthenium-based catalysts for aerobic oxidation of alcohols, RSC Publishing, Cambridge, UK, (month)2014.

2. Teruyuki Kondo, Yu Kimura, Hisatsugu Yamada and Akio Toshimitsu : Magnetic Nanoparticles for Multimodal Bio-imaging, Nova Science Publishers, New York, (month)2014.

3. Takahito Watanabe, Sumihare Noji and Taro Mito : GeneKnockout by Targeted Mutagenesis in a Hemimetabolous Insect, the Two-Spotted Cricket Gryllus bimaculatus, using TALENs. In TALENs: Methods and Protocols (Ralf Kuhn et al. eds.), Springer, New York, (month)2016.

【学術論文】

1. Naoyuki Shimomura, Masataka Nagahama, Kenji Teranishi, Yoshihiro Uto and Hitoshi Hori : Introduction of Embryonic Chick Assay on Experiment Applying Nanosecond Pulse Electric Fields on Solid Tumor, IEEJ Transactions on Fundamentals and Materials, Vol.133, No.4, pp.231-232, 2013.

2. Masahiro Inoue, Kouichi Yasuda, Haruki Uemura, Natsumi Yasaka, Achim Schnaufer, Mihiro Yano, Hiroshi Kido, Daisuke Kohda, Hirofumi Doi, Toshihide Fukuma, Akihiko Tsuji and Nobuo Horikoshi : Trypanosoma brucei 14-3-3I and II proteins predominantly form a heterodimer structure that acts as a potent cell cycle regulator in vivo., The Journal of Biochemistry, Vol.153, No.5, pp.431-439, 2013.

3. Akihiko Tsuji, Keiko Tominaga, Nami Nishiyama and Keizo Yuasa : Comprehensive enzymatic analysis of the cellulolytic system in digestive fluid of the sea hare aplysia kurodai. efficient glucose release from sea lettuce by synergistic action of 45 kDa endoglucanase and 210 kDa ß-glucosidase., PLoS ONE, Vol.8, No.6, 2013.

4. Daisuke Kuchiike, Yoshihiro Uto, Hirotaka Mukai, Noriko Ishiyama, Chiaki Abe, Daichi Tanaka, Tomohito Kawai, Kentaro Kubo, Martin Mette, Toshio Inui, Yoshio Endo and Hitoshi Hori : Degalactosylated/Desialylated Human Serum Containing GcMAF Induces Macrophage Phagocytic Activity and In Vivo Antitumor Activity, Anticancer Research, Vol.33, No.7, pp.2881-2885, 2013.

5. Toshio Inui, Daisuke Kuchiike, Kentaro Kubo, Martin Mette, Yoshihiro Uto, Hitoshi Hori and Norihiro Sakamoto : Clinical Experience of Integrative Cancer Immunotherapy with GcMAF, Anticancer Research, Vol.33, No.7, pp.2917-2920, 2013.

6. Keiji Hirota, Yoshinori Nakagawa, Ryota Takeuchi, Yoshihiro Uto, Hitoshi Hori, Shinya Onizuka and Hiroshi Terada : Antitumor Effect of Degalactosylated Gc-Globulin on Orthotopic Grafted Lung Cancer in Mice, Anticancer Research, Vol.33, No.7, pp.2911-2915, 2013.

7. Masataka Nagahama, Naoyuki Shimomura, Akito Nakagawa, Kenji Teranishi, Yoshihiro Uto and Hitoshi Hori : In Vivo Experimental Study of Nanosecond Pulsed Electric Field Effects on Solid Tumors, IEEE Transactions on Dielectrics and Electrical Insulation, Vol.20, No.4, pp.1266-1272, 2013.

8. Junki Fukumoto, Mohd Nor Ismaliza Ismail, Masaki Kubo, Keita Kinoshita, Masahiro Inoue, Keizo Yuasa, Makoto Nishimoto, Hitoshi Matsuki and Akihiko Tsuji : Possible role of inter-domain salt bridges in oligopeptidase B from Trypanosoma brucei: critical role of Glu172 of non-catalytic -propeller domain in catalytic activity and Glu490 of catalytic domain in stability of OPB., The Journal of Biochemistry, Vol.154, No.5, pp.465-473, 2013.

9. Yu Kimura, Takuya Kurimoto, Hiro-aki Sugii, Akio Toshimitsu, Tetsuya Matsuda, Hirohiko Imai, Hisatsugu Yamada and Teruyuki Kondo : Novel Biocompatible Cobalt Oxide Nanoparticles for Use in Dual Photoacoustic and Magnetic Resonance Imaging, JSM Biotechnology & Biomedical Engineering, Vol.2, No.2, p.1043, 2014.

10. Ikuo Nakanishi, Tomonori Kawashima, Kei Ohkubo, Tsukasa Waki, Yoshihiro Uto, Tadashi Kamada, Toshihiko Ozawa, Ken-ichiro Matsumoto and Shunichi Fukuzumi : Disproportionation of a 2,2-diphenyl-1-picrylhydrazyl radical as a model of reactive oxygen species catalysed by Lewis and/or Brønsted acids, Chemical Communications, Vol.50, No.7, pp.814-816, 2014.

11. Megumi Ueno, Minako Nyui, Ikuo Nakanishi, Kazunori Anzai, Toshihiko Ozawa, Ken-ichiro Matsumoto and Yoshihiro Uto : Scavenging of reactive oxygen species induced by hyperthermia in biological fluid, Journal of Clinical Biochemistry and Nutrition, Vol.54, No.2, pp.75-80, 2014.

12. Chiaki Abe, Yoshihiro Uto, Ayaka Kawasaki, Chiho Noguchi, Ryo Tanaka, Toru Yoshitomi, Yukio Nagasaki, Yoshio Endo and Hitoshi Hori : Evaluation of the in vivo antioxidative activity of redox nanoparticles by using a developing chicken egg as an alternative animal model, Journal of Controlled Release, Vol.182, pp.67-72, 2014.

13. Akihiko Tsuji, Nami Nishiyama, Miki Ohshima, Saori Maniwa, Shuji Kuwamura, Masataka Shiraishi and Keizo Yuasa : Comprehensive enzymatic analysis of the amylolytic system in the digestive fluid of the sea hare, Aplysia kurodai: Unique properties of two α-amylases and two α-glucosidases, FEBS Open Bio, Vol.4, pp.560-570, 2014.

14. Shinya Matsuda, Kyohei Komiyato, Shizuyo Koide-Yoshida, Kenji Miyamoto, Kinuka Isshiki, Akihiko Tsuji and Keizo Yuasa : PCTAIRE Kinase 3/Cyclin-dependent Kinase 18 Is Activated through Association with Cyclin A and/or Phosphorylation by Protein Kinase A, The Journal of Biological Chemistry, Vol.289, No.26, pp.18387-18400, 2014.

15. Mami Ishikawa, Takahiro Inoue, Toshio Inui, Daisuke Kuchiike, Kentaro Kubo, Yoshihiro Uto and Takahito Nishikata : A novel assay system for macrophage-activating factor activity using a human U937 cell line, Anticancer Research, Vol.34, No.8, pp.4577-4581, 2014.

16. Ryu Tada, Yoshihiro Uto, Shin-ichiro Masunaga, Yuko Kinashi, Koji Ono and Hitoshi Hori : An NDT Study of a Boron Tracedrug UTX-51 for Glycated BSA as an AGE Model, Anticancer Research, Vol.34, No.8, pp.4503-4507, 2014.

17. Hitoshi Hori, Ryu Tada, Yoshihiro Uto, Eiji Nakata, Takashi Morii and Kai Masuda : A Neutron Dynamic Therapy with a Boron Tracedrug UTX-51 Using a Compact Neutron Generator, Anticancer Research, Vol.34, No.8, pp.4557-4560, 2014.

18. Yoshihiro Uto, Dai Tamatani, Yusuke Mizuki, Yoshio Endo, Ikuo Nakanishi, Kei Ohkubo, Shunichi Fukuzumi, Masahiro Ishizuka, Toru Tanaka, Daisuke Kuchiike, Kentaro Kubo, Toshio Inui and Hitoshi Hori : Evaluation of the Sonosensitizing Activities of 5-Aminolevulinic Acid and Sn(IV) Chlorin e6 in Tumor-bearing Chick Embryos, Anticancer Research, Vol.34, No.8, pp.4583-4587, 2014.

19. Toshio Inui, Kaori Makita, Hirona Miura, Akiko Matsuda, Daisuke Kuchiike, Kentaro Kubo, Martin Mette, Yoshihiro Uto, Takahito Nishikata, Hitoshi Hori and Norihiro Sakamoto : Case Report: A Breast Cancer Patient Treated with GcMAF, Sonodynamic Therapy and Hormone Therapy, Anticancer Research, Vol.34, No.8, pp.4589-4593, 2014.

20. Masataka Oita, Yoshihiro Uto, Masahide Tominaga, Motoharu Sasaki, Yasuo Hara, Taro Kishi and Hitoshi Hori : Radiosensitivity Uncertainty Evaluation for the In Vitro Biophysical Modeling of EMT6 Cells, Anticancer Research, Vol.34, No.8, pp.4621-4626, 2014.

21. R Munakata, T Inoue, T Koeduka, F Karamat, A Olry, A Sugiyama, K Takanashi, A Dugrand, Y Froelicher, R Tanaka, Yoshihiro Uto, Hitoshi Hori, J Azuma, A Hehn, F Bourgaud and K Yazaki : Molecular cloning and characterization of a geranyl diphosphate-specific aromatic prenyltransferase from lemon, Plant Physiology, Vol.166, No.1, pp.80-90, 2014.

22. Albert S. Reger, Matthew P. Yang, Koide-Yoshida Shizuyo, Elaine Guo, Shrenik Mehta, Keizo Yuasa, Alan Liu, Darren E. Casteel and Choel Kim : Crystal Structure of the cGMP-dependent Protein Kinase II Leucine Zipper and Rab11b Protein Complex Reveals Molecular Details of G-kinase-specific Interactions, The Journal of Biological Chemistry, Vol.289, No.37, pp.25393-25403, 2014.

23. Kim Hyejin, Atsushi Tabata, Toshifumi Tomoyasu, Ueno Tomomi, Uchiyama Shigeto, Keizo Yuasa, Akihiko Tsuji and Hideaki Nagamune : Estrogen stimuli promote osteoblastic differentiation via the subtilisin-like proprotein convertase PACE4 in MC3T3-E1 cells., Journal of Bone and Mineral Metabolism, Vol.33, No.1, pp.30-39, 2015.

24. Tsutomu Yoshimura, Yuanjun Di, Yu Kimura, Hisatsugu Yamada, Akio Toshimitsu and Teruyuki Kondo : Simple, Selective, and Practical Synthesis of 2-Substituted 4(3H)-Quinazolinones by Yb(OTf3)-Catalyzed Condensation of 2-Aminobenzamide with Carboxyamides, Heterocycles, Vol.90, No.2, pp.857-865, 2015.

25. Hisatsugu Yamada, Yoshinori Hasegawa, Hirohiko Imai, Yuki Takayama, Fuminori Sugihara, Tetsuya Matsuda, Hidehito Tochio, Masahiro Shirakawa, Shinsuke Sando, Yu Kimura, Akio Toshimitsu, Yasuhiro Aoyama and Teruyuki Kondo : Magnetic resonance imaging of tumor with a self-traceable phosphorylcholine polymer., Journal of the American Chemical Society, Vol.137, No.2, pp.799-806, 2015.

26. Hisatsugu Yamada, Yoshinori Hasegawa, Yuki Suzuki, Hirohiko Imai, Tetsuya Matsuda, Yu Kimura, Akio Toshimitsu, Yasuhiro Aoyama and Teruyuki Kondo : Magnetic Resonance Imaging of Tumor with a Self-Traceable Polymer Conjugated with an Antibody Fragment, Bioorganic & Medicinal Chemistry Letters, Vol.25, No.13, pp.2675-2678, 2015.

27. Yoshihiro Uto, Tomohito Kawai, Toshihide Sasaki, Ken Hamada, Hisatsugu Yamada, Daisuke Kuchiike, Kentaro Kubo, Toshio Inui, Martin Mette, Ken Tokunaga, Akio Hayakawa, Akiteru Go and Tomohiro Oosaki : Degalactosylated/Desialylated Bovine Colostrum Induces Macrophage Phagocytic Activity Independently of Inflammatory Cytokine Production., Anticancer Research, Vol.35, No.8, pp.4487-4492, 2015.

28. Toshio Inui, Kentaro Kubo, Daisuke Kuchiike, Yoshihiro Uto, Takahito Nishikata, Norihiro Sakamoto and Martin Mette : Oral Colostrum Macrophage-activating Factor for Serious Infection and Chronic Fatigue Syndrome: Three Case Reports., Anticancer Research, Vol.35, No.8, pp.4545-4549, 2015.

29. Yu Sumiya, Mami Ishikawa, Takahiro Inoue, Toshio Inui, Daisuke Kuchiike, Kentaro Kubo, Yoshihiro Uto and Takahito Nishikata : Macrophage Activation Mechanisms in Human Monocytic Cell Line-derived Macrophages., Anticancer Research, Vol.35, No.8, pp.4447-4451, 2015.

30. Takahiro Inoue, Mami Ishikawa, Yu Sumiya, Haruka Kohda, Toshio Inui, Daisuke Kuchiike, Kentaro Kubo, Yoshihiro Uto and Takahito Nishikata : Establishment of a Macrophage-activating Factor Assay System Using the Human Monocytic Cell Line THP-1., Anticancer Research, Vol.35, No.8, pp.4441-4445, 2015.

31. Keizo Yuasa, Reina Ota, Matsuda Shinya, Kinuka Isshiki, Masahiro Inoue and Akihiko Tsuji : Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins, Biochemical and Biophysical Research Communications, Vol.464, No.1, pp.70-75, 2015.

32. Yuki Yoshikatsu, Yo-ichi Ishida, Haruka Sudo, Keizo Yuasa, Akihiko Tsuji and Masami Nagahama : NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing, Biochemical and Biophysical Research Communications, Vol.464, No.3, pp.780-786, 2015.

33. Yuka Miyake, Ishikawa Syngo, Yu Kimura, Aoi Son, Hirohiko Imai, Tetsuya Matsuda, Hisatsugu Yamada, Akio Toshimitsu and Teruyuki Kondo : Pharmacokinetics of Chiral Dendrimer-Triamine-Coordinated Gd-MRI Contrast Agents Evaluated by in Vivo MRI and Estimated by in Vitro QCM, Sensors, Vol.15, No.12, pp.31973-31986, 2015.

34. Kinuka Isshiki, Taishi Hirase, Shinya Matsuda, Kenji Miyamoto, Akihiko Tsuji and Keizo Yuasa : Death-associated protein kinase 2 mediates nocodazole-induced apoptosis through interaction with tubulin, Biochemical and Biophysical Research Communications, Vol.468, No.1-2, pp.113-118, 2015.

35. Tomohiro Osaki, Inoru Yokoe, Yoshihiro Uto, Masahiro Ishizuka, Tohru Tanaka, Nobuyasu Yamanaka, Tsukasa Kurahashi, Kazuo Azuma, Yusuke Murahata, Takeshi Tsuka, Norihiko Ito, Tomohiro Imagawa and Yoshiharu Okamoto : Bleomycin enhances the efficacy of sonodynamic therapy using aluminum phthalocyanine disulfonate., Ultrasonics Sonochemistry, Vol.28, (号), pp.161-168, 2016.

36. James C. Campbell, Jeong Joo Kim, Kevin Y. Li, Gilbert Y. Huang, Albert S. Reger, Shinya Matsuda, Banumathi Sankaran, Todd M. Link, Keizo Yuasa, John E. Ladbury, Darren E. Casteel and Choel Kim : Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II, The Journal of Biological Chemistry, Vol.291, No.11, pp.5623-5633, 2016.

【総説・解説】

1. 宇都 義浩, 堀 均 : 放射線療法と免疫反応/療法を組み合わせた統合的がん治療の基礎と臨床:マクロファージ活性化因子GcMAFの利用可能性, 放射線生物研究, Vol.48, No.2, 199-210頁, 2013年6月.

【国際会議 Proceedings】

1. Akito Nakagawa, Masataka Nagahama, Kenji Teranishi, Yoshihiro Uto and Naoyuki Shimomura : Effects of Applied Ultrashort Pulsed Electric Fields on Solid Tumor, Proceedings of the 2014 IEEE International Power Modulator and High Voltage Conference, pp.45-48, Santa Fe, June 2014.

2. Akihiro Shirai, Matsumura Kyohei, Masayoshi Onitsuka, Hideaki Maseda and Takeshi Omasa : Application of photochromism to the molecular design of antimicrobial agents: synthesis of phenolic derivatives and their bactericidal activity based on a photo-reaction with ultraviolet-A light, III International Conference on Antimicrobial Research, No.T64, p.289, Madrid, Oct. 2014.

3. Matsuda Shinya, Kominato Kyohei, Akihiko Tsuji and Keizo Yuasa : PCTAIRE kinase 3/cyclin dependent kinase 18 is activated through association with cyclin A and/or phosphorylation by protein kinase A, Experimental Biology 2015, Boston, Massachusetts, March 2015.

4. Takehiro Hara, Masahide Tominaga, Hideaki Endo and Yoshihiro Uto : The effect of dose rate on radiation-induced in vitro antitumor activity by low-LET radiation., 15th International Congress of Radiation Research (ICRR2015), (都市), May 2015.

5. Ryu Tada, Hitoshi Hori, Shinichiro Masunaga, Yuko Kinashi, Koji Ono and Yoshihiro Uto : NDT-based Approach of Boron tracedrug UTX-51 to Glycated BSA as a AGE model., 15th International Congress of Radiation Research (ICRR2015), (都市), May 2015.

6. Shuzo Matsubara, Akito Nakagawa, Shota Kuniyasu, Kenji Teranishi, Yoshihiro Uto and Naoyuki Shimomura : Investigation of Effect of Applied Nanosecond Pulsed Electric Fields on Tumor, Proceedings of the 20th IEEE Pulsed Power Conference, pp.374-378, Austin, June 2015.

7. James C. Campbell, Kevin Y. Li, Jeong Joo Kim, Gilbert Huang, Albert S. Reger, Shinya Matsuda, Banumathi Sankaran, Todd M. Link, Keizo Yuasa, John E. Ladbury and Choel Kim : Structural basis of cyclic nucleotide selectivity in cGMP dependent protein kinase II, 7th International Conference on cGMP cGMP: Generators, Effectors and Therapeutic Implications, Trier, Germany, June 2015.

8. Yoshihiro Uto, Tomohito Kawai, Toshihide Sasaki, Ken Hamada, Saki Ikame, Eri Kuwada, Hisatsugu Yamada, Kentaro Kubo, Daisuke Kuchiike, Martin Mette, Toshio Inui, Ken Tokunaga, Akio Hayakawa, Akitetsu Go and Tomohiro Oosaki : Development of Macrophage Activating Glycoproteins by Using Bovine Colostrum as an Immunotherapeutic agent., 9th International Symposium on Nanomedicine (ISNM2015), (都市), Nov. 2015.

9. Hisatsugu Yamada, Yoshinori Hasegawa, Hirohiko Imai, Yuki Takayama, Fuminori Sugihara, Tetsuya Matsuda, Hidehito Tochio, Masahiro Shirakawa, Shinsuke Sando, Yu Kimura, Akio Toshimitsu, Yasuhiro Aoyama and Teruyuki Kondo : Magnetic resonance imaging of tumor with a self-traceable phosphorylcholine polymer., IKCOC-13, Kyoto, Nov. 2015.

10. Junpei Hashimoto, Miyuki Oshimura, Tomohiro Hirano, Yoshihiro Uto and Koichi Ute : Stereospecific radical polymerization of methacrylamide derivatives in the presence of lithium salts, 14th Pacific Polymer Conference, Kauai, Dec. 2015.

11. Natsuki Matsumoto, Hisatsugu Yamada, Yu Kimura, Akio Toshimitsu, Yasuhiro Aoyama and Teruyuki Kondo : Biocompatible Phosphorylchline Polymer Probes for In Vivo Photoacoustic Imaging, Pacifichem 2015, Honolulu, HI, Dec. 2015.

12. Yuki Suzuki, Hisatsugu Yamada, Yu Kimura, Aoi Son, Kazuhito Tanabe, Akio Toshimitsu, Yasuhiro Aoyama and Teruyuki Kondo : A New Theranostic Probe for Tumor Hypoxia Based on Triple-resonance NMR and Radio-sensitization, Pacifichem 2015, (巻), (号), (頁), Honolulu, HI, Dec. 2015.

13. Hisatsugu Yamada, Yoshinori Hasegawa, Yu Kimura, Hirohiko Imai, Tetsuya Matsuda, Yoshihiro Uto, Yasuhiro Aoyama and Teruyuki Kondo : Probe-Targeted Magnetic Resonance Imaging of Tumor with A Self-Traceable ¹H-¹³C Polymeric Nanoprobe, Pacifichem 2015, (巻), (号), (頁), Honolulu, HI, Dec. 2015.

14. Yoshihiro Uto, Hisatsugu Yamada, Daisuke Kuchiike, Kentaro Kubo, Toshio Inui, Martin Mette, Ken Tokunaga, Akio Hayakawa, Akitetsu Go and Tomohiro Oosaki : Degalactosylated/desialylated human serum and bovine colostrum induces macrophage phagocytic activity., Pacifichem 2015, (巻), (号), (頁), Honolulu, HI, Dec. 2015.

15. Ryu Tada, Hisatsugu Yamada, Eiji Nakata, Kai Masuda, Takashi Morii and Yoshihiro Uto : Development of a PARP-inhibiting boron tracedrug for neutron dynamic therapy, Pacifichem 2015, (巻), (号), (頁), Honolulu, HI, Dec. 2015.

【特許・実用新案】

1. 近藤 輝幸, 青山 安宏, 山田 久嗣, 長谷川 嘉則, 杤尾 豪人, 木村 祐, 白川 昌宏, 杉原 文徳, 松田 哲也, 山東 信介, 南 昌人, 山内 文生, 矢野 哲哉, 都築 英寿 : 重合体，前記重合体を用いた核磁気共鳴分析用または磁気共鳴イメージング用の造影剤，化合物，前記重合体を用いた核磁気共鳴分析方法および磁気共鳴イメージング方法, 特願2012-118061 (2012年5月), 特開2014-1371 (2014年1月), (番号) ((年月日)).

2. Yoshihiro Uto, Hitoshi Hori, 乾 利夫 and 久保 健太郎 : Pharmaceutical composition and method of preparing same, US 13/988,376 (Sep. 2012), (開示), US8,747,919 (June 2014).

3. 宇都 義浩, 堀 均, 乾 利夫, 久保 健太郎 : 医薬組成物およびその製造方法, 特願2012-551822 (2012年9月), (開示), 特許第5860817号 (2015年12月).

4. 近藤 輝幸, 青山 安宏, 山田 久嗣, 今井 宏彦, 高山 裕生, 長谷川 嘉則, 木村 祐, 杤尾 豪人, 白川 昌宏, 杉原 文徳, 年光 昭夫, 松田 哲也, 山東 信介, 都築 英 : 多核多重核磁気共鳴画像化方法, 特願2013-45724 (2013年3月), 特開WO2014136905 A1 (2014年9月), (番号) ((年月日)).

5. 近藤 輝幸, 青山 安宏, 山田 久嗣, 長谷川 嘉則, 杤尾 豪人, 木村 祐, 白川 昌宏, 杉原 文徳, 松田 哲也, 山東 信介, 南 昌人, 山内 文生, 矢野 哲哉, 都築 英寿 : 重合体，前記重合体を用いた核磁気共鳴分析用または磁気共鳴イメージング用の造影剤，化合物，前記重合体を用いた核磁気共鳴分析方法および磁気共鳴イメージング方法, 特願2013-103159 (2013年5月), 特開2014-1371 (2014年1月), (番号) ((年月日)).

6. 近藤 輝幸, 青山 安宏, Hisatsugu Yamada, 長谷川 嘉則, 杤尾 豪人, 木村 祐, 白川 昌宏, 杉原 文徳, 松田 哲也, 山東 信介, 南 昌人, 山内 文生, 矢野 哲哉 and 都築 英寿 : POLYMER, CONTRAST AGENT FOR NUCLEAR MAGNETIC RESONANCE ANALYSIS OR MAGNETIC RESONANCE IMAGING USING THE POLYMER, COMPOUND, AND METHOD OF NUCLEAR MAGNETIC RESONANCE ANALYSIS AND METHOD OF MAGNETIC RESONANCE IMAGING USING THE POLYMER, PCT/JP2013/064819 (May 2013), WO2013176292 A3 (March 2014), (番号) ((年月日)).

7. 近藤 輝幸, 青山 安宏, 山田 久嗣, 今井 宏彦, 高山 裕生, 長谷川 嘉則, 木村 祐, 杤尾 豪人, 白川 昌宏, 杉原 文徳, 年光 昭夫, 松田 哲也, 山東 信介, 都築 英 : 多核多重核磁気共鳴画像化方法, 特願PCT/JP2014/055848 (2014年3月), 特開WO2014136905 A1 (2014年9月), (番号) ((年月日)).

8. 近藤 輝幸, 青山 安宏, 山田 久嗣, 長谷川 嘉則, 山東 信介, 木村 祐, 山内 文生, 矢野 哲哉, 南 昌人, 高橋 淳, 金﨑 健吾, 小河 賢史 : 重合体，前記重合体を有する光音響イメージング用造影剤, 特願2014-217451 (2014年10月), (開示), (番号) ((年月日)).

9. 白井 昭博, 延嶋浩文 (名) : 抗菌・抗黴性ピリジン化合物，抗菌・抗黴性樹脂組成物，及び樹脂成形品, 特願2015-087255 (2015年4月), (開示), (番号) ((年月日)).

II.4.5 生命機能工学

生体膜脂質の物性研究に基づく高圧適応技術の開発やリポソームなどの医用ツー ルの開発. 生体の形作りと機能を制御する遺伝子発現のネットワークに関する 研究とmRNA発現制御技術の応用研究.

II.4.5.1 教員組織

(1) 氏名，(2) メールアドレス，(3) 職名・学位，(4) 専門分野，(5) 所属学会（役職名），(6) 社会活動（役職名），(7) 主要研究テーマ，(8) キーワード，(9) 共同研究可能テーマ

(1) 松木 均, Hitoshi Matsuki, (2) mātśūkī (@) bīō ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 教授・博士(理学), (4) 生物物理化学, コロイドおよび界面化学, 高圧生物科学, (5) 社団法人 日本化学会・日本高圧力学会 (学会誌編集委員長, 学会誌副編集委員長)・日本熱測定学会 (企画幹事)・日本生物物理学会 (分野別専門委員)・日本材料学会 (極限環境部門委員会幹事)・日本油化学会・日本膜学会・日本麻酔メカニズム研究グループ (世話人)・アメリカ化学会・コロイドおよび界面科学者国際連合, (6) , (7) 高圧力下における生体関連物質の挙動, 膜作用性薬物と生体モデル膜の相互作用, 界面活性物質の分子集合体形成, (8) 分子集合体, 麻酔分子機構, 高圧力, 表面張力, 非特異的分子間相互作用, (9) 分子集合系の物理化学特性, 生体関連物質への圧力効果, 界面活性物質の評価

(1) 櫻谷 英治, Eiji Sakuradani, (2) śākūŗāđāņī ₍.₎ ėījī (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 教授(学位名称), (4) (@.field), (5) 日本醸造学会 (若手の会運営委員)・日本生物工学会 (西日本支部庶務, 西日本支部評議員)・社団法人 日本農芸化学会 (広報委員, 学術活動委員)・糸状菌分子生物学研究会 (運営委員)・一般財団法人バイオインダストリー協会・酵素工学研究会・Applied Microbiology and Biotechnology (Editorial Board Members), (6) , (7) (@.theme), (8) (@.keyword), (9) (@.collaborate)

(1) 玉井 伸岳, Nobutake Tamai, (2) tāmāī (@) bīō ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 准教授・博士(農学), (4) 生物物理化学, (5) 社団法人 日本化学会・日本高圧力学会・日本レオロジー学会・社団法人 高分子学会・セルロース学会・日本生物物理学会 (分野別専門委員), (6) , (7) 脂質膜の構造特性に関する物理化学的研究, (8) 生物物理化学, 分散系のレオロジー, コロイドおよび界面化学, (9) 生体関連物質への圧力効果, 分散系のレオロジー, 生体高分子の希薄溶液物性

(1) 芥川 正武, Masatake Akutagawa, (2) mākūtāġā (@) ėė ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 講師・博士(工学), (4) 医用生体工学, (5) 電子情報通信学会・日本ME学会・日本磁気歯科学会 (広報委員長)・電子情報通信学会・計測自動制御学会 (生体・生理工学部会運営委員)・社団法人 日本生体医工学会・IEEE (Secretary), (6) 財団法人 医療機器センター (臨床工学技士試験委員), (7) 脳波を用いた脳機能解析, 集中治療室の情報処理システム, 生体インピーダンス測定装置の開発, 頸動脈血流速度の解析, ライフサイエンスへのLEDの応用, 生体信号解析, ニューラルネットワークと磁界を用いた顎運動計測, Analysis of MRI metal artifacts by dental prosthesis, (8) ニューラルネットワーク, MRI, 殺菌, 発光ダイオード, 血流, 生体電気インピーダンス, 磁界計測, 顎運動, (9) (@.collaborate)

(1) 榎本 崇宏, Takahiro Emoto, (2) ėmōtō (@) ėė ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 講師・博士(工学), (4) 生体医工学, (5) 社団法人 日本生体医工学会・IEEE, (6) 電子情報通信学会, (7) 生体信号解析に基づく医療診断支援, (8) 生体計測,生体信号処理,医療機器開発, (9) 生体医工学分野

(1) 三戸 太郎, Taro Mito, (2) mītō (@) bīō ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 助教・博士(理学), (4) 発生工学, 分子生物学, (5) 日本発生生物学会・社団法人 日本動物学会・日本古生物学会, (6) , (7) 昆虫の発生·再生と進化のメカニズム, (8) 発生, 再生, 進化, 昆虫, (9) 無脊椎動物の発生·再生·進化に関する遺伝子レベルでの研究

(1) 後藤 優樹, Masaki GOTO, (2) ġōtō (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 助教・博士(工学), (4) 生物物理化学, 口腔衛生学, (5) 社団法人 日本化学会・日本高圧力学会・日本口腔衛生学会・日本麻酔メカニズム研究会・日本生物物理学会, (6) , (7) 脂質・界面活性剤二重膜の高圧物性, ホスホリルコリンに対する粘膜免疫応答, (8) 脂質二重膜, 界面活性剤, 高圧, 相転移, 蛍光イメージング, 放射光, 構造解析, 膜融合, 粘膜免疫, 動脈硬化, ホスホリルコリン, (9) 高圧力研究

(1) 阪本 鷹行, Takaiku Sakamoto, (2) śākāmōtō ₍.₎ tākāīkū (@) tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp, (3) 助教・博士(環境科学), (4) 分子生物学, 応用微生物学, (5) 社団法人 日本農芸化学会・日本生物工学会・日本菌学会・糸状菌分子生物学研究会・日本きのこ学会, (6) , (7) バイオマス資源を利用した機能性物質の微生物発酵生産, (8) (@.keyword), (9) (@.collaborate)

II.4.5.2 研究業績

【著　　書】

1. 松木 均, 玉井 伸岳 : 進化する食品高圧加工技術 -基礎から最新の応用事例まで-, --- 第1編 基礎編, 第2章 生体物質および生物への高圧力の影響とその作用メカニズム, 第3節 脂質 ---, 株式会社エヌ·ティー·エス, 東京, 2013年6月.

2. 渡辺 崇人, 三戸 太郎, 大内 淑代, 野地 澄晴 : 第10章 コオロギにおけるZFN，TALEN，CRISPR/Cas9を用いた遺伝子改変, 羊土社, (都市), 2014年4月.

3. 松木 均 : 極限環境の生体分子(CSJカレントレビュー17), --- 9章 生体膜と圧力 ---, 株式会社 化学同人, 京都, 2014年11月.

4. 渡辺 崇人, 松岡 佑児, 野地 澄晴, 三戸 太郎 : 進化するゲノム編集技術(真下知士, 城石俊彦監修)第2編第2章第4節 フタホシコオロギにおけるゲノム編集, エヌ・ティー・エス, (都市), 2015年1月.

5. Kazuyuki Akasaka and Hitoshi Matsuki : High Pressure Bioscience - Basic Concepts, Applications and Frontiers, Springer, Dordrecht, Aug. 2015.

6. Hitoshi Matsuki : High Pressure Bioscience - Basic Concepts, Applications and Frontiers, --- How Do Membranes Respond to Pressure? ---, Springer, Dordrecht, Aug. 2015.

7. 松木 均, 後藤 優樹, 玉井 伸岳, 金品 昌志 : 高圧バイオサイエンスとバイオテクノロジー, --- 第17章 リン脂質二重膜の圧力誘起膜融合:巨大単層ベシクルの球形成長 ---, 三恵社, 名古屋, 2015年11月.

8. Takahito Watanabe, Sumihare Noji and Taro Mito : GeneKnockout by Targeted Mutagenesis in a Hemimetabolous Insect, the Two-Spotted Cricket Gryllus bimaculatus, using TALENs. In TALENs: Methods and Protocols (Ralf Kuhn et al. eds.), Springer, New York, (month)2016.

【学術論文】

1. Eiji Sakuradani, Yusuke Natsume, Yasushi Takimura, Jun Ogawa and Sakayu Shimizu : Subterminal oxidation of n-alkanes in achlorophyllous alga Prototheca sp., Journal of Bioscience and Bioengineering, Vol.116, No.4, pp.472-474, 2013.

2. V Zeng, B Ewen-Campen, HW Horch, S Roth, Taro Mito and CG Extavour : Developmental gene discovery in a hemimetabolous insect: de novo assembly and annotation of a transcriptome for the cricket Gryllus bimaculatus., PLoS ONE, Vol.8, No.5, p.e61479, 2013.

3. Takaiku Sakamoto, Yoichi Honda, Isamu Kameshita, Kazumi Suzuki and Toshikazu Irie : Isolation and heterologous expression of the Phanerochaete chrysosporium calmodulin gene, Mycoscience, Vol.54, No.3, pp.241-246, 2013.

4. Hiroshi Kikukawa, Eiji Sakuradani, Shigenobu Kishino, Si-Bum Park, Akinori Ando, Jun Shima, Misa Ochiai, Sakayu Shimizu and Jun Ogawa : Characterization of a trifunctional fatty acid desaturase from oleaginous filamentous fungus Mortierella alpina 1S-4 using a yeast expression system., Journal of Bioscience and Bioengineering, Vol.116, No.6, pp.672-676, 2013.

5. Nobutake Tamai, Sayuri Kakibe, Tanaka Saeko, Masaki GOTO and Hitoshi Matsuki : An Attempt to Reveal Viscoelastic Behavior of Lipid Bilayer Membrane by Pressure Perturbation Calorimetry, High Pressure Research, Vol.33, No.2, pp.271-277, 2013.

6. Nobutake Tamai, Takuya Izumikawa, Suguru Fukui, Maiko Uemura, Masaki GOTO, Hitoshi Matsuki and Shoji Kaneshina : How Does Acyl-chain Length Affect Thermotropic Phase Behavior of Saturated Diacylphosphatidylcholine-chloresterol Binary Bilayers?, Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol.1828, No.11, pp.2513-2523, 2013.

7. Takahiro Emoto, Shono Koichi, Udantha R. Abeyratne, Toshiya Okahisa, Hiromi Yano, Masatake Akutagawa, Shinsuke Konaka and Yohsuke Kinouchi : ARMA based spectral bandwidth for evaluation of bowel motility by the analysis of bowel sounds, Physiological Measurement, Vol.34, No.8, pp.925-936, 2013.

8. Junki Fukumoto, Mohd Nor Ismaliza Ismail, Masaki Kubo, Keita Kinoshita, Masahiro Inoue, Keizo Yuasa, Makoto Nishimoto, Hitoshi Matsuki and Akihiko Tsuji : Possible role of inter-domain salt bridges in oligopeptidase B from Trypanosoma brucei: critical role of Glu172 of non-catalytic -propeller domain in catalytic activity and Glu490 of catalytic domain in stability of OPB., The Journal of Biochemistry, Vol.154, No.5, pp.465-473, 2013.

9. Yasushi Takimura, Eiji Sakuradani, Yusuke Natsume, Takashi Miyake, Jun Ogawa and Sakayu Shimizu : Achlorophyllous alga Prototheca zopfii oxidizes n-alkanes with different carbon-chain lengths through a unique subterminal oxidation pathway., Journal of Bioscience and Bioengineering, Vol.117, No.3, pp.275-277, 2013.

10. Chihiro Sato Matsumoto, Hisashi Shidara, Koji Matsuda, Taro Nakamura, Taro Mito, Yukihisa Matsumoto, Kotaro Oka and Hiroto Ogawa : Targeted gene delivery in the cricket brain, using in vivo electroporation., Journal of Insect Physiology, Vol.59, No.12, pp.1235-1241, 2013.

11. Yuki Yao, Takaiku Sakamoto, Yoichi Honda, Yasuyuki Kagotani, Kousuke Izumitsu, Kazumi Suzuki and Toshikazu Irie : The white-rot fungus pleurotus ostreatus transformant overproduced intracellular cAMP and laccase., Bioscience, Biotechnology, and Biochemistry, Vol.77, No.11, pp.2309-2311, 2013.

12. Ayumi Tanimura, Masako Takashima, Takashi Sugita, Rikiya Endoh, Minako Kikukawa, Shino Yamaguchi, Eiji Sakuradani, Jun Ogawa and Jun Shima : Selection of oleaginous yeasts with high lipid productivity for practical biodiesel production., Bioresource Technology, Vol.153, (号), pp.230-235, 2013.

13. Hiroki Kitayama, Yuki Takechi, Nobutake Tamai, Hitoshi Matsuki, Chikako Yomota and Hiroyuki Saito : Thermotropic phase behavior of hydrogenated soybean phosphatidylcholine-cholesterol binary liposome membrane., Chemical & Pharmaceutical Bulletin, Vol.62, No.1, pp.58-63, 2014.

14. Mutsumi Aihara, Xin Lian, Takaaki Shimohata, Takashi Uebansou, Kazuaki Mawatari, Yumi Harada, Masatake Akutagawa, Yohsuke Kinouchi and Akira Takahashi : Vegetable surface sterilization system using UVA light-emitting diodes., The Journal of Medical Investigation : JMI, Vol.61, No.3-4, pp.285-290, 2014.

15. Yang Yi, Shinsuke Konaka, Masatake Akutagawa, Takahiro Emoto and Qinyu Zhang : Cognitive Engine Design for Cognitive Radio in LTE-Advanced Communication Frame Based on Modified Particle Swarm Optimization, ICIC Express Letters, Vol.8, No.3, pp.843-850, 2014.

16. Takahito Watanabe, Sumihare Noji and Taro Mito : Gene knockout by targeted mutagenesis in a hemimetabolous insect, the two-spotted cricket Gryllus bimaculatus, using TALENs., Methods, Vol.69, No.1, pp.17-21, 2014.

17. Hiroshi Yoshida, Tetsuya Bando, Taro Mito, Hideyo Ohuchi and Sumihare Noji : An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system., Scientific Reports, Vol.4, (号), p.4335, 2014.

18. Tomoyo Okuda, Akinori Ando, Eiji Sakuradani, Hiroshi Kikukawa, Nozomu Kamada, Misa Ochiai, Jun Shima and Jun Ogawa : Characterization of galactose-dependent promoters from an oleaginous fungus Mortierella alpina 1S-4., Current Genetics, Vol.60, No.3, pp.175-182, 2014.

19. Tomoyo Okuda, Akinori Ando, Eiji Sakuradani, Hiroshi Kikukawa, Nozomu Kamada, Misa Ochiai, Jun Shima and Jun Ogawa : Selection and characterization of promoters based on genomic approach for the molecular breeding of oleaginous fungus Mortierella alpina 1S-4., Current Genetics, Vol.60, No.3, pp.183-191, 2014.

20. 新田 佳伯, 芥川 正武, 榎本 崇宏, 岡久 稔也, 宮本 弘志, 大西 芳明, 木内 陽介, S. Abhijit PANDYA : 体外循環療法中に腎臓で行われる水分の再吸収効率の推定, 医工学治療, Vol.26, No.1, 24-31頁, 2014年.

21. Ayumi Tanimura, Masako Takashima, Takashi Sugita, Rikiya Endoh, Minako Kikukawa, Shino Yamaguchi, Eiji Sakuradani, Jun Ogawa, Moriya Ohkuma and Jun Shima : Cryptococcus terricola is a promising oleaginous yeast for biodiesel production from starch through consolidated bioprocessing., Scientific Reports, Vol.4, (号), p.4776, 2014.

22. Mutsumi Nakahashi, Kazuaki Mawatari, Akiko Hirata, Miki Maetani, Takaaki Shimohata, Takashi Uebansou, Yasuhiro Hamada, Masatake Akutagawa, Yohsuke Kinouchi and Akira Takahashi : Simultaneous irradiation with different wavelengths of ultraviolet light has synergistic bactericidal effect on Vibrio parahaemolyticus., Photochemistry and Photobiology, Vol.90, No.6, pp.1397-1403, 2014.

23. Akihiro Yasue, Silvia Naomi MITSUI AKAGI, Takahito Watanabe, Tetsushi Sakuma, Seiichi Oyadomari, Takashi Yamamoto, Sumihare Noji, Taro Mito and Eiji Tanaka : Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by the TALEN and CRISPR/Cas systems., Scientific Reports, Vol.4, p.5705, 2014.

24. 松木 均, 後藤 優樹, 玉井 伸岳 : 脂質膜の圧力誘起指組構造形成:疎水鎖長依存性と形成限界, 材料, Vol.63, No.8, 620-623頁, 2014年.

25. Takahiro Emoto, Masato Kashihara, Udantha R. Abeyratne, Osamu Jinnouchi, Ikuji Kawata, Masatake Akutagawa, Shinsuke Konaka and Yohsuke Kinouchi : Signal shape feature for automatic snore and breathing sounds classification, Physiological Measurement, Vol.35, No.12, pp.2489-2499, 2014.

26. Eiji Sakuradani, Hiroshi Kikukawa, Seiki Takeno, Akinori Ando, Sakayu Shimizu and Jun Ogawa : Transformation of zygomycete Mortierella alpina using biolistic particle bombardment, Genetic Transformation Systems in Fungi., Vol.1, pp.135-140, 2014.

27. Takashi Suetomi, Takaiku Sakamoto, Yoshitaka Tokunaga, Toru Kameyama, Yoichi Honda, Hisatoshi Kamitsuji, Isamu Kameshita, Kousuke Izumitsu, Kazumi Suzuki and Toshikazu Irie : Effects of calmodulin on expression of lignin-modifying enzymes in Pleurotus ostreatus., Current Genetics, Vol.61, No.2, pp.127-140, 2014.

28. Hiroshi Kikukawa, Eiji Sakuradani, Akinori Ando, Tomoyo Okuda, Misa Ochiai, Sakayu Shimizu and Jun Ogawa : Disruption of lig4 improves gene targeting efficiency in the oleaginous fungus Mortierella alpina 1S-4., Journal of Biotechnology, Vol.208, (号), pp.63-69, 2015.

29. H Kikukawa, Eiji Sakuradani, Y Nishibaba, T Okuda, A Ando, J Shima, S Shimizu and J Ogawa : Production of cis-11-eicosenoic acid by Mortierella fungi., Journal of Applied Microbiology, Vol.118, No.3, pp.641-647, 2015.

30. Yoshiyasu Ishimaru, Taro Nakamura, Tetsuya Bando, Yuji Matsuoka, Hideyo Ohuchi, Sumihare Noji and Taro Mito : Involvement of dachshund and Distal-less in distal pattern formation of the cricket leg during regeneration., Scientific Reports, Vol.5, p.8387, 2015.

31. Hiroshi Kikukawa, Eiji Sakuradani, Masato Nakatani, Akinori Ando, Tomoyo Okuda, Takaiku Sakamoto, Misa Ochiai, Sakayu Shimizu and Jun Ogawa : Gene targeting in the oil-producing fungus Mortierella alpina 1S-4 and construction of a strain producing a valuable polyunsaturated fatty acid., Current Genetics, Vol.61, No.4, pp.579-589, 2015.

32. Masaki GOTO, Takuya Endo, Takahiro Yano, Nobutake Tamai, Joachim Kohlbrecher and Hitoshi Matsuki : Comprehensive characterization of temperature- and pressure-induced bilayer phase transitions for saturated phosphatidylcholines containing longer chain homologs, Colloids and Surfaces B:Biointerfaces, Vol.128, pp.389-397, 2015.

33. Tomoyo Okuda, Akinori Ando, Hiroaki Negoro, Hiroshi Kikukawa, Takaiku Sakamoto, Eiji Sakuradani, Sakayu Shimizu and Jun Ogawa : Omega-3 eicosatetraenoic acid production by molecular breeding of the mutant strain S14 derived from Mortierella alpina 1S-4., Journal of Bioscience and Bioengineering, Vol.120, No.3, pp.299-304, 2015.

34. Yuji Matsuoka, Tetsuya Bando, Takahito Watanabe, Yoshiyasu Ishimaru, Sumihare Noji, Aleksandar Popadic and Taro Mito : Short germ insects utilize both the ancestral and derived mode of Polycomb group-mediated epigenetic silencing of Hox genes., Biology Open, Vol.4, No.6, pp.702-709, 2015.

35. Toshitaka Ikehara, Mutsumi Nakahashi, Zehong Su, Masatake Akutagawa, Koichiro Tsuchiya, Mitsuo Kitamura, Akira Takahashi and Yohsuke Kinouchi : Effects of UV-A LED light irradiation on growth of cultured RAW 264.7 cells, Toxicological and Environmental Chemistry, Vol.97, No.2, pp.243-255, 2015.

36. Tomoyo Okuda, Akinori Ando, Hiroaki Negoro, Tatsuya Muratsubaki, Hiroshi Kikukawa, Takaiku Sakamoto, Eiji Sakuradani, Sakayu Shimizu and Jun Ogawa : Eicosapentaenoic acid (EPA) production by an oleaginous fungus Mortierella alpina expressing heterologous 17-desaturase gene under ordinary temperature, European Journal of Lipid Science and Technology : EJLST, Vol.117, No.12, pp.1919-1927, 2015.

37. Yoshimasa Hamada, Tetsuya Bando, Taro Nakamura, Yoshiyasu Ishimaru, Taro Mito, Sumihare Noji, Kenji Tomioka and Hideyo Ohuchi : Regenerated leg segment patterns are regulated epigenetically by histone H3K27 methylation in the cricket Gryllus bimaculatus, Development, Vol.142, No.17, pp.2916-2927, 2015.

38. Hiroko Awata, Takahito Watanabe, Yoshitaka Hamanaka, Taro Mito, Sumihare Noji and Makoto Mizunami : Knockout crickets for the study of learning and memory: Dopamine receptor Dop1 mediates aversive but not appetitive reinforcement in crickets, Scientific Reports, Vol.5, (号), p.15885, 2015.

39. Ryo Nonaka, Takahiro Emoto, Udantha R. Abeyratne, Osamu Jinnouchi, Ikuji Kawata, Hiroki Ohnishi, Masatake Akutagawa, Shinsuke Konaka and Yohsuke Kinouchi : Automatic snore sound extraction from sleep sound recordings via auditory image modeling, Biomedical Signal Processing and Control, Vol.27, (号), pp.7-14, 2016.

40. Yanfei Hou, Mutsumi Nakahashi, Kazuaki Mawatari, Takaaki Shimohata, Takashi Uebansou, Yumi Harada, Akari Tsunedomi, Takahiro Emoto, Masatake Akutagawa, Yohsuke Kinouchi and Akira Takahashi : Combined treatment of UVA irradiation and antibiotics induces greater bactericidal effects on Vibrio parahaemolyticus., The Journal of Medical Investigation : JMI, Vol.63, No.1-2, pp.63-67, 2016.

41. Hiroshi Kikukawa, Eiji Sakuradani, Akinori Ando, Tomoyo Okuda, Sakayu Shimizu and Jun Ogawa : Microbial production of dihomo-γ-linolenic acid by Δ5-desaturase gene-disruptants of Mortierella alpina 1S-4., Journal of Bioscience and Bioengineering, Vol.122, No.1, pp.22-26, 2016.

【総説・解説】

1. 松木 均, 後藤 優樹 : 高圧力による脂質の相転移制御, 冷凍, Vol.88, No.1026, 274-279頁, 2013年4月.

2. 後藤 優樹 : 高圧蛍光法によるホスファチジルコリン二重膜のイメージング, 高圧力の科学と技術, Vol.23, No.1, 157-166頁, 2013年5月.

3. Eiji Sakuradani, Akinori Ando, Sakayu Shimizu and Jun Ogawa : Metabolic engineering for the production of polyunsaturated fatty acids by oleaginous fungus Mortierella alpina 1S-4, Journal of Bioscience and Bioengineering, Vol.116, No.4, pp.417-422, Oct. 2013.

4. 髙橋 章, 粟飯原 睦美, 馬渡 一諭, 芥川 正武 : 近紫外線発光ダイオードを用いた殺菌システム, 食品分野における非加熱殺菌技術, 150-166頁, 2013年11月.

5. 渡辺 崇人, 三戸 太郎, 野地 澄晴 : ZFN/TALENを用いたコオロギの遺伝子ノックアウト, 細胞工学, Vol.32, No.5, 543-549頁, 2013年(99月).

6. 松木 均, 後藤 優樹, 玉井 伸岳 : 飽和ジアシルホスファチジルコリン二重膜の温度および圧力誘起相転移, 熱測定, Vol.41, No.2, 66-73頁, 2014年4月.

7. 玉井 伸岳, 後藤 優樹, 松木 均 : 脂質ラフトは熱力学的に説明できるのか?―非調和融点型固液相図とクラスター形成―, 生物物理, Vol.54, No.3, 154-157頁, 2014年5月.

8. 後藤 優樹 : ハロゲン化ジアルキルジメチルアンモニウム二重膜の会合挙動:高圧力研究による相状態の解明, C & I commun colloid & interface communication : newsletter from DCSC, Vol.1, No.40, 31-33頁, 2015年3月.

9. 玉井 伸岳, 後藤 優樹, 松木 均 : 圧力摂動熱量法によるリン脂質二分子膜の体積挙動および緩和挙動の定量的観測, 高圧力の科学と技術, Vol.25, No.2, 109-115頁, 2015年5月.

【国際会議 Proceedings】

1. Masaki Hashizume, Masatake Akutagawa, Shyue-Kung Lu and Hiroyuki Yotsuyanagi : Electrical Test Method of Open Defects at Bi-directional Interconnects in 3D ICs, Proceedings of ICEP2013, pp.13-18, Osaka, Japan, April 2013.

2. Masachika Ishizaki and Masatake Akutagawa : Represent UV-A sterilization by model equation, BioEM2013, (巻), (号), (頁), Thessaloniki, June 2013.

3. Teppei Hoshiyama, Masatake Akutagawa, Mutsumi Aihara, Mario Hayashida, Akira Takahashi, Takahiro Emoto, Shinsuke Konaka and Yohsuke Kinouchi : Gene expression analysis of Vibrio parahaemolyticus for UV irradiation, BioEM2013, (巻), (号), p.94, Thessaloniki, June 2013.

4. Yohei Sasaki, Masatake Akutagawa, Takahiro Emoto, Yoshinori Tegawa and Yohsuke Kinouchi : Theoretical study of evaluation method for MRI metal artifact, Proceedings of 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, (巻), (号), pp.1073-1076, Osaka, July 2013.

5. Takahito Watanabe, Ochiai Hiroshi, Sakuma Tetsushi, Ishihara Satoshi, Nakamura Taro, Yamamoto Takashi, Sumihare Noji and Taro Mito : Targeted genome modifications in the cricket, Gryllus bimaculatus, Conference of Transposition & Genome Engineering 2013, (巻), (号), (頁), Budapest, Hungary, Sep. 2013.

6. Eiji Sakuradani, Akinori Ando, Takaiku Sakamoto, Jun Shima, Sakayu Shimizu and Jun Ogawa : Microbial Production of Various Polyunsaturated Fatty Acids by Molecular Breeding of oleaginous fungus Mortierella alpina, The 1st International Symposium on Microbial Technology for Food and Energy Security, (巻), (号), (頁), Bangkok Thailand, Nov. 2013.

7. Hitoshi Matsuki, Masaki GOTO and Nobutake Tamai : Pressure-induced Bilayer Interdigitation: Model of Molecular-ordering Formation in Lipid Membranes, The 2nd International Symposium ``Dynamical ordering of biomolecular systems for creation of integrated functions'', Kyoto, Jan. 2014.

8. Takahito Watanabe, Matsuoka Yuji, Sumihare Noji and Taro Mito : Targeted genome editing in the cricket, Gryllus bimaculatus, using CRISPR/Cas9 system, FASEB SRC on Genome Engineering-Cutting-Edge Research and Applications, (巻), (号), (頁), Nassau, Bahamas, Jan. 2014.

9. Mutsumi Aihara, Takashi Uebansou, Takaaki Shimohata, Kazuaki Mawatari, Masatake Akutagawa, Yohsuke Kinouchi and Akira Takahashi : Simultaneous irradiation with different wavelengths of ultraviolet light has synergistic bactericidal effect on Vibrio parahaemolyticus, 48th US-Japan Cooperative Medical Sciences Program Conference on cholera and Other Bacterial Enteric Infections, (都市), Feb. 2014.

10. Taro Mito, Takahito Watanabe and Sumihare Noji : Genome modification technology in the cricket Gryllus bimaculatus, 1st Asian Invertebrate Immunity Symposium, (巻), (号), (頁), Busan, Feb. 2014.

11. Akihiro Yasue, Silvia Naomi MITSUI AKAGI, H Watanabe, T Sakuma, Seiichi Oyadomari, T Yamamoto, Sumihare Noji, Taro Mito and Eiji Tanaka : A high efficient gene targeting in one-cell mouse embryos mediated by TALEN and CRISPR/Cas system., International Symposium on RNAi and Genome Editing Methods, Tokushima, March 2014.

12. Taro Mito : RNAi analysis and genome sequencing in the cricket Gryllus bimaculatus, a model for evolutionary developmental studies, International Symposium on RNAi and Genome editing methods, (巻), (号), (頁), Tokushima, Japan, March 2014.

13. Takahito Watanabe, Sumihare Noji and Taro Mito : Targeted genome modifications in the cricket, Gryllus bimaculatus, using CRISPR/Cas9 system, International Symposium on RNAi and Genome editing methods, (巻), (号), (頁), Tokushima, Japan, March 2014.

14. Nakamura Taro, Sumihare Noji and Taro Mito : Molecular mechanisms underlying early embryonic patterning and germ cell specification in the cricket, International Symposium on RNAi and Genome editing methods, (巻), (号), (頁), Tokushima, Japan, March 2014.

15. A. Ando, T. Okuda, Eiji Sakuradani, J. Shima, J. Ogawa and S. Shimizu : Studies of Oleaginous Filamentous Fungus Mortierella alpina for Useful Polyunsaturated Fatty Acid Production, 105th American Oil Chemists' Society Annual Meeting & Expo., San Antonio, May 2014.

16. H. Kikukawa, Eiji Sakuradani, S. Kishino, S.B. Park, A. Ando, J. Shima, M. Ochiai, S. Shimizu and J. Ogawa : Characterization of a Trifunctional Fatty Acid Desaturase from Oleaginous Filamentous Fungus Mortierella alpina 1S-4 Using a Yeast Expression System, 105th American Oil Chemists' Society Annual Meeting & Expo., San Antonio, May 2014.

17. Sumihare Noji, Taro Mito, Bando Tetsuya, Nakamura Taro, Takahito Watanabe, Ishimaru Yoshiyasu and Hideyo Ohuchi : Regeneration of insect legs from stem cells, Thirteenth International Congress on Invertebrate Reproduction and Development, Detroit, (巻), (号), (頁), Detroit, MI, USA, July 2014.

18. Takahiro Yano, Masaki GOTO, Nobutake Tamai and Hitoshi Matsuki : Barotropic Phase Behavior of Asymmetric Phosphatidylcholine Bilayers, 8th International Conference on High Pressure Bioscience and Biotechnology (HPBB2014), Nantes, France, July 2014.

19. Hitoshi Matsuki, Masaki GOTO and Nobutake Tamai : Barotropic Structural Change of Lipid Membranes: Characteristics and Mechanism of Bilayer Interdigitation, 8th International Conference on High Pressure Bioscience and Biotechnology (HPBB2014), Nantes, France, July 2014.

20. Takahiro Yano, Yoshioka Tatsuro, Nobutake Tamai, Masaki GOTO, Hitoshi Matsuki, Nagasawa Makoto and Matsumoto Masamitsu : Precise Measuring System of Density for Liquids under High Pressure, 8th International Conference on High Pressure Bioscience and Biotechnology (HPBB2014), Nantes, France, July 2014.

21. Taro Mito : Whole-genome sequencing and targeted genome editing in the cricket G. bimaculatus, Hokkaido Neuroethology Workshops 2014, (巻), (号), (頁), 札幌, July 2014.

22. Toshikazu Irie, Takashi Suetomi, Takaiku Sakamoto, Yoshitaka Tokunaga, Yoichi Honda, Hisatoshi Kamitsuji, Isamu Kameshita, Kousuk Izumitsu and Kazumi Suzuki : Effects of CaM on manganese peroxidase expression in Pleurotus ostreatus., The 10th International Mycological Congress, (巻), (号), (頁), Bangkok Thailand, Aug. 2014.

23. Teruaki Ito, Eiichi Honda, Tetsuo Ichikawa, Yohsuke Kinouchi, Masatake Akutagawa, Takahiro Emoto and Midori Yoshida : 1/F noise-fluctuated cozy lighting system for concentration improvement, Proceedings of the ASME 2014 International Design Engineering Technical Conferences & Computers and Information in Engineering Conference, No.34335, pp.1-10, Buffalo, Aug. 2014.

24. J. Ogawa, Eiji Sakuradani, S. Kishino, A. Ando and S. Shimizu : Fermentative production of polyunsaturated fatty acids and their unique transformation by gut microorganisms, 1st Asian Conference on Oleo Science, Sapporo, Sep. 2014.

25. Akihiro Yasue, Silvia Naomi MITSUI AKAGI, Teppei Watanabe, T Sakuma, Seiichi Oyadomari, T Yamamoto, Sumihare Noji, Taro Mito and Eiji Tanaka : Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by TALEN and CRISPR/Cas systems, X meeting for Spanish Society for Developmental Biology (SEBD), (頁), Madrid, Oct. 2014.

26. Akinori Ando, Tomoyo Okuda, Hiroshi Kikukawa, Eiji Sakuradani, Jun Shima, Jun Ogawa and Sakayu Shimizu : Various Rare Polyunsaturated Fatty Acid Productions by Mortierella alpina Breeding., 106th AOCS Annual Meeting & Expo, (巻), (号), (頁), Utah, May 2015.

27. Hiroshi Kikukawa, Eiji Sakuradani, Akinori Ando, Sakayu Shimizu and Jun Ogawa : The effect of hydroxy and oxo fatty acids generated by Lactobacillus plantarum on oxidative stress., 106th AOCS Annual Meeting & Expo, (巻), (号), (頁), Utah USA, May 2015.

28. Taro Mito, Itoh Takehiko, Morimoto Hiroya, Kajitani Ray, Toyoda Atsushi, Sayuri Tomonari, Fuketa Masao, Takahito Watanabe, Matsuoka Yuji and Sumihare Noji : Genome sequencing and annotation of the cricket Gryllus bimaculatus, a hemimetabolous insect model, Ninth Annual Arthropod Genomics Symposium, Manhattan, Kansas, USA, June 2015.

29. Takahito Watanabe, Matsuoka Yuji, Sayuri Tomonari, Kurita Chinami, Sumihare Noji and Taro Mito : Genome editing in the two-spotted cricket, Gryllus bimaculatus, using CRISPR/Cas9 system, Insect Genetic Technologies Workshop, Manhattan, Kansas, USA, June 2015.

30. Tsunedomi Akari, Masamura Akinori, Mutsumi Nakahashi, Nishisaka Risa, Kazuaki Mawatari, Takaaki Shimohata, Takashi Uebansou, Katsuyuki Miyawaki, Masatake Akutagawa, Yohsuke Kinouchi and Akira Takahashi : Disinfection system with UVA-LED for hydroponic nutrient solution, 6th FEMS Microbiology Congress, (都市), June 2015.

31. Tadahiko Nakagawa, Yoshifumi Takaoka, Hironori Tanaka, Kumiko Tanaka, Tetsuji Takayama, Takaaki Shimohata, Takashi Uebansou, Kazuaki Mawatari, Akira Takahashi, Masatake Akutagawa, Takahiro Emoto, Yohsuke Kinouchi, Toru Murashima, Satoru Yamaji, Zenji Tanaka, Masahiro Sogabe and Toshiya Okahisa : Roller Pump Circulation System For Preventing Filter Clogging During Cell-free and Concentrated Ascites Reinfusion Therapy (cart)., The 61th Annual Conference of American Society for Artificial Internal Organs(ASAIO), Chicago, June 2015.

32. Matsuoka Yuji, Takahito Watanabe, Sayuri Tomonari, Sumihare Noji and Taro Mito : Functional analysis of a Hox gene, abdominal-A, using CRISPR/Cas9 system in the cricket Gryllus bimaculatus, International Tribolium Meeting 2015, Berkeley, USA, Aug. 2015.

33. Mazenan Nizam Mohd, Tan Swee Tian, Soh Samson Sarah, Azmi Azhim Noor Azran, Hirofumi Nagashino, Masatake Akutagawa, Takahiro Emoto, Izamshah Raja, Kasim Shahir Mohd and Teruaki Ito : Malay Corpus Design for Articulation Disorder Patient for Early Screening Diagnosis, Proceedings of International Design and Concurrent Engineering Conference 2015 (iDECON2015), (巻), No.51, pp.1-11, Tokushima, Sep. 2015.

34. Hiroshi Kikukawa, Eiji Sakuradani, Shigenobu Kishino, Si-Bum Park, Akinori Ando, Sakayu Shimizu and Jun Ogawa : Characterization of a trifunctional ω3-desaturase from oleaginous fungus Mortierella alpina 1S-4 using a yeast expression system., 18th Japanese-German Workshop Enzyme Technology, (巻), (号), (頁), Kyoto, Sep. 2015.

35. Eiji Kondo, Masatake Akutagawa, Takahiro Emoto, Yoshio Kaji, Fumio Shichijo, Kazuhiko Furukawa, Hirofumi Nagashino, Shinsuke Konaka and Yohsuke Kinouchi : Syncronization analysis of EEG using the Hilbert Huang Coherence, International Conference on Biomedical and Health Informatics (ICBHI 2015), p.19, Haikou, Oct. 2015.

36. Takeshi Shono, Takahiro Emoto, Udantha R. Abeyratne, Masatake Akutagawa and Yohsuke Kinouchi : A HUMAN ABSOLUTE PITCH MODEL FOR IDENTIFYING MUSICAL PITCH, Proceedings of the 12th IASTED International Conference on biomedical engineering(biomed 2016), (巻), (号), pp.60-63, Austria, Feb. 2016.

37. Takahiro Emoto, Udantha R. Abeyratne, Takeshi Shono, Ryo Nonaka, Osamu Jinnouchi, Ikuji Kawata, Masatake Akutagawa and Yohsuke Kinouchi : AUDITORY IMAGE MODEL FOR THE CHARACTERISATION OF OBSTRUCTIVE SLEEP APNOEA, Proceedings of the 12th IASTED International Conference on biomedical engineering(biomed 2016), (巻), (号), pp.145-148, Austria, Feb. 2016.

【特許・実用新案】

1. 入江 俊一, 矢尾 祐樹, 阪本 鷹行, 鈴木 一実 : 真正担子菌のラッカーゼ産生能を増加させる方法, 特願2012-265662 (2012年12月), 特開2014-108103 (2014年6月), (番号) ((年月日)).